Silicon-Based Optical Biosensors

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Optical Chemical Sensors".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2149

Special Issue Editors


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Guest Editor
Scuola Superiore Sant'Anna di Studi Universitari e di Perfezionamento, Pisa, Italy
Interests: silicon photonics; biophotonics; integrated optics; chemical sensors; optical fiber sensors
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 110, Taiwan
Interests: nanomedicine; biomedical applications; antibacterial nanomaterials; nanoclusters; sensing; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This special issue covers all topics in the field of silicon-based optical biosensors, a Special Issue for the Journal Chemosensors. Chemosensors is an international, scientific, peer-reviewed, open access journal on the science and technology of chemical sensors published quarterly online by MDPI.

A chemosensor is a molecular system for which the physiochemical properties change upon interaction with a chemical species in such a way as to produce a detectable signal. The goal of this Special Issue is to cover the latest advancements on silicon-based optical biosensors, which are a special kind of chemosensor that has received a lot of attention in the last decade.

Biosensors can foster the mature technology available in silicon-based platforms, and they can offer the possibility to propose a large variety of sensing components that could be produced in large scales at a very low cost, which opens many potential applications, for example: point-of-care in healthcare, environmental monitoring, safety monitoring, or even food industry.

In particular, the field of integrated optics based on silicon platforms is expected to be of crucial importance for the development of biosensing applications. In this Special Issue, we expect to receive original contributions on a series of topics around this theme, as listed below.

All types of studies are allowed, both theoretical and experimental. Design and characterization techniques that could be applied in the field of biosensing are welcome as well as reviews on a specific topic listed below.

Topics include (but are not limited to):

  • Silicon photonics based biosensing;
  • Silicon-compatible platforms for biosensing, such as silicon nitride or glass;
  • Photonic techniques for biosensing;
  • Photonic sensing and measurement;
  • Biophotonics at large, based on silicon-compatible platforms; and
  • Innovative applications of biosensing (spectroscopy, genomics, etc.).

On behalf of the Guest Editors and the Editor‐in‐Chief, we encourage you to submit your work for inclusion in this Special Issue. There is no page limit for the contributions. Therefore, if you have struggled to find a place to publish a comprehensive study with detailed results, Chemosensors is the perfect place for it.

Dr. Philippe Velha
Dr. Tsung-Rong Kuo
Guest Editor

If you want to learn more information or need any advice, you can contact the Special Issue Editor Tammy Zhang via <[email protected]> directly.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biophotonics
  • integrated optics
  • silicon photonics
  • silicon-compatible sensors
  • biosensors
  • optical biosensors
  • chemical sensors
  • sensor design and characterization

Published Papers (1 paper)

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Research

11 pages, 1572 KiB  
Article
Botulinum Neurotoxin-C Detection Using Nanostructured Porous Silicon Interferometer
by Dashananda Nanda Kumar, Zina Baider, Daniel Elad, Shlomo E. Blum and Giorgi Shtenberg
Chemosensors 2021, 9(8), 228; https://0-doi-org.brum.beds.ac.uk/10.3390/chemosensors9080228 - 16 Aug 2021
Cited by 3 | Viewed by 1721
Abstract
Botulinum neurotoxins (BoNT) are the most potent toxins, which are produced by Clostridium bacteria and cause the life-threatening disease of botulism in all vertebrates. Specifically, animal botulism represents a serious environmental and economic concern in animal production due to the high mortality rates [...] Read more.
Botulinum neurotoxins (BoNT) are the most potent toxins, which are produced by Clostridium bacteria and cause the life-threatening disease of botulism in all vertebrates. Specifically, animal botulism represents a serious environmental and economic concern in animal production due to the high mortality rates observed during outbreaks. Despite the availability of vaccines against BoNT, there are still many outbreaks of botulism worldwide. Alternative assays capable of replacing the conventional in vivo assay in terms of rapid and sensitive quantification, and the applicability for on-site analysis, have long been perused. Herein, we present a simple, highly sensitive and label-free optical biosensor for real-time detection of BoNT serotype C using a porous silicon Fabry–Pérot interferometer. A competitive immunoassay coupled to a biochemical cascade reaction was adapted for optical signal amplification. The resulting insoluble precipitates accumulated within the nanostructure changed the reflectivity spectra by alternating the averaged refractive index. The augmented optical performance allowed for a linear response within the range of 10 to 10,000 pg mL−1 while presenting a detection limit of 4.8 pg mL−1. The practical aspect of the developed assay was verified using field BoNT holotoxins to exemplify the potential use of the developed optical approach for rapid bio-diagnosis of BoNT. The specificity and selectivity of the assay were successfully validated using an adjacent holotoxin relevant for farm animals (BoNT serotype D). Overall, this work sets the foundation for implementing a miniaturized interferometer for routine on-site botulism diagnosis, thus significantly reducing the need for animal experimentation and shortening analysis turnaround for early evidence-based therapy. Full article
(This article belongs to the Special Issue Silicon-Based Optical Biosensors)
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