Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.0
2.4
Journals
Children
Special Issues
Long-Term Effects of Maternal Diabetes and Obesity on the Offspring
share announcement

Long-Term Effects of Maternal Diabetes and Obesity on the Offspring

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3733

Special Issue Editors

Prof. Dr. Katarzyna Wroblewska-Seniuk

E-Mail Website
Guest Editor
Department of Newborns' Infectious Diseases, Poznan University of Medical Sciences, ul. Polna 33, 60-535 Poznan, Poland
Interests: newborns' infectious diseases; extrauterine growth restriction; newborns of diabetic mothers; neonatal hyperinsulinism and hypoglycemia
Prof. Agnieszka Zawiejska

E-Mail Website
Guest Editor
Department of Reproduction, Poznan University of Medical Sciences, 60-512 Poznan, Poland
Interests: Gestational diabetes; newborns of diabetic mothers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The incidence of gestational diabetes mellitus (GDM) and overt diabetes in pregnancy is rising globally. The newborns of diabetic mothers are at risk of a number of different complications, such as respiratory distress, perinatal injuries, hypoglycaemia, and electrolyte disturbances. Diabetes in pregnancy is also associated with negative long-term health outcomes for both mothers and offspring. The children tend to be overweight or obese, and they present with glucose intolerance or diabetes. Maternal overweight is an additional important factor that leads to such disturbances. There is some evidence suggesting that the association between maternal diabetes and obesity and adverse metabolic profile in offspring becomes more significant with increasing offspring age and that it is more pronounced in female offspring than in male offspring.

The goal of this Special Issue of Children is to provide an overview of recent advances in the field of the long-term effects of maternal diabetes and obesity on offspring. Therefore, researchers in the field of neonatology, paediatrics and maternal diabetes are encouraged to submit an original article or review to this Special Issue.

We look forward to receiving your contributions.

Prof. Katarzyna Wroblewska-Seniuk
Prof. Agnieszka Zawiejska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregestational diabetes mellitus
  • gestational diabetes mellitus
  • diabetes in pregnancy
  • long-term consequences
  • overweight
  • obesity
  • glucose intolerance
  • children

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

14 pages, 671 KiB  
Review
Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring
by Megan Beetch and Emilyn U. Alejandro
Children 2021, 8(11), 970; https://0-doi-org.brum.beds.ac.uk/10.3390/children8110970 - 26 Oct 2021
Cited by 5 | Viewed by 2915
Abstract
Robust evidence of fetal programming of adult disease has surfaced in the last several decades. Human and preclinical investigations of intrauterine insults report perturbations in placental nutrient sensing by the mechanistic target of rapamycin (mTOR). This review focuses on pregnancy complications associated with [...] Read more.
Robust evidence of fetal programming of adult disease has surfaced in the last several decades. Human and preclinical investigations of intrauterine insults report perturbations in placental nutrient sensing by the mechanistic target of rapamycin (mTOR). This review focuses on pregnancy complications associated with placental mTOR regulation, such as fetal growth restriction (FGR), fetal overgrowth, gestational diabetes mellitus (GDM), polycystic ovarian syndrome (PCOS), maternal nutrient restriction (MNR), preeclampsia (PE), maternal smoking, and related effects on offspring birthweight. The link between mTOR-associated birthweight outcomes and offspring metabolic health trajectory with a focus on sexual dimorphism are discussed. Both human physiology and animal models are summarized to facilitate in depth understanding. GDM, PCOS and fetal overgrowth are associated with increased placental mTOR, whereas FGR, MNR and maternal smoking are linked to decreased placental mTOR activity. Generally, birth weight is reduced in complications with decreased mTOR (i.e., FGR, MNR, maternal smoking) and higher with increased mTOR (GDM, PCOS). Offspring display obesity or a higher body mass index in childhood and adulthood, impaired glucose and insulin tolerance in adulthood, and deficiencies in pancreatic beta-cell mass and function compared to offspring from uncomplicated pregnancies. Defining causal players in the fetal programming of offspring metabolic health across the lifespan will aid in stopping the vicious cycle of obesity and type II diabetes. Full article
(This article belongs to the Special Issue Long-Term Effects of Maternal Diabetes and Obesity on the Offspring)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop