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Special Issue "Bioactive Compounds on Mental Disorders"

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Sungho Maeng
E-Mail Website
Guest Editor
Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Korea
Interests: depression; stress; resilience; post-traumatic stress disorder; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mental disorders are the leading cause of disability which continues to grow with significant impacts on health and major social, human rights and economic consequences in all countries of the world. Personal and social factors are attributable to mental health in combination with stress, nutrition, infection, and genetic factors. Studies have revealed many divergent biological systems that are implicated in the pathophysiology of mental disorders and provided numerous pharmacological targets. Many central nervous system acting drugs have been developed and are in use for treatment.

Nevertheless, the exact pathogenesis of most mental disorders is not known, and therapeutic reagents have many problems, such as suboptimal effect, high recurrence, multiple side effects, and requiring long-term administration. Accordingly, there is a need of novel drugs with improved effects.

This Special Issue “Bioactive Compounds on Mental Disorders” aims to gather contributions from basic scientists and clinical researchers to examine the issue of novel bioactive molecules with therapeutic effects on mental disorders. 

This special issue has a Joint Special Issue with IJMS (IF 5.923).

Notes: The focus of this issue is describing the mechanism of bioactive molecules in improving mental disorders. We welcome submissions and studies on nutritional applications using biological, chemical, cellular, molecular, and immunological methods.

Prof. Dr. Sungho Maeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • schizophrenia
  • stress disorders
  • depression
  • bipolar disorder
  • anxiety
  • autism
  • dementia
  • mental health

Published Papers (1 paper)

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Research

Article
Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause
Curr. Issues Mol. Biol. 2021, 43(3), 1669-1684; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb43030118 - 19 Oct 2021
Viewed by 386
Abstract
Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransferase and brain-derived neurotrophic factor; thus, [...] Read more.
Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransferase and brain-derived neurotrophic factor; thus, postmenopausal women experience cognitive decline and more depressive symptoms than age-matched men. Radix Polygalae has been used for memory boosting and as a mood stabilizer and its components have shown neuroprotective, antidepressant, and stress relief properties. In a mouse model of estrogen depletion induced by 4-vinylcyclohexene diepoxide, Radix Polygalae was orally administered for 3 weeks. In these animals, cognitive and depression-related behaviors and molecular changes related to these behaviors were measured in the prefrontal cortex and hippocampus. Radix Polygalae improved working memory and contextual memory and despair-related behaviors in 4-vinylcyclohexene diepoxide-treated mice without increasing serum estradiol levels in this model. In relation to these behaviors, choline acetyltransferase and brain-derived neurotrophic factor in the prefrontal cortex and hippocampus and bcl-2-associated athanogene expression increased in the hippocampus. These results implicate the possible benefit of Radix Polygalae in use as a supplement of estrogen to prevent conditions such as postmenopausal depression and cognitive decline. Full article
(This article belongs to the Special Issue Bioactive Compounds on Mental Disorders)
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