Dear Colleagues,

Obstructive sleep apnea syndrome (OSAS) is a frequent condition estimated to affect 5%–12% of the adult population, and its impact on cardiovascular risk seems to be consistent.

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are sympathetic activity, oxidative stress, and inflammation. Other affected domains include adipokines, adhesion molecules, and molecules that respond to endoplasmic reticulum stress.

During the last decade, significant steps towards a precision medicine approach have been taken, including in the field of sleep disorder management.

The aim of this Special Issue is to collect molecular approaches in diagnostic advancements and targeted therapy outcomes of OSAS and other sleep disorders.

In particular, we will consider papers regarding:

Novel aspects of CPAP treatment and interventions to improve CPAP adherence;

Emerging the pharmacotherapy of OSA;

Evaluation of OSA-related biomarkers;

Pathogenetic mechanisms and consequences of OSA;

Chronic intermittent hypoxia;

Sleep fragmentation;

Innovative therapies for OSA treatment.

We are certain that your active collaboration would help to create an interesting Special Issue that will aid physicians in identifying the most appropriate therapeutic choice for patients affected by sleep disorders.

Prof. Claudio Vicini
Dr. Giovanni Cammaroto
Guest Editors

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• sleep disorders
• obstructive sleep apnea
• sleepiness health
• CPAP
• quality of life
• prevention