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Biomedical Application of Natural Plant Extracts
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Biomedical Application of Natural Plant Extracts

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (31 December 2021)

Special Issue Editor

Prof. Dr. El-Sayed Abd El-Aziz

E-Mail Website
Guest Editor
Department of Pharmacology, Pharmacology, Zagazig University, 44519 Zagazig, Egypt
Interests: cancer biology; natural plant activities; oxidative stress; molecular biology; diabetes mellitus; hepatoprotective; testicular protection; metal drug complexes; plant extracts; MTT assay; cell line experiments; wound-healing cellular assay; cell migration assay; renal functions; hepatorenal functions; chemical characterizations; chitosan; flavonoid activities; phenolic activities; zinc oxide nanoparticle activities; COVID-19; antibacterial activities; antiviral activities; DPPH activity; natural extracts; HPLC; UHPLC-UV; FTIR; spectroscopic analysis; zeta potential; surface area; flow cytometry; quantitative assay; qualitative assay; cytotoxicity assay; apoptosis; natural residues; solid waste; industrial waste; aging; neuroprotective agents; active compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent experimental developments in nanoformulations with different biomedical activity based on natural plant extracts and the efficacy of the active compounds within them are among the most highly exploited research systems in the field of biological sciences. Driven by the current state of knowledge on the biomedical efficiency of plant extracts, the need to maintain structural material integrity and reliability under harsh environments, and a renewed impetus towards durability of new nanostructured coating systems, have seen a huge demand on experimental, theoretical, and modelling activities.

Extensive study has been made of the hepatoprotective, neuroprotective, and testicular protective activities of natural plant extracts and many active compounds against different disorders and aging progression, and studies have yielded great benefits from these compounds thanks to complete chemical characterization and spectroscopic analysis. Beside testing the wound healing assay of some compounds and testing the activities of antibiotic metal drug complexes and flavonoid metal drug complexes against environmental infections.

This scope of this Special Issue will serve as a forum for papers on the following topics:

  • Experimental research, knowledge and new ideas about the protective effects of natural plant extracts against different diseases.
  • Recent developments in the quantitative and qualitative activities of natural products and active compounds.
  • Anti-cancer activities of some natural plant extracts and nanoformulations.
  • High-performance chromatography experimentation and processing with exposure to high temperatures, high stress, and other extreme environmental conditions.
  • Understanding the chemical characterization of different nanoparticle coatings and their biological activities.
  • The latest developments in anti-diabetic agents from natural plant extracts and different chemical agents.
  • Computer modeling and simulation to predict nanoparticle coating properties and performance in service environments.
  • Metal drug and natural extract complexes with antibiotics and flavonoids with chemical characterization and spectroscopic analysis against infections.

Prof. El-Sayed Abd El-Aziz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical activities of natural plant extracts
  • nanoparticle activities
  • antibacterial and antiviral activities
  • protective effects of active compounds
  • wound healing assay

Published Papers (17 papers)

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15 pages, 9741 KiB  
Article
Anethum graveolens Prevents Liver and Kidney Injury, Oxidative Stress and Inflammation in Mice Exposed to Nicotine Perinatally
by Jamaan S. Ajarem, Saleh N. Maodaa, Hamed A. El-Serehy, Naif Altoom, Ahmed A. Allam, Rene Hernandez-Bautista and Ayman M. Mahmoud
Coatings 2021, 11(7), 838; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11070838 - 13 Jul 2021
Viewed by 2096
Abstract
Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated the effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury in the liver and kidney of mice newborns exposed to nicotine perinatally. Pregnant mice received nicotine (0.25 [...] Read more.
Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated the effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury in the liver and kidney of mice newborns exposed to nicotine perinatally. Pregnant mice received nicotine (0.25 mg/kg) on gestational day 12 to day 5 after birth and/or A. graveolens extract on gestational day 1 to day 15 after birth. Newborn mice exposed to nicotine showed multiple histopathological alterations in the kidney and liver, including inflammatory cell infiltration and degenerative changes. Nicotine exposure increased hepatic and renal reactive oxygen species (ROS), lipid peroxidation, tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) (p < 0.001), and decreased antioxidant defenses (p < 0.001). A. graveolens supplementation significantly prevented liver and kidney injury, suppressed ROS generation (p < 0.001), lipid peroxidation (p < 0.001) and inflammatory response (p < 0.001), and enhanced antioxidant defenses. In addition, A. graveolens upregulated hepatic and renal Nrf2 and HO-1 mRNA and increased HO-1 activity in normal and nicotine-exposed mice. In conclusion, A. graveolens protects against perinatal nicotine-induced oxidative stress, inflammation and tissue injury in the liver and kidney of newborn mice. A. graveolens upregulated hepatic and renal Nrf2/HO-1 signaling and enhanced antioxidant defenses in mice. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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11 pages, 1483 KiB  
Article
Safety of Commercially Available Beef Burger in Saudi Arabia
by Eman Hillal Al-Thubaiti, Abdulkader M. Shaikh Omar, Abdelfatteh El-Omri, Mohammed Al-Matary, Ali H. Al-Mwallad and Seham Mahmoud Eldeeb
Coatings 2021, 11(6), 686; https://doi.org/10.3390/coatings11060686 - 07 Jun 2021
Cited by 2 | Viewed by 3301 | Retraction
Abstract
The safety of meat has been at the forefront of societal concerns in recent years, and indications exist that challenges to meat safety will continue in the future. Major meat safety issues and related challenges include the need to control traditional and emerging [...] Read more.
The safety of meat has been at the forefront of societal concerns in recent years, and indications exist that challenges to meat safety will continue in the future. Major meat safety issues and related challenges include the need to control traditional and emerging pathogenic microorganisms, such as increased virulence and low infectious doses or resistance to antibiotics or food-related stresses. This study aimed to recognize microbial contamination and heavy metals content. Thirty-eight frozen and freshly prepared burger (local and imported) samples were collected from randomly selected supermarkets and fast-food restaurants in Jeddah. Yeasts/Molds had the highest count (204.3 CFU/mL) followed by total aerobic mesophiles (69.5 CFU/mL), total coliforms (16.2 CFU/mL) and Escherichia coli (10.0 CFU/mL). Salmonella species were positive in 39.5% of samples. Fresh burgers had more counts of TVC, total coliforms, Escherichia coli, and Bacillus cereus. Amoxicillin-clavulanate and Ampicillin had a high frequency of resistance in the studied sample. None of the studied samples had detectable traces of heavy metals’ elements. This research provides valid data to protect consumers from different health risks related to burgers in Saudi Arabia. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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16 pages, 7214 KiB  
Article
A New Sterilization Strategy Using TiO2 Nanotubes for Production of Free Radicals that Eliminate Viruses and Application of a Treatment Strategy to Combat Infections Caused by Emerging SARS-CoV-2 during the COVID-19 Pandemic
by Reham Z. Hamza, Adil A. Gobouri, Hatim M. Al-Yasi, Tarek A. Al-Talhi and Samy M. El-Megharbel
Coatings 2021, 11(6), 680; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11060680 - 04 Jun 2021
Cited by 29 | Viewed by 3591
Abstract
Synthesized titanium oxide nanoparticles (TiO2-NPs) nanotubes were used for the disinfection of new emerging corona virus-19 (SARS-CoV-2) in this study. The newly synthesized TiO2-NPs (nanotubes) were characterized by chemical spectroscopic analysis Fourier-transform infrared spectroscopy and ultraviolet FT-IR and UV. [...] Read more.
Synthesized titanium oxide nanoparticles (TiO2-NPs) nanotubes were used for the disinfection of new emerging corona virus-19 (SARS-CoV-2) in this study. The newly synthesized TiO2-NPs (nanotubes) were characterized by chemical spectroscopic analysis Fourier-transform infrared spectroscopy and ultraviolet FT-IR and UV. The chemical purity and Zeta potential distribution of the TiO2-NPs (nanotubes) were evaluated to confirm their nano-range, and their surface morphology was determined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and energy dispersive X-ray analysis (EDX). The antiviral activity of the TiO2-NPs (nanotubes) against SARS-CoV-2 was evaluated using 10% (Dimethyl sulfoxide) DMSO and dist.H2O using a cytotoxicity assay and inhibitory concentration assay (to determine the cytotoxic half concentration CC50 and half maximal inhibitory concentration IC50). The current results confirmed that TiO2-NPs exhibit strong anti-SARS-CoV-2 activity at very low cytotoxic concentrations in vitro with a non-significant selectivity index (CC50/IC50 ≤ 1). The obtained results indicate that TiO2-NPs and nanotubes have potent antiviral activity at a very low concentrations (IC50 = 568.6 ng/mL), with a weak cytotoxic effect on the cellular host (CC50 = 399.1 ng/mL). Thus, we highly recommend the use of TiO2-NPs (nanotubes) in vitro and in wall coatings as a potent disinfectant to combat SARS-CoV-2 with little irritation of the cellular hosts. Furthermore, we also recommend more and excessive prospective studies on the complexation of natural active or natural compounds with TiO2-NPs (nanotubes) to minimize their cytotoxicity, enhance their antiviral activity, and increase their inhibition of SARS-CoV-2. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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11 pages, 4662 KiB  
Article
Protective Effect of Resveratrol against Hepatotoxicity of Cadmium in Male Rats: Antioxidant and Histopathological Approaches
by Najah M. Al-Baqami and Reham Z. Hamza
Coatings 2021, 11(5), 594; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11050594 - 18 May 2021
Cited by 21 | Viewed by 3081
Abstract
Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It is a heavy metal with a number of side effects, including hepatotoxicity. Resveratrol (Rs) is considered an important polyphenol, which is a secondary plant metabolite and has the ability [...] Read more.
Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It is a heavy metal with a number of side effects, including hepatotoxicity. Resveratrol (Rs) is considered an important polyphenol, which is a secondary plant metabolite and has the ability to scavenge free radicals. The study was designed to evaluate the effects of resveratrol on Cd, which induced hepatotoxicity, by the assessment of some histopathological and biochemical alterations. Forty male albino rats were divided into four groups: the 1st group was the control group, the 2nd group was treated with Cd (5 mg/kg), the 3rd group was given Rs (20 mg/kg), and the 4th group was treated with Cd in combination with Rs intraperitoneally for 30 successive days. The results indicate that Cd increased liver enzymes alanine aminotransferase and aspartate aminotransferase (AST and ALT), alkaline phosphatase ALP and gamma-glutamyl transferase (γ-GT) while reducing the total protein level; Cd increased the malondialdhyde (MDA) level while decreasing the levels of other antioxidant enzymes super oxide dismutase, catalase and glutathione peroxidase (SOD, CAT and GPx). Serious congestion and hemorrhage related to the hepatic tissues were noticed in the Cd group, and Rs plays a major role in alleviating histopathological injuries and hepatic oxidative damage. It is clear that Rs has the ability to minimize the hepatotoxicity induced by Cd in male rats. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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14 pages, 5490 KiB  
Article
Antioxidant, Antigenotoxic, and Hepatic Ameliorative Effects of Quercetin/Zinc Complex on Cadmium-Induced Hepatotoxicity and Alterations in Hepatic Tissue Structure
by Moamen S. Refat, Reham Z. Hamza, Abdel Majid A. Adam, Hosam A. Saad, Adil A. Gobouri, Ehab Azab, Fawziah A. Al-Salmi, Tariq A. Altalhi, Ebtihal Khojah, Ahmed Gaber and Samy M. El-Megharbel
Coatings 2021, 11(5), 501; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11050501 - 24 Apr 2021
Cited by 18 | Viewed by 3472
Abstract
Applications of medicinal uses of metals and their complexes have been gaining major clinical significance, especially during the COVID-19 pandemic. The ligation behavior of quercetin (Q), a flavonoid, and Zn metal, i.e., the Zn/Q complex, was fully characterized based on molar conductance, infrared [...] Read more.
Applications of medicinal uses of metals and their complexes have been gaining major clinical significance, especially during the COVID-19 pandemic. The ligation behavior of quercetin (Q), a flavonoid, and Zn metal, i.e., the Zn/Q complex, was fully characterized based on molar conductance, infrared (IR) spectra, elemental analysis, electronic spectra, thermogravimetric analysis, proton nuclear magnetic resonance (1H-NMR), and transmission electron microscopy (TEM) in our lab. Hepatotoxicity was induced by cadmium (CdCl2). A total of 40 male albino rats were randomly distributed into the following four groups: Control, hepatotoxic group (CdCl2), Zn/Q-treated group, and group treated with a combination of CdCl2 and Zn/Q. Serum hepatic enzymes (AST, ALT, and LDH), total protein, and enzymatic and nonenzymatic antioxidant levels were determined. Histology and TEM for hepatic tissues, in addition to the gene expression of SOD as an antioxidant enzyme in the hepatic tissues, were evaluated. The Q/Zn treatment demonstrated potent protective effects against CdCl2-induced sever oxidative stress and suppressed hepatic toxicity, genotoxicity, liver enzyme disturbances, and structural alterations. In conclusion, the Zn/Q complex produced a high potent antioxidant effect against the oxidative injury and genotoxicity induced by CdCl2 and could be considered to be a potent ameliorative hepatoprotective agent against CdCl2 hepatotoxicity, which could be beneficial during the COVID-19 pandemic. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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19 pages, 6056 KiB  
Article
Neurological Alterations and Testicular Damages in Aging Induced by D-Galactose and Neuro and Testicular Protective Effects of Combinations of Chitosan Nanoparticles, Resveratrol and Quercetin in Male Mice
by Reham Z. Hamza, Mohammad S. Al-Harbi and Munirah A. Al-Hazaa
Coatings 2021, 11(4), 435; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11040435 - 09 Apr 2021
Cited by 7 | Viewed by 3155 | Retraction
Abstract
Aging is a neurological disease that is afforded by incidence of oxidative stress. Chitosan has received global interests due to its wide medical uses. Quercetin (Q) is a bioflavonoid and widely distributed in vegetables and fruits. Resveratrol is considered as a potent antioxidant [...] Read more.
Aging is a neurological disease that is afforded by incidence of oxidative stress. Chitosan has received global interests due to its wide medical uses. Quercetin (Q) is a bioflavonoid and widely distributed in vegetables and fruits. Resveratrol is considered as a potent antioxidant and is a component of a wide range of foods. The using of either chitosan nanopartciles (CH-NPs), querectin (Q), and resveratrol (RV) to reduce the oxidative stress and biochemical alterations on brain and testicular tissues induced by D-galactose (DG) (100 mg/Kg) were the aim of the present study. This study investigated the probable protective effects of CH-NPs in two doses (140,280 mg/Kg), Q (20 mg/Kg) and RV (20 mg/Kg), against DG induced aging and neurological alterations. Brain antioxidant capacity as malonaldehyde (MDA), catalase (CAT), and glutathione reductase (GRx), as well as histopathological damages of the brain and testicular tissues were measured. The DG treated group had significantly elevated the oxidative stress markers by 96% and 91.4% in brain and testicular tissues respectively and lower significantly the antioxidant enzyme activities of both brain and testicular tissues than those of the control group by 86.95%, 69.27%, 83.07%, and 69.43%. Groups of DG that treated with a combination of CH-NPs in two doses, Q and RV, the levels of oxidative stress marker declined significantly by 68.70%, 76.64% in brain tissues and by 74.07% and 76.61% in testicular tissues, and the enzymatic antioxidants increased significantly by 75.55%, 79.24%, 62.32%, and 61.97% as compared to the DG group. The present results indicate that CH-NPs, Q, and RV have protective effects against DG-induced brain and testis tissue damage at the biochemical and histopathological levels. Mechanisms of this protective effect of used compounds against neurological and testicular toxicity may be due to the enhanced brain and testis antioxidant capacities. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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12 pages, 1644 KiB  
Article
A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME
by Reham Z. Hamza, Abdel Aziz A. Diab, Mansour H. Zahra, Mai S. Attia, Suzan M. M. Moursi and Najah M. Al-Baqami
Coatings 2021, 11(4), 391; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11040391 - 30 Mar 2021
Cited by 5 | Viewed by 2094 | Retraction
Abstract
Background: Hypertensive disorders of pregnancy, gestational hypertension, and preeclampsia (PE) are exceptionally challenging, as their pathologies and therapeutic management simultaneously influence the mother and embryo, sometimes putting their well-beings at odds with each other. Dysregulated lipid and glucose metabolism may be related to [...] Read more.
Background: Hypertensive disorders of pregnancy, gestational hypertension, and preeclampsia (PE) are exceptionally challenging, as their pathologies and therapeutic management simultaneously influence the mother and embryo, sometimes putting their well-beings at odds with each other. Dysregulated lipid and glucose metabolism may be related to some cases of preeclampsia. Fluctuations in serum apelin levels may be attributed to changes in the serum levels of multiple interrelated factors such as insulin, insulin resistance, inflammatory cytokines, and nephritic damage. Previous studies demonstrated that apelin is an endogenous active peptide with vasodilatory and antioxidative-stress capabilities. Objective: We investigated the relationships among hepatic, nephrotic, and metabolic injuries in different preeclampsia-like mouse models and the potential effect of exogenous apelin administration on hepatic and nephrotic injuries and metabolic disorders in an N-nitro-L-arginine methyl ester (L-NAME) preeclampsia-like Sprague Dawley (SD) rat model. Materials and methods: Forty-three adult female and ten adult male SD rats were involved in this study. The male rats were used to induce pregnancy. The female rats were randomly divided into four equal groups: a non-pregnant group, a normal pregnant group, a group treated with L-NAME to induce preeclampsia, and a group treated with L-NAME and apelin. In all the groups, maternal blood was collected on the 21st day of gestation, and serum samples were used for the determination of systolic blood pressure; the serum uric acid, creatinine, nitric oxide (NO), xanthine oxidase, myeloperoxidase, insulin, glucose, cholesterol, triglyceride (TG), aspartate aminotransferase (AST) and alanine aspartate aminotransferase (ALT) levels; and the HOMA-insulin resistance (HOMA-IR). Results: In rats with pre-eclampsia, the systolic blood pressure; the concentrations of serum uric acid, creatinine, nitric oxide (NO), xanthine oxidase, myeloperoxidase, blood glucose, serum cholesterol, triglycerides, AST, and ALT; and the calculated HOMA-IR were significantly increased compared to those in the rats in the other groups. Additionally, apelin treatment significantly improved these parameters in the apelin-treated group. Conclusion: This study examined the potential mechanisms whereby apelin may act as a curative candidate to reduce hepatic injury and inhibit kidney damage and the development of metabolic disorders in an experimental model of preeclampsia. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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14 pages, 5657 KiB  
Article
Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—”ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)”
by Samy M. El-Megharbel, Mohammed Alsawat, Fawziah A. Al-Salmi and Reham Z. Hamza
Coatings 2021, 11(4), 388; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11040388 - 29 Mar 2021
Cited by 84 | Viewed by 8156 | Retraction
Abstract
A newly synthesized zinc (II) oxide nanoparticle (ZnO-NPs) has been used as a disinfectant Nano-spray for the emerging corona virus (SARS-CoV-2). The synthesized obtained nanomaterial of (ZnO) was fully chemically characterized by using different spectroscopic analysis (FT-IR, UV and XRD) and surface analysis [...] Read more.
A newly synthesized zinc (II) oxide nanoparticle (ZnO-NPs) has been used as a disinfectant Nano-spray for the emerging corona virus (SARS-CoV-2). The synthesized obtained nanomaterial of (ZnO) was fully chemically characterized by using different spectroscopic analysis (FT-IR, UV and XRD) and surface analysis techniques. ZnO-Nps surface morphology and chemical purity has been investigated by transmission electron microscope (TEM), high resolution transmission electron microscope (HR-TEM), scanning electron microscopy (SEM) as well as energy dispersive X-ray analysis (EDX), Additionally Zeta potential and Zeta size distribution were measured and evaluated to confirm its nano-range scale. The synthesized Zno-NPs have been tested using 10% DMSO and ddH2O for estimation of antiviral activity against (SARS-CoV-2) by using cytotoxicity assay (CC50) and inhibitory concentration (IC50). The results revealed that (Zno-NPs) has high anti-SARS-CoV-2 activity at cytotoxic concentrations in vitro with non-significant selectivity index (CC50/IC50 ≤ 1). The current study results demonstrated the (ZnO-NPs) has potent antiviral activity at low concentration (IC50 = 526 ng/mL) but with some cytotoxic effect to the cell host by (CC50 = 292.2 ng/mL). We recommend using of (ZnO-NPs) as potent disinfectant against (SARS-Cov-2), but there are slight side effects on the cellular host, so we recommend more prospective studies on complexation of other compounds with (ZnO-NPs) in different concentrations to reduce its cellular toxicity and elevate its antiviral activity against SARS-CoV-2 activities. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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18 pages, 5288 KiB  
Article
Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model
by Reham Z. Hamza, Shaden E. Al-Motaani and Tarek Al-Talhi
Coatings 2021, 11(3), 324; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11030324 - 11 Mar 2021
Cited by 9 | Viewed by 2664 | Retraction
Abstract
Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in [...] Read more.
Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals’ tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle’s promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant’s medical capabilities. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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16 pages, 2557 KiB  
Article
Efficacy of Mesenchymal Stem Cell and Vitamin D in the Treatment of Diabetes Mellitus Induced in a Rat Model: Pancreatic Tissues
by Reham Z. Hamza, Rasha A. Al-Eisa and Nahla S. El-Shenawy
Coatings 2021, 11(3), 317; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11030317 - 10 Mar 2021
Cited by 7 | Viewed by 3388 | Retraction
Abstract
Treatment with mesenchyme stem cells (MSCs) plays a significant role in the therapies of many diseases such as diabetics. Vitamin D plays a significant role in the development of insulin and can increase the insulin action sensitivity of peripheral tissues. Moreover, there is [...] Read more.
Treatment with mesenchyme stem cells (MSCs) plays a significant role in the therapies of many diseases such as diabetics. Vitamin D plays a significant role in the development of insulin and can increase the insulin action sensitivity of peripheral tissues. Moreover, there is limited research concerning the mechanism of the therapeutic action of MSCs with the combination of vitamin D (vit. D). Therefore, we evaluated the effect of MSC intervention in a diabetic animal model. Diabetes was induced by streptozotocin (STZ) injection at a dose of 50 mg/kg in adult male rats The diabetic rats were injected with MSCs derived from bone marrow (2 × 106 per rat), either alone or in combination with vit. D through the tail vein for four weeks. Serum insulin, glucose, C-peptide, glycosylated hemoglobin, and lipid profile levels were determined. Pancreatic oxidative stress, histology, and electron microscopy were evaluated, and the gene expression of cytokines was assessed by real-time polymerase chain reaction PCR. MSC treatment suppressed pancreatic inflammatory cytokine secretion and oxidative stress in diabetic rats, resulting in improved pancreatic histology and cellular structure, and the complication of hyperglycemia was observed. Engrafted MSCs were found inside degraded pancreatic regions and regulated inflammatory cytokines. Our results demonstrated that treatment with MSCs and vit. D in combination prevented pancreatic injury via antioxidant and immune regulation in diabetic rats, contributing to the prevention of pancreatic dysfunction, improvement of lipid metabolism, and regulation of cytokine gene expression compared with each one separately. All these mechanisms also improved the histological structure of the pancreas based on transmission electron microscopy. The combination of MSCs and vit. D appears to have contributed to a greater improvement in the diabetic pancreatic complication of rats than was observed by each one separately. Therefore, this association can be used as antidiabetic therapy. Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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1 pages, 134 KiB  
Expression of Concern
Expression of Concern: Hamza et al. A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME. Coatings 2021, 11, 391
by Coatings Editorial Office
Coatings 2021, 11(9), 1117; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091117 - 15 Sep 2021
Viewed by 1272
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 138 KiB  
Expression of Concern
Expression of Concern: Hamza et al. Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model. Coatings 2021, 11, 324
by Coatings Editorial Office
Coatings 2021, 11(9), 1116; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091116 - 15 Sep 2021
Cited by 6 | Viewed by 1620
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 133 KiB  
Expression of Concern
Expression of Concern: Al-Thubaiti et al. Safety of Commercially Available Beef Burger in Saudi Arabia. Coatings 2021, 11, 686
by Coatings Editorial Office
Coatings 2021, 11(9), 1115; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091115 - 15 Sep 2021
Viewed by 1110
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 137 KiB  
Expression of Concern
Expression of Concern: El-Megharbel et al. Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—“ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)”. Coatings 2021, 11, 388
by Coatings Editorial Office
Coatings 2021, 11(9), 1114; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091114 - 15 Sep 2021
Viewed by 1706
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 135 KiB  
Expression of Concern
Expression of Concern: Al-Baqami, N.M.; Hamza, R.Z. Protective Effect of Resveratrol against Hepatotoxicity of Cadmium in Male Rats: Antioxidant and Histopathological Approaches. Coatings 2021, 11, 594
by Coatings Editorial Office
Coatings 2021, 11(9), 1113; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091113 - 15 Sep 2021
Cited by 1 | Viewed by 1113
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 134 KiB  
Expression of Concern
Expression of Concern: Refat et al. Antioxidant, Antigenotoxic, and Hepatic Ameliorative Effects of Quercetin/Zinc Complex on Cadmium-Induced Hepatotoxicity and Alterations in Hepatic Tissue Structure. Coatings 2021, 11, 501
by Coatings Editorial Office
Coatings 2021, 11(9), 1112; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091112 - 15 Sep 2021
Cited by 1 | Viewed by 1585
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
1 pages, 135 KiB  
Expression of Concern
Expression of Concern: Hamza et al. Efficacy of Mesenchymal Stem Cell and Vitamin D in the Treatment of Diabetes Mellitus Induced in a Rat Model: Pancreatic Tissues. Coatings 2021, 11, 317
by Coatings Editorial Office
Coatings 2021, 11(9), 1111; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11091111 - 14 Sep 2021
Viewed by 1024
Abstract
Following acceptance of the Special Issue article by the Guest Editor, El-Sayed Abd El-Aziz, concerns were raised regarding the integrity of the peer review process [...] Full article
(This article belongs to the Special Issue Biomedical Application of Natural Plant Extracts)
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