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Novel Approaches to Combat Biofilms Formed on Medical Devices

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A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 14288

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Special Issue Editors

Dr. Luminiţa Məruţescu

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Guest Editor

1. Research Institute of the University of Bucharest (ICUB) Life, Environmental and Earth Sciences, Bucharest, Romania;
2. University of Bucharest, Faculty of Biology, Department of Microbiology and Botany, Bucharest, Romania
Interests: antimicrobial agents; microbial biofilms; flow cytometry

Dr. Graţiela Grădişteanu

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Guest Editor

1. Research Institute of the University of Bucharest (ICUB) Life, Environmental and Earth Sciences, Bucharest, Romania
2. Faculty of Biology, Department of Microbiology and Botany, University of Bucharest, Bucharest, Romania
Interests: microbial biofilms; host–pathogen interaction; microbiota
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Special Issue Information

Dear Colleagues,

We would like to invite you to submit your work to this Special Issue on “Novel Approaches to Combat Biofilms Formed on Medical Devices”. Biofilms comprise surface-attached microbial cells adherent to each other, embedded in a self-produced extracellular polymeric substance. Importantly, biofilms protect pathogens from adverse environmental conditions, are highly tolerant to antimicrobial agents, and represent important reservoirs and sources of 60%–80% of human infections, particularly in patients with implanted medical devices. Currently, the effective control of biofilm-associated infections using long-term antimicrobial therapy represents a major challenge due to the dramatic rise of antibiotic resistance. Consequently, there is an urgent need for novel approaches to overcome initial microbial attachment and subsequent biofilm formation on implantable medical devices. Several strategies are currently being investigated: coating the implant material with antimicrobial agents, changing the biomaterial surface to produce anti-adherent surfaces, and development of biofilm-disrupting agents (chemical or physical).

The aim of this Special Issue is to present the latest experimental and theoretical advances in the field, through a combination of original research papers and review articles from leading research groups around the world.

In particular, the topics of interest include but are not limited to:

Development of innovative therapeutic tools based on novel antibiofilm agents;
Strategies to overcome the bacterial colonization on implantable devices;
Nanomaterial-based antibiofilm strategies—from bench to bedside;
Updates on biofilm associated infections—etiology, virulence factors, resistance markers.

Dr. Luminiţa Məruţescu
Dr. Graţiela Grădişteanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

medical devices
biofilm-associated infections
nanomaterial-based antibiofilm strategies
antibiofilm coatings
anti-adherent surfaces
biofilm-disrupting agents

Published Papers (3 papers)

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Research

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16 pages, 2768 KiB

Open AccessArticle

Polydopamine-Assisted Surface Modification of Ti-6Al-4V Alloy with Anti-Biofilm Activity for Dental Implantology Applications

by Ioana Cristina Marinas, Bianca Maria Tihauan, Andreea Gabriela Diaconu, Xenia Filip, Anca Petran, Ioana-Georgeta Grosu, Diana Bogdan, Lucian Barbu, Ana Maria Ivanof, Marin Angheloiu, Grațiela Gradisteanu Pircalabioru and Claudiu Filip

Coatings 2021, 11(11), 1385; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11111385 - 12 Nov 2021

Cited by 4 | Viewed by 1821

Abstract

Coating the surfaces of implantable materials with various active principles to ensure inhibition of microbial adhesion, is a solution to reduce infections associated with dental implant. The aim of the study was to optimize the polydopamine films coating on the Ti-6Al-6V alloy surface in order to obtain a maximum of antimicrobial/antibiofilm efficacy and reduced cytotoxicity. Surface characterization was performed by evaluating the morphology (SEM, AFM) and structures (Solid-state 13C NMR and EPR). Antimicrobial activity was assessed by logarithmic reduction of CFU/mL, and the antibiofilm activity by reducing the adhesion of Escherichia coli, Staphylococcus aureus, and Candida albicans strains. The release of NO was observed especially for C. albicans strain, which confirms the results obtained for microbial adhesion. Among the PDA coatings, for 0.45:0.88 (KMnO₄:dopamine) molar ratio the optimal compromise was obtained in terms of antimicrobial activity and cytotoxicity, while the 0.1:1.5 ratio (KMnO₄:dopamine) led to higher NO release and implicitly the reduction of the adhesion capacities only for C. albicans, being slightly cytotoxic but with moderate release of LDH. The proposed materials can be used to reduce the adhesion of yeast to the implantable material and thus inhibit the formation of microbial biofilms. Full article

(This article belongs to the Special Issue Novel Approaches to Combat Biofilms Formed on Medical Devices)

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15 pages, 1580 KiB

Open AccessArticle

Laser-Irradiated Chlorpromazine as a Potent Anti-Biofilm Agent for Coating of Biomedical Devices

by Simona Nistorescu, Gratiela Gradisteanu Pircalabioru, Ana-Maria Udrea, Ágota Simon, Mihail Lucian Pascu and Mariana-Carmen Chifiriuc

Coatings 2020, 10(12), 1230; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings10121230 - 16 Dec 2020

Cited by 13 | Viewed by 2305

Abstract

Nowadays, antibiotic resistance has become increasingly common, triggering a global health crisis, immediately needing alternative, including repurposed drugs with potent bactericidal effects. We demonstrated that chlorpromazine aqueous solutions exposed to laser radiation exhibited visible activity against various microorganisms. The aim of this study was to investigate the quantitative antimicrobial activity of chlorpromazine in non-irradiated and 4-h laser irradiated form. Also, we examined the effect of both solutions impregnated on a cotton patch, cannula, and urinary catheter against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa and Escherichia coli. In all experimental versions, the chlorpromazine antimicrobial activity was enhanced by laser exposure. Besides the experimental results, the in silico analyses using molecular docking proved that the improved antimicrobial activity of the irradiated compound was a result of the combined action of the photoproducts on the biological target (s). Our results show that laser radiation could alter the molecular structure of various drugs and their effects, proving to be a promising strategy to halt antibiotic resistance, by repurposing current medicines for new antimicrobial strategies, thereby decreasing the costs and time for the development of more efficient drugs. Full article

(This article belongs to the Special Issue Novel Approaches to Combat Biofilms Formed on Medical Devices)

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Review

Jump to: Research

31 pages, 949 KiB

Open AccessReview

Novel Approaches to Combat Medical Device-Associated BioFilms

by Xin Li, Luyao Sun, Peng Zhang and Yang Wang

Coatings 2021, 11(3), 294; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11030294 - 04 Mar 2021

Cited by 47 | Viewed by 9351

Abstract

Biofilms are aggregates formed as a protective survival state by microorganisms to adapt to the environment and can be resistant to antimicrobial agents and host immune responses due to chemical or physical diffusion barriers, modified nutrient environments, suppression of the growth rate within biofilms, and the genetic adaptation of cells within biofilms. With the widespread use of medical devices, medical device-associated biofilms continue to pose a serious threat to human health, and these biofilms have become the most important source of nosocomial infections. However, traditional antimicrobial agents cannot completely eliminate medical device-associated biofilms. New strategies for the treatment of these biofilms and targeting biofilm infections are urgently required. Several novel approaches have been developed and identified as effective and promising treatments. In this review, we briefly summarize the challenges associated with the treatment of medical device-associated biofilm infections and highlight the latest promising approaches aimed at preventing or eradicating these biofilms. Full article

(This article belongs to the Special Issue Novel Approaches to Combat Biofilms Formed on Medical Devices)

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