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Biointerface Coatings for Biomaterials and Biomedical Applications II
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Biointerface Coatings for Biomaterials and Biomedical Applications II

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 8657

Special Issue Editors

Prof. Dr. Hsien-Yeh Chen

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Guest Editor
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
Interests: biomolecular engineering; vapor-deposition; surface chemistry technique; biomedical coating technology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Peng-Yuan Wang

E-Mail Website
Guest Editor
Institute of Biomedicine and Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences,Shenzhen 518055, China
Interests: biomaterials; nanotechnology; biointerfaces; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to submit your work to this Special Issue on "Biointerface Coatings for Biomaterials and Biomedical Applications II".

In addition to meeting the minimal requirement of biocompatibility, advanced biomaterials have acquired functions, allowing them to directly or indirectly influence specific biological environments. These modifications of biomaterials are generally achieved by establishing an interface layer, i.e., a biointerface coating, to deliver the desired functions. The design of a successful biointerface usually depends on criteria such as controlled presentation of functional biomolecules on the surface, low nonspecific protein adsorption, responsive actions toward external stimuli, multifunctionality, compatibility with micro- to nanofabrication, surface morphology or microstructures, biodegradability, and physical to chemical gradients. Many promising approaches have been realized by existing surface modification technologies based on both physical and chemical methods of rendering fabricated coatings on biomaterials, from basic self-assembly of molecules to top–down construction of bulk materials. Numerous methods exploit a complimentary and/or combinatorial strategy, paving the way to advanced and effective functional coatings for prospective biomaterials.

This Research Topic welcomes discussions related to biointerface coatings, including but not limited to the following:

(1) Molecularly self-assembled coatings;
(2) Surface modifications of coatings;
(3) Layer-by-layer coatings;
(4) Grafted coatings;
(5) Physically adsorbed coatings;
(6) Vapor-deposited coatings
(7) Coatings with chemical activity and/or physical properties;
(8) Innovations of novel coatings for biotechnological applications.

Encouraged forms of submission include original research papers, reviews, and perspective articles.

Prof. Dr. Hsien-Yeh Chen
Prof. Dr. Peng-Yuan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (4 papers)

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Research

10 pages, 2584 KiB  
Article
Design and Molding of Thyroid Cartilage Prosthesis Based on 3D Printing Technology
by Guoqing Zhang, Junxin Li, Chengguang Zhang and Anmin Wang
Coatings 2022, 12(3), 336; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings12030336 - 04 Mar 2022
Cited by 1 | Viewed by 3195
Abstract
The modeling efficiency, matching, and biocompatibility are key factors affecting the surgical success of a personalized thyroid cartilage prosthesis. We performed three-dimensional reconstruction of a thyroid cartilage prosthesis by combining reverse and forward methods, and then completed the prosthesis design with total or [...] Read more.
The modeling efficiency, matching, and biocompatibility are key factors affecting the surgical success of a personalized thyroid cartilage prosthesis. We performed three-dimensional reconstruction of a thyroid cartilage prosthesis by combining reverse and forward methods, and then completed the prosthesis design with total or partial resection using a parametric modeling method. Direct manufacturing was performed using selective laser melting (SLM) molding equipment and TC4 material. The structure of the completed implant unit was optimized. The results show good modeling effects for the thyroid cartilage prosthesis with either total or partial resection by the parametric modeling method. Good matching performance was achieved, with overlap suspension between the pillars that meets the requirements of SLM manufacturing. Additionally, the use of SLM molding to produce the thyroid cartilage prosthesis resulted in less powder adhesion on the surface and no obvious nodulation between the porous pillars, allowing the direct use of the prothesis after simple post-treatment. Overall, these results should facilitate the direct application of personalized implants. Full article
(This article belongs to the Special Issue Biointerface Coatings for Biomaterials and Biomedical Applications II)
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15 pages, 3382 KiB  
Article
Hybrid Surface Nanostructures Using Chemical Vapor Deposition and Colloidal Self-Assembled Patterns for Human Mesenchymal Stem Cell Culture—A Preliminary Study
by Yung-Chiang Liu, Jhe-Wei Jhang, Kun Liu, Haobo Pan, Hsien-Yeh Chen and Peng-Yuan Wang
Coatings 2022, 12(3), 311; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings12030311 - 25 Feb 2022
Cited by 2 | Viewed by 2474
Abstract
Surface coatings are critical in biomaterials and biomedical devices. Chemical vapor deposition (CVD) is a well-known technology for the generation of thin films on a surface. However, the granular structures produced using CVD are rare. Recently, we used PPX-C, an excellent insulating material, [...] Read more.
Surface coatings are critical in biomaterials and biomedical devices. Chemical vapor deposition (CVD) is a well-known technology for the generation of thin films on a surface. However, the granular structures produced using CVD are rare. Recently, we used PPX-C, an excellent insulating material, for granular structure coating using CVD. Colloidal self-assembly is also a well-established method to generate granular structures named colloidal self-assembled patterns (cSAPs). In this study, we combined these two technologies to generate hierarchical granular structures and tested the biophysical effect of these hybrid surfaces on human bone marrow mesenchymal stem cells (hBMSCs). Two CVD-derived granular structures were made using water or glycerin droplets (i.e., CVD or GlyCVD surfaces). Water drops generate porous particles, while glycerin drops generate core–shell particles on the surface. These particles were dispersed randomly on the surface with sizes ranging from 1 to 20 μm. These CVD surfaces were hydrophobic (WCA ~ 80–110 degrees). On the other hand, a binary colloidal crystal (BCC), one type of cSAPs, composed of 5 μm Si and 400 nm carboxylated polystyrene (PSC) particles, had a close-packed structure and a hydrophilic surface (WCA ~ 45 degrees). The hybrid surfaces (i.e., CVD-BCC and GlyCVD-BCC) were smooth (Ra ~ 1.1–1.5 μm) and hydrophilic (WCA ~ 50 degrees), indicating a large surface coverage of BCC dominating the surface property. The hybrid surfaces were expected to be slightly negatively charged due to naturally charged CVD particles and negatively charged BCC particles. Cell adhesion was reduced on the hybrid surfaces, leading to an aggregated cell morphology, without reducing cell activity, compared to the flat control after 5 days. qPCR analysis showed that gene expression of type II collagen (COL2) was highly expressed on the GlyCVD-BCC without chemical induction after 3 and 14 days compared to the flat control. This proof-of-concept study demonstrates the potential of combining two technologies to make hybrid structures that can modulate stem cell attachment and differentiation. Full article
(This article belongs to the Special Issue Biointerface Coatings for Biomaterials and Biomedical Applications II)
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15 pages, 11175 KiB  
Article
Guiding Stem Cell Differentiation and Proliferation Activities Based on Nanometer-Thick Functionalized Poly-p-xylylene Coatings
by Chih-Yu Wu, Yu-Chih Chiang, Jane Christy, Abel Po-Hao Huang, Nai-Yun Chang, Wenny, Yu-Chih Chiu, Yen-Ching Yang, Po-Chun Chen, Peng-Yuan Wang and Hsien-Yeh Chen
Coatings 2021, 11(5), 582; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11050582 - 17 May 2021
Viewed by 2054
Abstract
Modifications of biomaterials based on the combination of physical, chemical, and biological cues for manipulating stem cell growth are needed for modern regenerative medicine. The exploitation of these sophisticated modifications remains a challenge, including substrate limitation, biocompatibility, and versatile and general cues for [...] Read more.
Modifications of biomaterials based on the combination of physical, chemical, and biological cues for manipulating stem cell growth are needed for modern regenerative medicine. The exploitation of these sophisticated modifications remains a challenge, including substrate limitation, biocompatibility, and versatile and general cues for stem cell activities. In this report, a vapor-phase coating technique based on the functionalization of poly-p-xylylene (PPX) was used to generate a surface modification for use with stem cells in culture. The coating provided the ability for covalent conjugation that immobilized bone morphogenetic protein 2 (BMP-2) and fibroblast growth factor 2 (FGF-2), and the modified coating surfaces enabled direct stem cell differentiation and controlled proliferation because of the specific activities. The ligations were realized between the growth factors and the maleimide-modified surface, and the conjugation reactions proceeded with high specificity and rapid kinetics under mild conditions. The conjugation densities were approximately 140 ng·cm−2 for BMP-2 and 155 ng·cm−2 for FGF-2. Guiding the activities of the human adipose-derived stem cells (hADSCs) was achieved by modifying surfaces to promote the hADSC differentiation capacity and proliferation rate. The reported coating system demonstrated biocompatibility, substrate-independent conformity, and stability, and it could provide an effective and versatile interface platform for further use in biomedical applications. Full article
(This article belongs to the Special Issue Biointerface Coatings for Biomaterials and Biomedical Applications II)
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12 pages, 3686 KiB  
Article
Vapor-Phase Fabrication of a Maleimide-Functionalized Poly-p-xylylene with a Three-Dimensional Structure
by Shu-Man Hu, Chin-Yun Lee, Yu-Ming Chang, Jia-Qi Xiao, Tatsuya Kusanagi, Ting-Ying Wu, Nai-Yun Chang, Jane Christy, Ya-Ru Chiu, Chao-Wei Huang, Yen-Ching Yang, Yu-Chih Chiang and Hsien-Yeh Chen
Coatings 2021, 11(4), 466; https://0-doi-org.brum.beds.ac.uk/10.3390/coatings11040466 - 16 Apr 2021
Cited by 2 | Viewed by 2246
Abstract
A vapor-phase process, involving the sublimation of an ice substrate/template and the vapor deposition of a maleimide-functionalized poly-p-xylylene, has been reported to synthesize an advanced porous material, with readily clickable chemical interface properties, to perform a Michael-type addition of a maleimide [...] Read more.
A vapor-phase process, involving the sublimation of an ice substrate/template and the vapor deposition of a maleimide-functionalized poly-p-xylylene, has been reported to synthesize an advanced porous material, with readily clickable chemical interface properties, to perform a Michael-type addition of a maleimide functionality for conjugation with a thiol group. In contrast to the conventional chemical vapor deposition of poly-p-xylylenes on a solid surface that forms thin film coatings, the process reported herein additionally results in deposition on a dynamic and sublimating ice surface (template), rendering the construction of a three-dimensional, porous, maleimide-functionalized poly-p-xylylene. The process seamlessly exploits the refined chemical vapor deposition polymerization from maleimide-substituted [2,2]paracyclophane and ensures the preservation and transformation of the maleimide functionality to the final porous poly-p-xylylene products. The functionalization and production of a porous maleimide-functionalized poly-p-xylylene were completed in a single step, thus avoiding complicated steps or post-functionalization procedures that are commonly seen in conventional approaches to produce functional materials. More importantly, the equipped maleimide functionality provides a rapid and efficient route for click conjugation toward thiol-terminated molecules, and the reaction can be performed under mild conditions at room temperature in a water solution without the need for a catalyst, an initiator, or other energy sources. The introduced vapor-based process enables a straightforward synthesis approach to produce not only a pore-forming structure of a three-dimensional material, but also an in situ-derived maleimide functional group, to conduct a covalent click reaction with thiol-terminal molecules, which are abundant in biological environments. These advanced materials are expected to have a wide variety of new applications. Full article
(This article belongs to the Special Issue Biointerface Coatings for Biomaterials and Biomedical Applications II)
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