Computation

When culturing cells in space or under altered gravity conditions on Earth to investigate the impact of gravity, their adhesion and organoid formation capabilities change. In search of a target where the alteration of gravity force could have this impact, we investigated p130cas/BCAR1 and its interactions more thoroughly, particularly as its activity is sensitive to applied forces. This protein is well characterized regarding its role in growth stimulation and adhesion processes. To better understand BCAR1′s force-dependent scaffolding of other proteins, we studied its interactions with proteins we had detected by proteome analyses of MCF-7 breast cancer and FTC-133 thyroid cancer cells, which are both sensitive to exposure to microgravity and express BCAR1. Using linked open data resources and our experiments, we collected comprehensive information to establish a semantic knowledgebase and analyzed identified proteins belonging to signaling pathways and their networks. The results show that the force-dependent phosphorylation and scaffolding of BCAR1 influence the structure, function, and degradation of intracellular proteins as well as the growth, adhesion and apoptosis of cells similarly to exposure of whole cells to altered gravity. As BCAR1 evidently plays a significant role in cell responses to gravity changes, this study reveals a clear path to future research performing phosphorylation experiments on BCAR1. Full article

In this study, a new methodology is proposed to perform optimal selection of conductors in three-phase distribution networks through a discrete version of the metaheuristic method of vortex search. To represent the problem, a single-objective mathematical model with a mixed-integer nonlinear programming (MINLP) structure is used. As an objective function, minimization of the investment costs in conductors together with the technical losses of the network for a study period of one year is considered. Additionally, the model will be implemented in balanced and unbalanced test systems and with variations in the connection of their loads, i.e., $\Delta -$ and $Y-$connections. To evaluate the costs of the energy losses, a classical backward/forward three-phase power-flow method is implemented. Two test systems used in the specialized literature were employed, which comprise 8 and 27 nodes with radial structures in medium voltage levels. All computational implementations were developed in the MATLAB programming environment, and all results were evaluated in DigSILENT software to verify the effectiveness and the proposed three-phase unbalanced power-flow method. Comparative analyses with classical and Chu & Beasley genetic algorithms, tabu search algorithm, and exact MINLP approaches demonstrate the efficiency of the proposed optimization approach regarding the final value of the objective function. Full article

The matched interface and boundary method (MIB) and ghost fluid method (GFM) are two well-known methods for solving elliptic interface problems. Moreover, they can be coupled with efficient time advancing methods, such as the alternating direction implicit (ADI) methods, for solving time-dependent partial differential equations (PDEs) with interfaces. However, to our best knowledge, all existing interface ADI methods for solving parabolic interface problems concern only constant coefficient PDEs, and no efficient and accurate ADI method has been developed for variable coefficient PDEs. In this work, we propose to incorporate the MIB and GFM in the framework of the ADI methods for generalized methods to solve two-dimensional parabolic interface problems with variable coefficients. Various numerical tests are conducted to investigate the accuracy, efficiency, and stability of the proposed methods. Both the semi-implicit MIB-ADI and fully-implicit GFM-ADI methods can recover the accuracy reduction near interfaces while maintaining the ADI efficiency. In summary, the GFM-ADI is found to be more stable as a fully-implicit time integration method, while the MIB-ADI is found to be more accurate with higher spatial and temporal convergence rates. Full article

Feature extraction plays an important role in machine learning for signal processing, particularly for low-dimensional data visualization and predictive analytics. Data from real-world complex systems are often high-dimensional, multi-scale, and non-stationary. Extracting key features of this type of data is challenging. This work proposes a novel approach to analyze Epileptic EEG signals using both wavelet power spectra and functional principal component analysis. We focus on how the feature extraction method can help improve the separation of signals in a low-dimensional feature subspace. By transforming EEG signals into wavelet power spectra, the functionality of signals is significantly enhanced. Furthermore, the power spectra transformation makes functional principal component analysis suitable for extracting key signal features. Therefore, we refer to this approach as a double feature extraction method since both wavelet transform and functional PCA are feature extractors. To demonstrate the applicability of the proposed method, we have tested it using a set of publicly available epileptic EEGs and patient-specific, multi-channel EEG signals, for both ictal signals and pre-ictal signals. The obtained results demonstrate that combining wavelet power spectra and functional principal component analysis is promising for feature extraction of epileptic EEGs. Therefore, they can be useful in computer-based medical systems for epilepsy diagnosis and epileptic seizure detection problems. Full article

The article describes the original information technology of the algorithmic trading, designed to solve the problem of forming the optimal portfolio of trade strategies. The methodology of robust optimization, using the Ledoit–Wolf shrinkage method for obtaining stable estimates of the covariance matrix of algorithmic strategies, was used for the formation of a portfolio of trade strategies. The corresponding software was implemented by SAS OPTMODEL Procedure. The paper deals with a portfolio of trade strategies built for highly-profitable, but also highly risky financial tools—cryptocurrencies. Available bitcoin assets were divided into a corresponding proportion for each of the recommended portfolio strategies, and during the selected period (one calendar month) were used for this research. The portfolio of trade strategies is rebuilt at the end of the period (every month) based on the results of trade during the period, in accordance with the conditions of risk minimizing or income maximizing. Trading strategies work in parallel, being in a state of waiting for a relevant trading signal. Strategies can be changed by moving the parameters in accordance with the current state of the financial market, removed if ineffective, and replaced where necessary. The efficiency of using a robust decision-making method in the context of uncertainty regarding cryptocurrency trading was confirmed by the results of real trading for the Bitcoin/Dollar pair. Implementation of the offered information technology in electronic trading systems will allow risk reduction as a result of making incorrect decisions or delays in making decisions in a systemic trading. Full article

The aim of the present paper is to improve an existing blind image deblurring algorithm, based on an independent component learning paradigm, by manifold calculus. The original technique is based on an independent component analysis algorithm applied to a set of pseudo-images obtained by Gabor-filtering a blurred image and is based on an adapt-and-project paradigm. A comparison between the original technique and the improved method shows that independent component learning on the unit hypersphere by a Riemannian-gradient algorithm outperforms the adapt-and-project strategy. A comprehensive set of numerical tests evidenced the strengths and weaknesses of the discussed deblurring technique. Full article

Problems in perforated media are complex and require high resolution grid construction to capture complex irregular perforation boundaries leading to the large discrete system of equations. In this paper, we develop a multiscale model reduction technique based on the Discontinuous Galerkin Generalized Multiscale Finite Element Method (DG-GMsFEM) for problems in perforated domains with non-homogeneous boundary conditions on perforations. This method implies division of the perforated domain into several non-overlapping subdomains constructing local multiscale basis functions for each. We use two types of multiscale basis functions, which are constructed by imposing suitable non-homogeneous boundary conditions on subdomain boundary and perforation boundary. The construction of these basis functions contains two steps: (1) snapshot space construction and (2) solution of local spectral problems for dimension reduction in the snapshot space. The presented method is used to solve different model problems: elliptic, parabolic, elastic, and thermoelastic equations with non-homogeneous boundary conditions on perforations. The concepts for coarse grid construction and definition of the local domains are presented and investigated numerically. Numerical results for two test cases with homogeneous and non-homogeneous boundary conditions are included, as well. For the case with homogeneous boundary conditions on perforations, results are shown using only local basis functions with non-homogeneous boundary condition on subdomain boundary and homogeneous boundary condition on perforation boundary. Both types of basis functions are needed in order to obtain accurate solutions, and they are shown for problems with non-homogeneous boundary conditions on perforations. The numerical results show that the proposed method provides good results with a significant reduction of the system size. Full article

The density functional theory proposed earlier for excited states of Coulomb systems is discussed. The localized Hartree–Fock (LHF) and the Krieger, Li, and Iafrate (KLI) methods combined with correlation are generalized for excited states. Illustrative examples include some highly excited states of Li and Na atoms. Full article

DiGriPy is a newly developed Python tool for the simulation of district heating networks published as open-source software in GitHub and offered as a Python package on PyPI. It enables the user to easily build a network model, run large-scale demand time series, and automatically compare different temperature-control conditions. In this paper, implementation details and usage instructions are given. Tests showing the results of different scenarios are presented and interpreted. Full article

Countries around the world generate electricity from renewable resources to decarbonise their societies and reduce global warming. Some countries have already outlined their wishes to produce a part of their total energy consumption from renewable sources in the coming years and gradually reduce the use of nuclear energy and fossil fuel in favour of cleaner fuels. While renewable energies are significant factors in tackling climate change, the parameters that can influence their performance should be analysed in detail during the design process. One of these parameters is the foundation of an offshore wind turbine. Offshore wind turbines allow more energy to be produced than an onshore installation, and do not have any harmful effects on human beings, while their geotechnical aspects need to be clearly determined in advance. In this study, the influential parameters such as soil type, the number of bolts in the design, and the size of the structure were analysed using the finite element method for three different designs. The simulations showed that some soil properties, such as cohesion, do not influence the results, while Young’s modulus has a large influence on the designs. Additionally, the results of this study showed that the maximum stress concentrations are at the bolts and connection joints where they are too close to the steel’s yield stress. It also proves that the non-elastic behaviour of the soil does not require to be assigned for such analyses and it can be simplified only with its elastic behaviour. The embedded length affects the lateral displacement, while the number of bolts influences the structure’s resistance to external loads. Full article

The issue of the robust exponential passivity analysis for uncertain neutral-type neural networks with mixed interval time-varying delays is discussed in this work. For our purpose, the lower bounds of the delays are allowed to be either positive or zero adopting the combination of the model transformation, various inequalities, the reciprocally convex combination, and suitable Lyapunov–Krasovskii functional. A new robust exponential passivity criterion is received and formulated in the form of linear matrix inequalities (LMIs). Moreover, a new exponential passivity criterion is also examined for systems without uncertainty. Four numerical examples indicate our potential results exceed the previous results. Full article

Radio frequency identification (RFID) is widely used in several contexts, such as logistics, supply chains, asset tracking, and health, among others, therefore drawing the attention of many researchers. This paper presents a review of the most cited topics regarding RFID focused on applications, security, and privacy. A total of 62,685 records were downloaded from the Web of Science (WoS) and Scopus core databases and processed, reconciling the datasets to remove duplicates, resulting in 40,677 unique elements. Fundamental indicators were extracted and are presented, such as the citation number, average growth rate, and average number of documents per year. We extracted the top topics and reviewed the relevant indicators using a free Python tool, ScientoPy. The results are discussed in the following sections: the first is the Applications Section, whose subsections are the Internet of Things (IoT), Supply Chain Management, Localization, Traceability, Logistics, Ubiquitous Computing, Healthcare, and Access Control; the second is the Security and Privacy section, whose subsections are Authentication, Privacy, and Ownership Transfer; finally, we present the Discussion section. This paper intends to provide the reader with a global view of the current status of trending RFID topics and present different analyses from different perspectives depending on motivations or background. Full article

The rapid growth in biomedical datasets has generated high dimensionality features that negatively impact machine learning classifiers. In machine learning, feature selection (FS) is an essential process for selecting the most significant features and reducing redundant and irrelevant features. In this study, an equilibrium optimization algorithm (EOA) is used to minimize the selected features from high-dimensional medical datasets. EOA is a novel metaheuristic physics-based algorithm and newly proposed to deal with unimodal, multi-modal, and engineering problems. EOA is considered as one of the most powerful, fast, and best performing population-based optimization algorithms. However, EOA suffers from local optima and population diversity when dealing with high dimensionality features, such as in biomedical datasets. In order to overcome these limitations and adapt EOA to solve feature selection problems, a novel metaheuristic optimizer, the so-called improved equilibrium optimization algorithm (IEOA), is proposed. Two main improvements are included in the IEOA: The first improvement is applying elite opposite-based learning (EOBL) to improve population diversity. The second improvement is integrating three novel local search strategies to prevent it from becoming stuck in local optima. The local search strategies applied to enhance local search capabilities depend on three approaches: mutation search, mutation–neighborhood search, and a backup strategy. The IEOA has enhanced the population diversity, classification accuracy, and selected features, and increased the convergence speed rate. To evaluate the performance of IEOA, we conducted experiments on 21 biomedical benchmark datasets gathered from the UCI repository. Four standard metrics were used to test and evaluate IEOA’s performance: the number of selected features, classification accuracy, fitness value, and p-value statistical test. Moreover, the proposed IEOA was compared with the original EOA and other well-known optimization algorithms. Based on the experimental results, IEOA confirmed its better performance in comparison to the original EOA and the other optimization algorithms, for the majority of the used datasets. Full article

This paper addresses the phase-balancing problem in three-phase power grids with the radial configuration from the perspective of master–slave optimization. The master stage corresponds to an improved version of the Chu and Beasley genetic algorithm, which is based on the multi-point mutation operator and the generation of solutions using a Gaussian normal distribution based on the exploration and exploitation schemes of the vortex search algorithm. The master stage is entrusted with determining the configuration of the phases by using an integer codification. In the slave stage, a power flow for imbalanced distribution grids based on the three-phase version of the successive approximation method was used to determine the costs of daily energy losses. The objective of the optimization model is to minimize the annual operative costs of the network by considering the daily active and reactive power curves. Numerical results from a modified version of the IEEE 37-node test feeder demonstrate that it is possible to reduce the annual operative costs of the network by approximately 20% by using optimal load balancing. In addition, numerical results demonstrated that the improved version of the CBGA is at least three times faster than the classical CBGA, this was obtained in the peak load case for a test feeder composed of 15 nodes; also, the improved version of the CBGA was nineteen times faster than the vortex search algorithm. Other comparisons with the sine–cosine algorithm and the black hole optimizer confirmed the efficiency of the proposed optimization method regarding running time and objective function values. Full article

In this paper, we investigate wave attenuation caused by mangroves as a porous media. A 1-D mathematical model is derived by modifying the shallow water equations (SWEs). Two approaches are used to involve the existing of mangrove: friction term and diffusion term. The model will be solved analytically using the separation of variables method and numerically using a staggered finite volume method. From both methods, wave transmission coefficient will be obtained and used to observe the damping effect induced by the porous media. Several comparisons are shown to examine the accuracy and robustness of the derived numerical scheme. The results show that the friction coefficient, diffusion coefficient and vegetation’s length have a significant effect on the transmission coefficient. Moreover, numerical observation is extended to a 2-D SWEs, where we conduct a numerical simulation over a real bathymetry profile. The results from the 2-D numerical scheme will be validated using the data obtained from the field measurement which took place in Demak, Central Java, Indonesia. The results from this research will be beneficial to determine the characteristics of porous structures used for coastal protection. Full article

The present work highlights the capacity of disparate lattice Boltzmann strategies in simulating natural convection and heat transfer phenomena during the unsteady period of the flow. Within the framework of Bhatnagar-Gross-Krook collision operator, diverse lattice Boltzmann schemes emerged from two different embodiments of discrete Boltzmann expression and three distinct forcing models. Subsequently, computational performance of disparate lattice Boltzmann strategies was tested upon two different thermo-hydrodynamics configurations, namely the natural convection in a differentially-heated cavity and the Rayleigh-Bènard convection. For the purposes of exhibition and validation, the steady-state conditions of both physical systems were compared with the established numerical results from the classical computational techniques. Excellent agreements were observed for both thermo-hydrodynamics cases. Numerical results of both physical systems demonstrate the existence of considerable discrepancy in the computational characteristics of different lattice Boltzmann strategies during the unsteady period of the simulation. The corresponding disparity diminished gradually as the simulation proceeded towards a steady-state condition, where the computational profiles became almost equivalent. Variation in the discrete lattice Boltzmann expressions was identified as the primary factor that engenders the prevailed heterogeneity in the computational behaviour. Meanwhile, the contribution of distinct forcing models to the emergence of such diversity was found to be inconsequential. The findings of the present study contribute to the ventures to alleviate contemporary issues regarding proper selection of lattice Boltzmann schemes in modelling fluid flow and heat transfer phenomena. Full article

Social media applications have been increasingly gaining significant attention from online education and training platforms. Social networking tools provide multiple advantages for communicating, exchanging opinions, and discussing specific issues. Social media also helps to improve the processes of teaching and learning through sharing educational programs. In this study, we used a quantitative research technique based on the partial least-squares (PLS) linear regression method to determine the influence of using social media as an online discussion and communication platform for academic purposes by assessing the relationships among the skills obtained through social media, the usage of social media, and the purpose of social media. A total of 200 students participated in this study (88% female and 12% males), and a purposive sampling technique was used to select a suitable population for the study. The results show that 61.5% of the participants use the web daily for more than five hours, mainly for social communication (meaningful dialog and discussion skills) and entertainment. The students agreed that social media develops their creative thinking, but it has no positive impact on their academic performance. Full article

Gas turbine performance is closely linked to the turbine inlet temperature, which is limited by the turbine guide vanes ability to withstand the massive thermal loads. Thus, steam cooling has been introduced as an advanced cooling technology to improve the efficiency of modern high-temperature gas turbines. This study compares the cooling performance of compressed air and steam in the renowned radially cooled NASA C3X turbine guide vane, using a numerical model. The conjugate heat transfer (CHT) model is based on the RANS-method, where the shear stress transport (SST) $k-\omega$ model is selected to predict the effects of turbulence. The numerical model is validated against experimental pressure and temperature distributions at the external surface of the vane. The results are in good agreement with the experimental data, with an average error of 1.39% and 3.78%, respectively. By comparing the two coolants, steam is confirmed as the superior cooling medium. The disparity between the coolants increases along the axial direction of the vane, and the total volume average temperature difference is 30 K. Further investigations are recommended to deal with the local hot-spots located near the leading- and trailing edge of the vane. Full article