Dear colleagues,

Modern clinical oncology continues to experience a rapid and remarkable transformation. We have an ever-increasing understanding of the cellular mechanisms that control the progression of disease, we have systemic therapies that allow us to attack cancer at a molecular level, both via a direct attack upon the internal mechanisms of the cell, as well as by harnessing the body’s own immune system to target and to destroy the disease. In parallel with this, advances in imaging technology have enabled us to identify malignancy earlier, while advances in computing power have enable us to treat even very small, mobile cancers more precisely than ever before.

Stereotactic Body Radiation Therapy (SBRT) implies the delivery of large doses of radiation to very small volumes, in a very short period of time, using sophisticated technology to plan and to deliver the treatment. SBRT has become a valuable adjunct to standard surgery and chemotherapy in some situations, and a viable alternative to surgery in other situations. In a very short time, it has grown from being a highly specialized intervention practiced by only a few centres, becoming a modern standard-of-care at most academic centres. In doing so, SBRT has offered improved outcomes to our patients, and exciting new opportunities to our clinicians and researchers. The burden of cancer continues to grow as and our population continues to age. SBRT is a powerful weapon in our battle against cancers of all types.

The availability of SBRT will continue to expand, along with the indications for its use, and therefore it is critical for radiation oncologists, as well as the larger body of oncologists in general, to understand this exciting treatment modality as thoroughly as possible. This Special Issue therefore aims to provide a thorough review of SBRT, examining its genesis, clinical applications and its emerging relationship to other oncologic treatment modalities, pointing the way forward to the next decade and beyond for this novel, exciting treatment.

Dr. Brian Yaremko
Guest Editor

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• stereotactic radiotherapy
• stereotactic ablative body radiotherapy