Special Issue "New Insights in Pediatric Dermatopathology"

A special issue of Dermatopathology (ISSN 2296-3529). This special issue belongs to the section "Pediatric Dermatopathology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Sylvie Fraitag
E-Mail Website
Guest Editor
Department of Pathology, Necker Hospital for Sick Children, 75015 Paris, France
Interests: paediatrics; genodermatoses; pediatric inflammatory disorders; children cutaneous tumours; superficial paediatric soft tissue tumours; melanocytic proliferation in children

Special Issue Information

Dear Colleagues,

Paediatric Dermatology and Dermatopathology are expanding subspecialities that cover a wide range of disorders including genodermatoses, cutaneous and subcutaneous tumours and inflammatory disorders. Even though adults and children share a lot of skin diseases, some disorders are mostly observed in childhood, some of them even being specific to this age group. That is why dermatopathologists are more and more called upon to deal with skin biopsies in neonates, infants or children. The aim of this Special Issue is to cover some important fields in which knowledge has improved greatly in recent times, sometimes thanks to the development of new markers and molecular biology (i.e., melanocytic and histiocytic disorders), and sometimes just because young dermatologists are now less reluctant to perform a biopsy on a child. Moreover, clinicopathological correlations and multidisciplinary meetings have allowed the emergences of new classifications, such as in vascular anomalies or development anomalies. To cover this, we have asked top specialists to write review articles on important fields of paediatric dermatopathology. In addition, we thought it useful to add some practical articles on emergency situations such as “how to deal with a skin biopsy on an infant with bullous eruption” and “what to look out for in a neonate with multiple nodules” written by authors experienced in skin biopsies on small children.

Prof. Dr. Sylvie Fraitag
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dermatopathology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pediatric dermatopathology
  • pediatric vascular tumors
  • childhood melanoma
  • auto-inflammatory disorders
  • nodules
  • neonates
  • infants
  • bullous eruption in infancy
  • cysts
  • histiocytosis
  • keratinization disorders
  • auto-inflammatory diseases

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Update in Superficial Spindle-Cell Tumors in Children
Authors: Philippe Drabent 1,2; Sylvie Fraitag 1
1 Necker-Enfants Malades Hospital, Paris, France
2 Sorbonne University, Paris, France
Abstract: Cutaneous and subcutaneous spindle-cell neoplasms in children are often diagnostically challenging, with potential therapeutic and prognostic implications. If the right diagnoses of dermatofibrosarcoma protuberans or infantile fibrosarcoma are paramount, pathologists should not ignore a number of diagnostic pitfalls, mostly rare tumors with a completely different clinical outcome. In the last decade, a spectrum of novel entities has been described and with the contribution of molecular biology, they have shaped a new landscape of spindle-cell tumors. Here, we review the most noteworthy of these neoplasms with a focus on their histological similarities: fibroblastic connective tissue nevus, medallion-like dermal dendrocyte hamartoma or plaque-like CD34-positive dermal fibroma, which share common features with the fibrous hamartoma of infancy; lipofibromatosis and lipofibromatosis-like neural tumor; and plexiform myofibroblastoma, a recently described neoplasm which should be distinguished from plexiform fibrohistiocytic tumor. Similarities are also found in the genetics of some of these tumors, in particular gene rearrangements involving NTRK3 or NTRK1, which are not only essential to the differential diagnosis of infantile fibrosarcoma but are also of diagnostic value for lipofibromatosis-like neural tumors. The more recently described RET gene fusions will be discussed as well.

Title: How to Deal with Skin Biopsy in an Infant with Blisters?
Authors: Stéphanie Leclerc-Mercier
Affiliation: Department of Pathology and Reference Center for Genodermatoses (MAGEC center) Necker-Enfants Malades Hospital, Paris centre University, France
Abstract: The onset of blisters in a neonate or an infant is often a source of great concern for both parents and physicians. A blistering rash can reveal a wide range of diseases with various backgrounds (infectious, genetic, autoimmune, drug-related, traumatic, etc.), so the challenge for the dermatologist and the pediatrician is to determine quickly the etiology among benign causes and life-threatening disorders for a better management of the patient. Clinical presentation can provide orientation for the diagnosis, but skin biopsy is often necessary in determining the cause of blister formation. In this article, we will provide information on the skin biopsy technique and discuss the clinical orientation in the case of a neonate or infant with a blistering eruption, with a focus on the histology for each etiology.

Title: Histological Patterns of Skin Lesions in Tuberous Sclerosis Complex: A Panorama
Authors: Marine Cascarino 1; Stéphanie Leclerc-Mercier 2
1 Department of Pathology, Paris Saint-Joseph Hospital Group, Paris, France
2 Department of Pathology and Reference Center for Genodermatoses (MAGEC center) Necker-Enfants Malades Hospital, Paris centre University, France
Abstract: Tuberous Sclerosis Complex (TSC) is a multisystem genetic disease characterized by cutaneous and extracutaneous hamartomas. The diagnosis is based on the association of major and minor criteria, defined by a consensus conference updated in 2012. Dermatologic evaluation is critical because seven diagnostic criteria are dermatologic: four major (hypomelanotic macules, angiofibroma or fibrous cephalic plaques, ungual fibromas, shagreen patches) and three minor criteria (confetti skin lesions, dental enamel pits, intraoral fibromas). Skin biopsy is commonly performed to assert the diagnosis of TSC when the clinical aspect is atypical. Histopathology of TSC cutaneous lesions have been poorly reported until now. In this article, we review the histologic features described in the literature and share our experience of TSC skin biopsies in our pediatric hospital specialized in genetic disorders. Both hypomelanotic lesions and cutaneous hamartoma (angiofibroma/fibrous cephalic plaques, ungual fibromas, shagreen patches) are discussed, including the recent entity called folliculocystic and collagen hamartoma, with a special emphasis on helpful clues for TSC in such lesions.

Title: What to Look Out for in a Neonate with Multiple Papulo-Nodular Cutaneous Lesions
Authors: Sylvie Fraitag
Affiliation: Hôpital Necker-Enfants Malades, APHP, Sorbonne University, Paris, France
Abstract: The presence, at birth, of multiple cutaneous papulo-nodular lesions can indicate various benign or malignant disorders. Although the clinical appearance of these lesions, particularly their color and consistency, may steer the clinician towards one diagnosis or another (multiple hemangiomas, xanthogranulomas or metastatic neuroblastoma), only a biopsy with a histopathological examination will confirm it. In neonates, an accurate and rapid diagnosis is crucial because malignancy, such as leukemia cutis or metastatic neuroblastoma, can occur. The different disorders that may be encountered at this age and that may manifest as multiple cutaneous lesions will be discussed.

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