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Special Issue Editors

Dr. Katharina Hess

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Guest Editor

Department of Pathology, UKSH, Kiel, Germany
Interests: morphological; molecular pathological and surgical diagnostic; therapy of meningiomas

Dr. Charlotte Flüh

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Guest Editor

1. Department of Neurosurgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, Haus D, 24105 Kiel, Germany
2. Cellular Neurosciences, Max DelbrückCenter for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Straße 10, 13125 Berlin, Germany
Interests: neurosurgical therapy; perioperative management of patients with meningiomas; solid intracranial tumors as well as molecular pathological analysis of intracranial tumors and their microenvironment

Special Issue Information

Dear Colleagues,

Meningiomas are the most common intracranial tumours in adults. However, although the majority of meningiomas are classified as benign by the WHO classification, the clinical management of patients with meningiomas is challenging due to the high recurrence rate of patients and the balance between treatment of the tumour and prevention of neurologic damage from the treatment itself. Therefore, further development of already established diagnostic tools and therapies, perioperative management and postoperative surveillance but also research of alternative treatment modalities seem to be urgent.

The aim of this Special Issue is to improve clinical management from preoperative patient assessment, tumour resection, diagnosis, surgical/radiotherapeutic/pharmacologic therapy and evaluation of long-term outcomes of patients with meningiomas. This Special Issue aims to provide a comprehensive overview of the aetiology, diagnosis and therapy of meningiomas covering all aspects of this research, ranging from molecular pathogenesis of meningioma and tumour progression to novelties in radiological imaging.

The Special Issue intends to cover not only experimental studies with the development and evaluation of new experimental models but also clinical studies including the evaluation of new therapeutic approaches.

Dr. Katharina Hess
Dr. Charlotte Flüh
Guest Editors

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Keywords

atypical and anaplastic meningioma
reccurrence rate
clinical management of patients with meningioma
molecular biomarkers
imaging techniques
therapeutics

Published Papers (2 papers)

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Research

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19 pages, 3638 KiB

Open AccessArticle

Inflammatory Tumor Microenvironment in Cranial Meningiomas: Clinical Implications and Intraindividual Reproducibility

by Johannes Wach, Tim Lampmann, Ági Güresir, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Marieta Toma, Michael Hölzel and Erdem Güresir

Diagnostics 2022, 12(4), 853; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12040853 - 30 Mar 2022

Cited by 3 | Viewed by 1954

Abstract

The MIB-1 index was demonstrated to be significantly correlated to meningioma recurrence. However, to date, the relationship of the intraindividual course of the MIB-1 index and the growth fraction, respectively, to clinical tumor recurrence has not been demonstrated in cranial WHO grade 1 and 2 meningiomas. In the present paper, we compare the MIB-1 indices of 16 solely surgically treated primary meningiomas and their recurrent tumors regarding the course of the MIB-1 indices, time to recurrence, reproducibility and factors influencing the intraindividual MIB-1 indices. Regression analyses revealed (1) a strong intra-lab reproducibility (r = 0.88) of the MIB-1 index at the second versus the first operation, corresponding to a constant intrinsic growth activity of an individual meningioma, (2) a significant inverse correlation of both primary (r = −0.51) and secondary (r = −0.70) MIB-1 indices to time to recurrence, and (3) male sex, low plasma fibrinogen and diffuse CD68⁺ macrophage infiltrates contribute to an increase in the MIB-1 index. A strong intraindividual reproducibility of the MIB-1 index and a direct relationship of the MIB-1 index to the time to recurrence were observed. Individual MIB-1 indices might be used for tailored follow-up imaging intervals. Further research on the role of macrophages and inflammatory burden in the regrowth potential of meningiomas are needed. Full article

(This article belongs to the Special Issue Advances in Clinical and Molecular Diagnostics of Meningiomas)

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6 pages, 1006 KiB

Open AccessCase Report

Visual Aura Secondary to Supratentorial Lipomatous Meningioma: A Rare Case Report

by Pierfrancesco Lapolla, Placido Bruzzaniti, Giuseppa Zancana, Antonella Stoppacciaro, Michela Relucenti, Rui Chen, Xiaobo Li, Andrea Mingoli, Alessandro Frati and Pietro Familiari

Diagnostics 2022, 12(2), 365; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12020365 - 01 Feb 2022

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Abstract

Background/Aim: Lipomatous meningioma is a rare type of meningioma that is formed as the result of an accumulation of lipids inside the cell due to metabolic activity dysregulation. It differs from other types of meningiomas in its radiological and immunohistochemical characteristics. We report a rare case of a patient treated in our department for this particular type of meningioma who developed a type of migraine with the aura component as the first clinical symptom. Case Report: A 55-year-old woman presented with a migraine and reported having phosphenes in recent years. Head Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scans were performed; these showed an extensive hypodense and hypointense formation located in the left parieto-occipital region. This formation was implanted in the tentorium region, with a prevailingly adipose-type signal intensity. The patient underwent an occipital craniotomy with the total removal of the lesion. The histological examination indicated a lipomatous metaplastic meningioma. Conclusion: We reported the first case of a lipomatous meningioma presenting with a migraine with a visual aura. Seizures and headaches can be included as possible symptoms. According to the current literature, lipomatous meningiomas affect women more commonly than men. The patient of our reported case presented visual disturbances in the form of a visual aura, which occurred 10 years before finding the meningioma, and surgery dramatically improved the symptoms and quality of life. Full article

(This article belongs to the Special Issue Advances in Clinical and Molecular Diagnostics of Meningiomas)

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