Diagnosis for Psychosis and Personality Disorders: Risk Factors and Early Detection

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 38262

Special Issue Editor


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Guest Editor
Center for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy
Interests: personality disorders; interpersonal psychotherapy; antipsychotics; brain imaging

Special Issue Information

Dear Colleagues,

Early diagnosis represents a key issue of modern clinical psychiatry. Evidence shows how an early detection based on prodromal signs and symptoms is required to ensure a precocious therapeutic intervention, which significantly ameliorates the course and outcome of major psychiatric disorders. This is true especially when considering early onset diseases, such as psychosis and severe personality disorders (i.e., borderline personality disorder), which start during adolescence or young adulthood but whose diagnosis and treatment are often delayed. This unfortunately results in a worse impact on global functioning and quality of life. In order to facilitate a prompt detection of both these conditions, risk factors represent an important tool for clinicians, useful to help identify subjects who may develop the disease and therefore might benefit from early psychosocial and, in some cases, pharmacological intervention. These subjects must be monitored in case prodromal symptoms should arise, which, if left untreated, constitute a negative predictive factor for the outcome of the disease.

Dr. Silvio Bellino
Guest Editor

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Keywords

  • psychosis
  • personality disorders
  • diagnosis
  • risk factors
  • early detection
  • early onset
  • outcome

Published Papers (2 papers)

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Review

27 pages, 872 KiB  
Review
Primary Psychosis: Risk and Protective Factors and Early Detection of the Onset
by Claudio Brasso, Benedetta Giordano, Cristina Badino, Silvio Bellino, Paola Bozzatello, Cristiana Montemagni and Paola Rocca
Diagnostics 2021, 11(11), 2146; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112146 - 19 Nov 2021
Cited by 12 | Viewed by 4661
Abstract
Primary psychosis, which includes schizophrenia and other psychoses not caused by other psychic or physical conditions, has a strong impact worldwide in terms of disability, suffering and costs. Consequently, improvement of strategies to reduce the incidence and to improve the prognosis of this [...] Read more.
Primary psychosis, which includes schizophrenia and other psychoses not caused by other psychic or physical conditions, has a strong impact worldwide in terms of disability, suffering and costs. Consequently, improvement of strategies to reduce the incidence and to improve the prognosis of this disorder is a current need. The purpose of this work is to review the current scientific literature on the main risk and protective factors of primary psychosis and to examine the main models of prevention, especially those related to the early detection of the onset. The conditions more strongly associated with primary psychosis are socio-demographic and economic factors such as male gender, birth in winter, ethnic minority, immigrant status, and difficult socio-economic conditions while the best-established preventive factors are elevated socio-economic status and an economic well-being. Risk and protective factors may be the targets for primordial, primary, and secondary preventive strategies. Acting on modifiable factors may reduce the incidence of the disorder or postpone its onset, while an early detection of the new cases enables a prompt treatment and a consequential better prognosis. According to this evidence, the study of the determinants of primary psychosis has a pivotal role in designing and promoting preventive policies aimed at reducing the burden of disability and suffering of the disorder. Full article
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36 pages, 823 KiB  
Review
Borderline Personality Disorder: Risk Factors and Early Detection
by Paola Bozzatello, Claudia Garbarini, Paola Rocca and Silvio Bellino
Diagnostics 2021, 11(11), 2142; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11112142 - 18 Nov 2021
Cited by 21 | Viewed by 32836
Abstract
Personality disorders (PDs) exert a great toll on health resources, and this is especially true for borderline personality disorder (BPD). As all PDs, BPD arises during adolescence or young adulthood. It is therefore important to detect the presence of this PD in its [...] Read more.
Personality disorders (PDs) exert a great toll on health resources, and this is especially true for borderline personality disorder (BPD). As all PDs, BPD arises during adolescence or young adulthood. It is therefore important to detect the presence of this PD in its earlier stages in order to initiate appropriate treatment, thus ameliorating the prognosis of this condition. This review aims to highlight the issues associated with BPD diagnosis in order to promote its early detection and treatment. To do so, we conducted a search on PubMed database of current evidence regarding BPD early diagnosis, focusing on risk factors, which represent important conditions to assess during young patient evaluation, and on diagnostic tools that can help the clinician in the assessment process. Our findings show how several risk factors, both environmental and genetic/neurobiological, can contribute to the onset of BPD and help identify at-risk patients who need careful monitoring. They also highlight the importance of a careful clinical evaluation aided by psychometric tests. Overall, the evidence gathered confirms the complexity of BDP early detection and its crucial importance for the outcome of this condition. Full article
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