Dry Eye and Ocular Surface Disorders 2.0

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 2805

Special Issue Editors


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Guest Editor
1. Department of Ophthalmology, Keio University School of Medicine, Shi-nanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan
2. Visiting Senior Fellow, UNSW School of Optometry and Vision Science, Sydney, NSW 2052, Australia
Interests: dry eye; oxidative stress; diagnostic imaging; biomarkers; ocular allergy; contact lens
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Special Issue Information

Dear Colleagues,

In recent years, dry eye has been widely investigated in many studies including epidemiological, basic and clinical study, and recent achievements are remarkable. Dry eye is a disease in which the tear film stability decreases. The mechanism is associated with inflammation, friction with eyelids, changes in tear osmolarity, amount of tear secretion, wettability of ocular surface, tear evaporation etc., which are involved in a complex way to form a pathological condition. In addition, in dry eye disease, it has been pointed out that the difference between subjective symptoms and ocular findings. Recently, research has been conducted in several aspects including involvement of the nervous system, and it has become clear that dry eye also contains elements of neuropathic pain. With regard to treatment, treatments targeting tear stability, inflammation and friction are being performed. Moreover, in recent years, secretagogue of water and mucin components has been widely used in Asian countries. However, understanding of dry eye pathology, diagnosis and treatment is still inadequate. New insights and breakthroughs will be needed to overcome these problems in the future. In this special issue, we are looking for research results including new findings in the fields of ocular surface and dry eye disease. The aim is to broaden the direction and possibilities of dry eye research. We are looking forward to and will be welcoming your invaluable work in this issue.

You may choose our Joint Special Issue in International Journal of Molecular Sciences.

Dr. Murat Dogru
Prof. Dr. Takashi Kojima
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Dry eye
  • basic research
  • clinical research
  • treatment
  • animal model
  • neuropathic pain
  • ocular surface
  • pathophysiology
  • diagnosis

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Published Papers (1 paper)

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Research

8 pages, 2833 KiB  
Article
Tear ATG5 as a Potential Novel Biomarker in the Diagnosis of Sjögren Syndrome
by Yong-Soo Byun, Hyun Jung Lee, Soojung Shin, Moon Young Choi, Hyung-Seung Kim and So-Hyang Chung
Diagnostics 2021, 11(1), 71; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11010071 - 04 Jan 2021
Cited by 8 | Viewed by 1997
Abstract
Autophagy has been suggested to have an important role in the pathogenesis of Sjögren syndrome (SS). We previously identified that autophagy related 5 (ATG5) was elevated in the tear and conjunctival epithelial cells of SS dry eyes (DE) compared to non-SS DE. The [...] Read more.
Autophagy has been suggested to have an important role in the pathogenesis of Sjögren syndrome (SS). We previously identified that autophagy related 5 (ATG5) was elevated in the tear and conjunctival epithelial cells of SS dry eyes (DE) compared to non-SS DE. The purpose of this study was to investigate the role of tear ATG5 as a potential biomarker in the diagnosis of SS. To confirm this hypothesis, we evaluated the tear ATG5 concentration, and other ocular tests (Schirmer I, tear breakup time (TBUT), ocular surface staining (OSS) score, ocular surface disease index (OSDI)) in SS and non-DE, and compared their diagnostic performance to discriminate SS from non-SS DE. Tear ATG5 showed the greatest area under the curve (AUC = 0.984; 95% CI, 0.930 to 0.999) among the tests, and a 94.6% sensitivity and 93.6% specificity at a cutoff value of >4.0 ng/mL/μg. Our data demonstrated that tear ATG5 may be helpful as an ocular biomarker to diagnose and assess SS. In the future, the diagnostic power of tear ATG for SS should be validated. Full article
(This article belongs to the Special Issue Dry Eye and Ocular Surface Disorders 2.0)
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