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Diagnostics
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Usefulness of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cancer
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Usefulness of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4728

Special Issue Editor

Dr. Takashi Tamura

E-Mail Website
Guest Editor
Department of Internal Medicine 2, Wakayama Medical University, 811-1 Kimiidera, Wakayama 6410012, Japan
Interests: endoscopic ultrasound; pancreatic disease; biliary disease; submucosal tumor

Special Issue Information

Dear Colleagues,

Endoscopic ultrasonography (EUS) is thought to be one of the most useful modalities for the diagnosis of pancreatic diseases because its spatial resolution is superior to any other modality. However, EUS is inferior to other modalities in terms of hemodynamic assessment. Contrast-enhanced harmonic EUS (CH-EUS) allows for vascular assessment of pancreatic lesions thanks to the advent of the second generation of ultrasound contrast agents. There are many reports on the usefulness of CH-EUS in the diagnostic field. In particular, CH-EUS is reported to be useful for the diagnosis of pancreatic cancer due to its capacity to differentiate between tumor types with high sensitivity based on differences in contrast effects. CH-EUS is also reportedly useful for staging of pancreatic cancer. Recently, CH-EUS has not only been used for diagnosis, but its usefulness in performing EUS-FNA for pancreatic cancer has also been reported. In addition, CH-EUS is reported to be useful for evaluating chemotherapy for pancreatic cancer. Therefore, CH-EUS is currently used not only in diagnosis but also in various fields of treatment of pancreatic cancer. The aim of this Special Issue is to collect new data and evidence on the usefulness of CH-EUS for pancreatic cancer.

Dr. Takashi Tamura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Pancreatic cancer
  • Pancreatic tumor
  • Contrast-enhanced harmonic endoscopic ultrasound
  • EUS-FNA
  • Chemotherapy

Published Papers (2 papers)

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Review

10 pages, 9832 KiB  
Review
Contrast-Enhanced Harmonic Endoscopic Ultrasound-Guided Puncture for the Patients with Pancreatic Masses
by Yasuo Otsuka, Ken Kamata and Masatoshi Kudo
Diagnostics 2023, 13(6), 1039; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics13061039 - 08 Mar 2023
Cited by 2 | Viewed by 1651
Abstract
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful for the diagnosis of pancreatic masses. According to three meta-analyses, the sensitivity, specificity, and accuracy of EUS-FNA are 84–92%, 96–98%, and 86–91%, respectively. However, the occurrence of false-negative and false-positive results indicates that the diagnostic performance [...] Read more.
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is useful for the diagnosis of pancreatic masses. According to three meta-analyses, the sensitivity, specificity, and accuracy of EUS-FNA are 84–92%, 96–98%, and 86–91%, respectively. However, the occurrence of false-negative and false-positive results indicates that the diagnostic performance of EUS-FNA needs to be improved. Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is used for the characterization of pancreatic masses and can be applied to improve the performance of EUS-FNA. When CH-EUS is used to evaluate intratumor blood flow, an avascular area inside the pancreatic mass that is considered to be fibrosis is often detected. This area can be avoided by performing EUS-FNA under CH-EUS guidance. In this review, we summarize the data on contrast-enhanced harmonic endoscopic ultrasound-guided fine-needle aspiration (CH-EUS-FNA), which suggest that its benefit is still a matter of debate. Of eight studies analyzed, only one showed that CH-EUS improved the sensitivity of EUS-FNA. The future challenge is to determine under what circumstances CH-EUS-FNA is useful. Full article
(This article belongs to the Special Issue Usefulness of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cancer)
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9 pages, 2771 KiB  
Review
Efficacy of Contrast-Enhanced Endoscopic Ultrasonography for the Diagnosis of Pancreatic Tumors
by Kensuke Yokoyama, Atsushi Kanno, Tetsurou Miwata, Hiroki Nagai, Eriko Ikeda, Kozue Ando, Yuki Kawasaki, Kiichi Tamada, Alan Kawarai Lefor and Hironori Yamamoto
Diagnostics 2022, 12(6), 1311; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12061311 - 25 May 2022
Viewed by 1643
Abstract
Endoscopic ultrasound can be useful for obtaining detailed diagnostic images for pancreatic disease. Contrast-enhanced harmonic endoscopic ultrasound has allowed to demonstrate not only microvasculature but also real perfusion imaging using second-generation contrast agents. Furthermore, endoscopic ultrasound fine-needle aspiration cytology and histology have become [...] Read more.
Endoscopic ultrasound can be useful for obtaining detailed diagnostic images for pancreatic disease. Contrast-enhanced harmonic endoscopic ultrasound has allowed to demonstrate not only microvasculature but also real perfusion imaging using second-generation contrast agents. Furthermore, endoscopic ultrasound fine-needle aspiration cytology and histology have become more ubiquitous; however, the risk of dissemination caused by paracentesis has yet to be resolved, and the application of less invasive contrast-enhanced endoscopic ultrasound for the differential diagnosis of pancreatic tumors has been anticipated. Contrast-enhanced harmonic endoscopic ultrasound can contribute to the differential diagnosis of pancreatic tumors. Full article
(This article belongs to the Special Issue Usefulness of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cancer)
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