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Diagnostics
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Advances in the Diagnosis of Lung Nodules
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Advances in the Diagnosis of Lung Nodules

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3913

Special Issue Editor

Dr. Wonjun Ji

E-Mail Website
Guest Editor
Department of Pulmonary and Critical Care Medicine, Asan Medical Center 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Interests: diagnostic bronchoscopy; interventional pulmonology; lung cancer; lung cancer screening; lung nodules; biomarkers for lung nodule and lung cancer

Special Issue Information

Dear Colleagues,

Since the effectiveness of lung cancer screening using low-dose chest computed tomography (LDCT) has been well-established, many studies have been conducted to diagnose lung nodules found through screening. In particular, not only transthoracic needle biopsy (TTNB), but also new diagnostic techniques including electromagnetic navigation bronchoscopy (ENB), radial probe endobronchial ultrasound (rEBUS), ultrathin bronchoscopy, and robotic bronchoscopy have been developed and utilized recently for accurate histological diagnosis. In addition, liquid biopsy using many kinds of specimens from the human body and various biomarkers have been reported for the differential diagnosis of lung nodules.

For this reason, research on advanced diagnostic methods for lung nodules is paramount and highlighted more than ever in the era of lung cancer screening using LDCT. Hence, all research regarding advances in the diagnosis of lung nodules are welcome in this Special Issue. We warmly invite you and your colleagues to submit any types of articles—original research articles, comprehensive and critical reviews, and even letters—given the expansive interest of this area.

Dr. Wonjun Ji
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung nodule
  • transthoracic needle biopsy (TTNB)
  • diagnostic bronchoscopy
  • biomarker
  • liquid biopsy

Published Papers (2 papers)

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Research

14 pages, 996 KiB  
Article
C-Arm Cone-Beam CT Virtual Navigation versus Conventional CT Guidance in the Transthoracic Lung Biopsy: A Case-Control Study
by Lian Yang, Yue Wang, Lin Li, Dehan Liu, Xin Wu, Wei Zhang, Feng Pan, Huimin Liang and Chuansheng Zheng
Diagnostics 2022, 12(1), 115; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12010115 - 05 Jan 2022
Cited by 6 | Viewed by 2012
Abstract
C-arm cone-beam computed tomography (CBCT) virtual navigation-guided lung biopsy has been developed in the last decade as an alternative to conventional CT-guided lung biopsy. This study aims to compare the biopsy accuracy and safety between these two techniques and explores the risk factors [...] Read more.
C-arm cone-beam computed tomography (CBCT) virtual navigation-guided lung biopsy has been developed in the last decade as an alternative to conventional CT-guided lung biopsy. This study aims to compare the biopsy accuracy and safety between these two techniques and explores the risk factors of biopsy-related complications. A total of 217 consecutive patients undergoing conventional CT- or C-arm CBCT virtual navigation-guided lung biopsy from 1 June 2018 to 31 December 2019 in this single-center were retrospectively reviewed. Multiple factors (e.g., prior emphysema, lesion size, etc.) were compared between two biopsy techniques. The risk factors of complications were explored by using logistic regression. The patients’ median age and male-to-female ratio were 63 years and 2.1:1, respectively. Eighty-two (82) patients (37.8%) underwent conventional CT-guided biopsies, and the other 135 patients (62.2%) C-arm CBCT virtual navigation-guided biopsies. Compared with patients undergoing C-arm CBCT virtual navigation-guided lung biopsies, patients undergoing conventional CT-guided lung biopsies showed higher needle repositioning rate, longer operation time, and higher effective dose of X-ray (52.4% vs. 6.7%, 25 min vs. 15 min, and 13.4 mSv vs. 7.6 mSv, respectively; p < 0.001, each). In total, the accurate biopsy was achieved in 215 of 217 patients (99.1%), without a significant difference between the two biopsy techniques (p = 1.000). The overall complication rates, including pneumothorax and pulmonary hemorrhage/hemoptysis, are 26.3% (57/217), with most minor complications (56/57, 98.2%). The needle repositioning was the only independent risk factor of complications with an odds ratio of 6.169 (p < 0.001). In conclusion, the C-arm CBCT virtual navigation is better in percutaneous lung biopsy than conventional CT guidance, facilitating needle positioning and reducing radiation exposure. Needle repositioning should be avoided because it brings about more biopsy-related complications. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Lung Nodules)
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8 pages, 802 KiB  
Article
A Pilot Study of Transbronchial Biopsy Using Endobronchial Ultrasonography with a Guide Sheath in the Diagnosis of Peripheral Pulmonary Lesions in Patients with Interstitial Lung Disease
by Takayasu Ito, Tomoki Kimura, Kensuke Kataoka, Shotaro Okachi, Keiko Wakahara, Naozumi Hashimoto and Yasuhiro Kondoh
Diagnostics 2021, 11(12), 2269; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11122269 - 04 Dec 2021
Cited by 5 | Viewed by 1321
Abstract
The occurrence of interstitial lung disease (ILD) with peripheral pulmonary lesions (PPLs) is closely linked to the development of lung cancer. Yet, the best diagnostic approach for identifying PPLs in patients with ILD remains elusive. This study retrospectively investigated the application of transbronchial [...] Read more.
The occurrence of interstitial lung disease (ILD) with peripheral pulmonary lesions (PPLs) is closely linked to the development of lung cancer. Yet, the best diagnostic approach for identifying PPLs in patients with ILD remains elusive. This study retrospectively investigated the application of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) to the effective and safe diagnosis of PPLs when compared with conventional TBB. The study sample included a consecutive series of 19 patients with ILD who underwent conventional TBB or TBB using EBUS-GS at Tosei General Hospital between 1 April 2013 and 31 October 2015. The two techniques were compared based on diagnostic yield and associated complications. The diagnostic yield of EBUS-GS TBB was significantly higher than that of conventional TBB (p = 0.009), especially for small lesions (≤20 mm), lesions located in the lower lobes, lesions with a positive bronchus sign, and lesions visible by chest radiography (p = 0.010, p = 0.022, p = 0.006, and p = 0.002, respectively). There were no significant differences in complication rates. Therefore, EBUS-GS is an effective alternative for the diagnosis of PPLs in patients with ILD, without additional complications. Full article
(This article belongs to the Special Issue Advances in the Diagnosis of Lung Nodules)
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