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Diagnostics
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Positron Emission Tomography (PET) Imaging for Therapy Monitoring
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Positron Emission Tomography (PET) Imaging for Therapy Monitoring

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 38660

Special Issue Editors

Dr. Silvia Morbelli

E-Mail Website
Guest Editor
1. Nuclear Medicine Unit, Department of Health Science, University of Genova, 16132 Genoa, Italy
2. IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Interests: imaging biomarkers; brain PET and SPECT; neurodegenerative diseases; molecular imaging in oncology; lymphomas; theragnostic
Special Issues, Collections and Topics in MDPI journals
Dr. Matteo Bauckneht

E-Mail Website
Guest Editor
Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
Interests: imaging biomarkers; positron emission tomography; nuclear neurology; prostate cancer; nuclear cardiology; theranostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The effectiveness of cancer treatment must be assessed early in the course of therapy so that regimens can be tailored on a single-patient basis. There is an increasing need to identify imaging tools that can be used as surrogate biomarkers especially for a response to novel therapies in oncology. Response to therapy in cancer is conventionally monitored by means of morphological imaging. Traditionally, a shrinkage in tumor burden indicates treatment success and if not seen, patients are assumed to be non-responders. However, while patients who respond to treatment are known to have a better prognosis, the validity of objective response to chemotherapy as a surrogate endpoint of survival is more contradictory, especially, in some clinical settings. In recent years, the problem became even more pronounced with the introduction of novel anticancer targeted therapies, and for all regimens with immune checkpoints inhibitors (ICI). Accordingly, besides morphologic criteria, response criteria based on functional imaging such as PERCIST, Deauville Criteria, or Immuno-therapy modified criteria based on PET evaluation have been proposed and are in the course of their validation in oncological clinical settings. Furthermore, in recent years, functional imaging and molecular imaging modalities have been identified as possible tools for the early identification of systemic treatment-related toxicity. The growing evidence available for response evaluation through functional imaging in oncology is further pushing the definition of imaging-based criteria in other clinical settings such as response to inflammatory or infectious disease. In fact, therapy monitoring of infections can be extremely challenging and controversies still persist regarding reliable biomarkers for noninvasive response evaluation. Indeed, there are currently no clinical criteria or recommended imaging modalities to objectively evaluate the effectiveness of antimicrobial treatment. The aim of this Special Issue of Diagnostics is to summarize recent data describing the use of functional and molecular imaging strategies for response assessment and to offer guidance related to use of objective imaging-based criteria in patients treated for oncological or infectious diseases. Articles related to the identification of systemic treatment-related side effects by means of functional and molecular imaging tools will be also included.

Dr. Silvia Morbelli
Dr. Matteo Bauckneht
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molecular imaging for therapy monitoring
  • Imaging response criteria
  • Positron emission tomography (PET)
  • PERCIST
  • Imaging of infections
  • Cancer imaging
  • Functional imaging of treatment-related side effects

Published Papers (12 papers)

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Research

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11 pages, 1792 KiB  
Article
Diagnostic Performance of F18-FDG PET/CT in Male Breast Cancers Patients
by Andra Piciu, Doina Piciu, Narcis Polocoser, Anita A. Kovendi, Iulia Almasan, Alexandru Mester, Dragos-Stefan Morariu, Calin Cainap and Simona Sorana Cainap
Diagnostics 2021, 11(1), 119; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11010119 - 13 Jan 2021
Cited by 6 | Viewed by 4787
Abstract
Introduction: F18-FDG PET/CT is the most important hybrid imaging used in the diagnostic, staging, follow-up, and treatment evaluation response in cancer patients. However, it is well-known that in breast cancer the use of F18-FDG is not included in the first line protocol of [...] Read more.
Introduction: F18-FDG PET/CT is the most important hybrid imaging used in the diagnostic, staging, follow-up, and treatment evaluation response in cancer patients. However, it is well-known that in breast cancer the use of F18-FDG is not included in the first line protocol of initial diagnostic, both in female and male breast cancer patients. F18-FDG PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases, and other occult primary cancers. This study assesses F18-FDG PET/CT systemic staging in male patients with diagnosed breast cancer and determines detection rates for unsuspected distant metastases and synchronous malignancies. Methods: We analyzed a number of 170 male patients with breast cancer, seen between 2000–2020, in a tertiary center. From this group, between 2013–2020 a number of 23 patients underwent F18-FDG PET/CT. Rates of upstaging were determined for each case and the detection of other primary malignancies was analyzed. Results: Median age of male breast cancer group was 61.3 y (range, 34–85 y), most had intraductal carcinoma (82.4%) and unsuspected distant metastases, which increased patient stage to IV, observed in 27%. In 4 out 23 patients (17.4%), F18-FDG PET/CT identified synchronous cancers (2 prostate cancers, 1 thyroid and 1 colon cancer). Conclusion: F18-FDG PET/CT is a valuable tool to provide information on extra-axillary lymph node involvement, distant metastases, and other occult primary cancers. Baseline F18-FDG PET/CT has a substantial impact on the initial staging and on clinical management in male breast patients and should be considered for use in newly diagnosed patients. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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12 pages, 2838 KiB  
Article
Early Interim Chemotherapy Response Evaluation by F-18 FDG PET/CT in Diffuse Large B Cell Lymphoma
by Hye Lim Park, Eun Ji Han, Joo Hyun O, Byung-Ock Choi, Gyeongsin Park, Seung-Eun Jung, Seung-Ah Yahng, Ki-Seong Eom, Seok-Goo Cho and on behalf of Catholic University Lymphoma Group
Diagnostics 2020, 10(12), 1002; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10121002 - 24 Nov 2020
Cited by 2 | Viewed by 2002
Abstract
Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) after one cycle of standard chemotherapy in patients with diffuse large B cell lymphoma (DLBCL) was assessed. Prospectively enrolled 51 patients had four PET/CT studies using the same protocol and system: at baseline and [...] Read more.
Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) after one cycle of standard chemotherapy in patients with diffuse large B cell lymphoma (DLBCL) was assessed. Prospectively enrolled 51 patients had four PET/CT studies using the same protocol and system: at baseline and after one, three, and six cycles of chemotherapy (PET0, PET1, PET3, PET6). The PET1 and PET6 Deauville five-point score (D5PS) agreed in 60.8%, while PET3 and PET6 D5PS agreed in 90.2%. The absolute and percent changes of peak standard uptake value corrected for lean body mass (SULpeak) compared to baseline were significantly different between PET1 and PET3 (p = 0.001, p < 0.001) and PET1 and PET6 (p = 0.002, p = 0.001), but not between PET3 and PET6 (p = 0.276, p = 0.181). The absolute SULpeak from PET1 predicted treatment failure with accuracy of 78.4% (area under the curve 0.73, p = 0.023). D5PS, SULpeak, and metabolic tumor volume (MTV) were not statistically different between responders versus non-responders, or the one year disease-free versus relapse groups. D5PS and PERCIST responses showed 100% agreement at end-of-therapy. In conclusion, the responses after three and six cycles of therapy showed high degree of agreement. D5PS or MTV after one cycle of chemotherapy could not predict response or one-year disease-free status, but the SULpeak from PET1 was associated with response to first line therapy in DLBCL. Deauville and PERCIST criteria show high concordance. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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12 pages, 558 KiB  
Article
Assessment of Therapeutic Response in Pyogenic Vertebral Osteomyelitis Using 18F-FDG-PET/MRI
by Ikchan Jeon, Eunjung Kong, Sang Woo Kim, Ihn Ho Cho and Cheol Pyo Hong
Diagnostics 2020, 10(11), 916; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10110916 - 08 Nov 2020
Cited by 9 | Viewed by 1735
Abstract
Purpose: There is still no definite method to determine therapeutic response in pyogenic vertebral osteomyelitis (PVO). We analyzed the value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for assessing therapeutic response in PVO. Methods: This retrospective study included 53 patients (32 men and [...] Read more.
Purpose: There is still no definite method to determine therapeutic response in pyogenic vertebral osteomyelitis (PVO). We analyzed the value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for assessing therapeutic response in PVO. Methods: This retrospective study included 53 patients (32 men and 21 women) with lumbar PVO. The results of clinical assessments for therapeutic response were divided into “Cured” (group C) and “Non-cured” (group NC). The differences in clinical and radiological features of PVO lesions between the two groups were analyzed using clinical data and simultaneous FDG-PET/magnetic resonance imaging (MRI) obtained at each clinical assessment. Results: Clinical assessments and FDG-PET/MRIs were performed at 41.89 ± 16.08 (21–91) days of parenteral antibiotic therapy. There were 39 patients in group C and 14 in group NC. Diagnostic accuracies (DAs) of FDG uptake intensity-based interpretation and C-reactive protein (CRP) for residual PVO were as follows (p < 0.01): 84.9% of the maximum standardized uptake value of PVO lesion (PvoSUVmax), 86.8% of ΔPvoSUVmax−NmlSUVmax (SUVmax of normal vertebra), 86.8% of ΔPvoSUVmax−NmlSUVmean (SUVmean of normal vertebra), and 71.7% of CRP. DAs were better (92.5–94.3%) when applying FDG uptake intensity-based interpretation and CRP together. Under the FDG uptake distribution-based interpretation, FDG uptake was significantly limited to intervertebral structures in group C (p = 0.026). Conclusion: The interpretations of intensity and distribution of FDG uptake on FDG-PET are useful for detecting residual PVO in the assessment of therapeutic response of PVO. The combination of FDG-PET and CRP is expected to increase DA for detecting residual PVO. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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10 pages, 366 KiB  
Article
Does Routine Triple-Time-Point FDG PET/CT Imaging Improve the Detection of Liver Metastases?
by Yu-An Yen, Wen-Sheng Huang, Chuang-Hsin Chiu, Yu-Chang Tyan, Jhi-Joung Wang, Li-Chun Wu, I Jung Feng and Chiang Hsuan Lee
Diagnostics 2020, 10(9), 609; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10090609 - 19 Aug 2020
Cited by 2 | Viewed by 2693
Abstract
Prior reports have demonstrated the improved ability of delayed fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging (dual-time-point imaging) in detecting more patients with liver metastases. To evaluate whether routine triple-time-point FDG PET/CT imaging improves the detection of liver [...] Read more.
Prior reports have demonstrated the improved ability of delayed fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging (dual-time-point imaging) in detecting more patients with liver metastases. To evaluate whether routine triple-time-point FDG PET/CT imaging improves the detection of liver metastasis not visualized on initial imaging. To our knowledge, no triple-time-point imaging has been reported. This retrospective study included total 310 patients with various malignancies who underwent PET/CT scans. Triple-time-point imaging including the liver was obtained. The comparison between negative and positive liver lesions on delayed imaging for patients with initial negative imaging were analyzed. Of the 310 patients, 286 did not exhibit liver lesions on initial imaging, but six of the 286 patients exhibited lesions on delayed imaging. No additional liver lesions were detected on further delayed imaging in the 286 patients. The other 24 patients with liver lesions identified on initial imaging still showed lesions on delayed and further delayed imaging. The analysis showed a significant difference in the percentage of colorectal cancer (66.7%) and liver lesions before the PET scan (50.0%) compared with unchanged results (22.1% and 3.9%, respectively). Routine triple-time-point imaging did not improve the detection of liver metastases; however, it may be recommended in patients with colorectal cancer and liver lesions before the PET scan. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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9 pages, 453 KiB  
Article
Fusion and Healing Prediction in Posterolateral Spinal Fusion Using 18F-Sodium Fluoride-PET/CT
by Caius M. Constantinescu, Michael K. Jacobsen, Oke Gerke, Mikkel Ø. Andersen and Poul F. Høilund-Carlsen
Diagnostics 2020, 10(4), 226; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10040226 - 16 Apr 2020
Cited by 2 | Viewed by 3244
Abstract
This study measures the total graft of 18F-sodium fluoride (NaF) uptake in non-instrumented posterolateral lumbar fusion (niPLF) patients one month after surgery and correlates it with the difference in the clinical findings between the baseline and one year after surgery. The walking [...] Read more.
This study measures the total graft of 18F-sodium fluoride (NaF) uptake in non-instrumented posterolateral lumbar fusion (niPLF) patients one month after surgery and correlates it with the difference in the clinical findings between the baseline and one year after surgery. The walking distance (WLK-D), visual analog scale of back pain (VAS-B), VAS score of leg pain (VAS-L), tandem test (TAN), Oswestry Disability Index questionnaire (ODI), and European Quality of Life-5 Dimensions questionnaire (EQ-5D) were assessed before surgery and one year after. The graft NaF uptake was analyzed quantitatively with a fixed threshold algorithm resulting in the total graft uptake (SUVtotal) and partial volume corrected SUVtotal (cSUVtotal). Only 4 out of 18 patients experienced fusion; they had an insignificantly lower median total graft uptakes, i.e., 1178 SUVtotal vs. 1224 SUVtotal (p = 0.73) and 1282 cSUVtotal vs. 1231 cSUVtotal (p = 0.35), respectively. Similarly, fused patients experienced insignificantly larger pain decreases, i.e., median VAS-B 4.3 vs. 3.8 (p = 0.92) and VAS-L −6.4 vs. −4.4 (p = 0.2). We found an insignificant trend for a lower NaF uptake and less pain in fused patients. The NaF uptake did not correlate with the chronological change in the clinical parameters. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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Review

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18 pages, 1054 KiB  
Review
Positron Emission Tomography (PET) Imaging of Multiple Myeloma in a Post-Treatment Setting
by Giulia Ferrarazzo, Silvia Chiola, Selene Capitanio, Maria Isabella Donegani, Alberto Miceli, Stefano Raffa, Alberto Stefano Tagliafico, Silvia Morbelli and Matteo Bauckneht
Diagnostics 2021, 11(2), 230; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11020230 - 03 Feb 2021
Cited by 2 | Viewed by 1973
Abstract
2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM). In the last ten years, a vast body of literature has shown that this tool can also be of high [...] Read more.
2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM). In the last ten years, a vast body of literature has shown that this tool can also be of high relevance for monitoring therapy responses, making it the recommended imaging approach in this field. Starting from the strengths and weaknesses of radiological imaging in MM, the present review aims to analyze FDG PET/CT’s current clinical value focusing on therapy response assessment and objective interpretation criteria for therapy monitoring. Given the potential occurrence of patients with MM showing non-FDG-avid bone disease, new opportunities can be provided by non-FDG PET tracers. Accordingly, the potential role of non-FDG PET tracers in this setting has also been discussed. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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24 pages, 1356 KiB  
Review
Prognostic Value of 18F–FDG–PET Parameters in Patients with Small Cell Lung Cancer: A Meta-Analysis and Review of Current Literature
by Tine Nøhr Christensen, Per Kragh Andersen, Seppo W. Langer and Barbara Malene Bjerregaard Fischer
Diagnostics 2021, 11(2), 174; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11020174 - 26 Jan 2021
Cited by 10 | Viewed by 2887
Abstract
Many studies have suggested a prognostic value of one or several positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC). However, studies are often small, and there is a considerable interstudy disagreement about which PET parameters have a prognostic [...] Read more.
Many studies have suggested a prognostic value of one or several positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC). However, studies are often small, and there is a considerable interstudy disagreement about which PET parameters have a prognostic value. The objective of this study was to perform a review and meta-analysis to identify the most promising PET parameter for prognostication. PubMed®, Cochrane, and Embase® were searched for papers addressing the prognostic value of any PET parameter at any treatment phase with any endpoint in patients with SCLC. Pooled hazard ratios (HRs) were calculated by a random effects model for the prognostic value of the baseline maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV). The qualitative analysis included 38 studies, of these, 19 studies were included in the meta-analyses. The pooled results showed that high baseline MTV was prognostic for overall survival (OS) (HR: 2.83 (95% confidence interval [CI]: 2.00–4.01) and progression-free survival (PFS) (HR: 3.11 (95% CI: 1.99–4.90)). The prognostic value of SUVmax was less pronounced (OS: HR: 1.50 (95% CI: 1.17–1.91); PFS: HR: 1.24 (95% CI: 0.94–1.63)). Baseline MTV is a strong prognosticator for OS and PFS in patients with SCLC. MTV has a prognostic value superior to those of other PET parameters, but whether MTV is superior to other prognosticators of tumor burden needs further investigation. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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31 pages, 1857 KiB  
Review
The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future
by Virginia Liberini, Martin W. Huellner, Serena Grimaldi, Monica Finessi, Philippe Thuillier, Alfredo Muni, Riccardo E. Pellerito, Mauro G. Papotti, Alessandro Piovesan, Emanuela Arvat and Désirée Deandreis
Diagnostics 2020, 10(12), 1083; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10121083 - 12 Dec 2020
Cited by 26 | Viewed by 5817
Abstract
The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT response assessment is challenging and no consensus on methods and timing [...] Read more.
The NETTER-1 study has proven peptide receptor radionuclide therapy (PRRT) to be one of the most effective therapeutic options for metastatic neuroendocrine tumors (NETs), improving progression-free survival and overall survival. However, PRRT response assessment is challenging and no consensus on methods and timing has yet been reached among experts in the field. This issue is owed to the suboptimal sensitivity and specificity of clinical biomarkers, limitations of morphological response criteria in slowly growing tumors and necrotic changes after therapy, a lack of standardized parameters and timing of functional imaging and the heterogeneity of PRRT protocols in the literature. The aim of this article is to review the most relevant current approaches for PRRT efficacy prediction and response assessment criteria in order to provide an overview of suitable tools for safe and efficacious PRRT. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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Other

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6 pages, 1484 KiB  
Interesting Images
Usefulness of 18f-FDG PET-CT in Staging, Restaging, and Response Assessment in Pediatric Rhabdomyosarcoma
by Davide Donner, Paola Feraco, Linda Meneghello, Barbara Rombi, Lorena Picori and Franca Chierichetti
Diagnostics 2020, 10(12), 1112; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10121112 - 21 Dec 2020
Cited by 2 | Viewed by 2381
Abstract
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Despite clinical advances, subsets of these patients continue to suffer high morbidity and mortality rates associated with their disease. Following the European guidelines for 18F-FDG PET and PET-CT imaging in pediatric oncology, the [...] Read more.
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Despite clinical advances, subsets of these patients continue to suffer high morbidity and mortality rates associated with their disease. Following the European guidelines for 18F-FDG PET and PET-CT imaging in pediatric oncology, the routine use of 18F-FDG PET-CT may be useful for patients affected by rhabdomyosarcoma, in staging, in the evaluation of response to therapy, and for restaging/detection of relapse. The European Pediatric Protocols are very old, and for staging and restaging, they recommend only radionuclide bone scan. The 18F-FDG PET-CT exam is listed as an optional investigation prescribed according to local availability and local protocols in the investigations panel required at the end of the treatment. We present two cases highlighting the usefulness of 18F-FDG PET-CT in managing pediatric patients affected by rhabdomyosarcoma, providing some bibliographic references. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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5 pages, 1186 KiB  
Case Report
Right Atrium Mass Assessed with 18F-FDG PET/CT Scan Turns Out to Be an Uncommon Relapse of Testicular Diffuse Large B-cell Lymphoma: A Case Report
by Stefano Panareo, Luca Urso, Ivan Santi, Gian Matteo Rigolin, Antonio Cuneo, Corrado Cittanti and Mirco Bartolomei
Diagnostics 2020, 10(11), 987; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10110987 - 23 Nov 2020
Cited by 4 | Viewed by 2357
Abstract
We report the case of a 71-year-old man affected by testicular large B-cell lymphoma (DLBCL), treated with right orchiectomy and first-line chemotherapy (R-CHOP, 8 cycles). A complete remission was obtained after therapy. Twenty-two months after the primary diagnosis the patient suddenly presented dyspnoea [...] Read more.
We report the case of a 71-year-old man affected by testicular large B-cell lymphoma (DLBCL), treated with right orchiectomy and first-line chemotherapy (R-CHOP, 8 cycles). A complete remission was obtained after therapy. Twenty-two months after the primary diagnosis the patient suddenly presented dyspnoea and superior vena cava syndrome; thus, he underwent a CT scan that revealed a large mass in the right atrium, expanding to the superior vena cava. A differential diagnosis between a neoplastic mass and a clot was proposed. The subsequent MR did not clarify the nature of the mass; therefore, the patient underwent an 18F-FDG PET/CT scan (PET/CT), after a specific preparation to reduce fluoro-deoxyglucose (FDG) myocardial uptake. PET/CT revealed an intense FDG uptake involving the whole mass (SUVmax 9.4), suggestive for neoplasm and confirmed by the subsequent endocardiac biopsy. The patient was treated with 8 cycles of R-COMP, obtaining a complete remission, as indicated by the PET/CT performed after the seventh cycle of therapy. The case that we are reporting highlights that DLBCL can have an uncommon relapse presentation in the atrium. PET/CT, compared to conventional imaging, can be a valuable tool to detect early and better characterize cardiac lesions in order to improve the poor prognosis of these conditions. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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3 pages, 443 KiB  
Interesting Images
Spontaneous Remission and Concomitant Progression in a Patient with DLBCL
by Eun Ji Han, Jihyun Kim, Suk Young Park and Joo Hyun O
Diagnostics 2020, 10(11), 950; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10110950 - 14 Nov 2020
Cited by 1 | Viewed by 2058
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Although DLBCL can be cured in more than half of all patients, up to 50% of patients become refractory to initial treatment or relapse after complete remission. We present a case [...] Read more.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Although DLBCL can be cured in more than half of all patients, up to 50% of patients become refractory to initial treatment or relapse after complete remission. We present a case of complete spontaneous remission of some tumors and concomitant newly developed tumors observed in a patient with relapsed DLBCL. Spontaneous remission of lymphoma without treatment is a rare phenomenon and can occur at baseline as well as in relapsed DLBCL. However, most patients who initially experience spontaneous remission later develop relapse. Thus, careful follow-up is required, and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) allows monitoring of multiple lesions. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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9 pages, 4813 KiB  
Case Report
Left Supraclavicular Lymph Node Metastasis from Ovarian Cancer Associated with Papillary Thyroid Microcarcinoma, a Confusing Pathology-Essential Role of Functional Imaging
by Doina Piciu, Alexandru Meșter, Calin Căinap, Elena Bărbuș, Dragos-Stefan Morariu and Andra Piciu
Diagnostics 2020, 10(5), 270; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics10050270 - 30 Apr 2020
Cited by 2 | Viewed by 5766
Abstract
The revolution of imaging in medicine leads to new standards of care, mostly in specialties like oncology, neurology, or endocrinology. We present a review of the literature and a case report of a 62-year-old patient initially treated for a benign gynecologic pathology and [...] Read more.
The revolution of imaging in medicine leads to new standards of care, mostly in specialties like oncology, neurology, or endocrinology. We present a review of the literature and a case report of a 62-year-old patient initially treated for a benign gynecologic pathology and followed-up for 7 years clinically, with serologic and with multiple imaging techniques. There is an actual growing use of highly sensitive functional imaging methods, like fluoro-deoxy-glucose (F18-FDG) positron emission tomography/computed tomography (PET/CT) in the evaluation of oncologic pathologies, staging, follow-up, and therapy response monitoring. This is the first case report described in the literature presenting the association of thyroid papillary microcarcinoma (MPTC) and supraclavicular metastasis of ovarian cancer. The study aims to underline the necessity of a complex and careful evaluation of each oncologic patient, due to the unexpected clinical presentation and rare association of diseases, sometimes leading to confusing management. Full article
(This article belongs to the Special Issue Positron Emission Tomography (PET) Imaging for Therapy Monitoring)
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