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Special Issue Editor

Dr. Kotaro Kitaya

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Guest Editor

Reproduction Clinic Osaka, Osaka, Japan
Interests: infertility; chronic endometritis; repeated implantation failure; recurrent pregnancy loss; uterine fibroids; adenomyosis; endometriosis; tubal factor; preimplantaion genetic test; microbiota; next-generation sequencing; endometrium; uterine natural killer cells; chemokines, cytokines; ovarian steroids; proteoglycans; glycosaminoglycans; adhesion molecules; transcription factors

Special Issue Information

Dear Colleagues,

Reproductive tract infections are provoked by a wide variety of bacterial, fungal, and viral species. The unique features of reproductive tract infections are that different organs (even though they are anatomically located in close proximity to each other) present different inflammatory profiles affected by different pathogens under different histologic compositions and functions, resulting in the variance in the symptomatology and progression of these diseases. Many of these local infectious diseases potentially bring about transient and/or permanent structural, histological, and functional changes, causing subfertility and infertility both in men and women.

The identification of the pathogens in reproductive tract infections is often challenging. The evolution and development of molecular biological analysis represented by next-generation sequencing enabled us to learn about the comprehensive composition and localization of the microorganisms in human organs under physiologic and pathologic conditions. These new biomolecular technologies have great potential to help discover the novel pathogens and local microbial environments in reproductive tract infections, leading to the development of new diagnostic and therapeutic strategies.

The aim of this Special Issue is to advance our understanding of the new approaches for the diagnosis and treatment of reproductive tract infections by inviting articles ranging from original research and reviews to meta-analyses regarding these topics. Submission of basic and clinical, male and female human studies is very welcome.

Dr. Kotaro Kitaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

adenomyosis
bacterial vaginosis
chronic endometritis
chlamydia
dysbiosis
endometrial hyperplasia/cancer
endometriosis
eubiosis
human papilloma virus infection
leukospermia
microbiota
mycoplasma
uterine fibroids/leiomyoma

Published Papers (2 papers)

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Research

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11 pages, 1029 KiB

Open AccessArticle

Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study

by Elena Scaglione, Giuseppe Mantova, Valeria Caturano, Luca Fanasca, Francesca Carraturo, Fabrizio Farina, Caterina Pagliarulo, Mariateresa Vitiello, Chiara Pagliuca, Paola Salvatore and Roberta Colicchio

Diagnostics 2022, 12(8), 1798; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12081798 - 25 Jul 2022

Cited by 2 | Viewed by 1229

Abstract

This study provides updated information on the prevalence and co-infections caused by genital microorganisms and pathogens: Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, Trichomonas vaginalis, and Gardnerella vaginalis, by retrospectively analyzing a cohort of patients living in the Naples metropolitan area, Campania region, Southern Italy. To investigate the genital infections prevalence in clinical specimens (vaginal/endocervical swabs and urines) collected from infertile asymptomatic women and men from November 2018 to December 2020, we used a multiplex real-time PCR assay. Of the 717 specimens collected, 302 (42.1%) resulted positive for at least one of the targets named above. Statistically significant differences in genital prevalence of selected microorganisms were detected in both women (62.91%) and men (37.08%). G. vaginalis and U. parvum represented the most common findings with an 80.2% and 16.9% prevalence in vaginal/endocervical swabs and first-voided urines, respectively. Prevalence of multiple infections was 18.18% and 8.19% in women and men, respectively. The most frequent association detected was the co-infection of G. vaginalis and U. parvum with 60% prevalence. Our epidemiological analysis suggests different infection patterns between genders, highlighting the need to implement a preventative screening strategy of genital infections to reduce the complications on reproductive organs. Full article

(This article belongs to the Special Issue Reproductive Tract Infections: Advances in Diagnosis and Treatment)

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8 pages, 2717 KiB

Open AccessCase Report

Atypical Polypoid Adenomyoma of the Vagina: Follow Up and Subsequent Evolution: A Case Report and Update

by Melinda Ildiko Mitranovici, Ioan Emilian Oală, Izabella Petre, Marius Lucian Craina, Silviana Narcisa Floruț, Diana Maria Chiorean, Iuliu Gabriel Cocuz, Sabin Gligore Turdean, Ovidiu Simion Cotoi and Lucian Pușcașiu

Diagnostics 2022, 12(2), 368; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12020368 - 01 Feb 2022

Cited by 1 | Viewed by 2048

Abstract

Atypical polypoid adenomyoma (APA) is a rare tumor developed from a mix of cells of epithelial and mesenchymal origin. We present the case of an 84-year-old patient with atypical polypoid adenomyoma on the vaginal vault, after total hysterectomy with total adnexectomy for endometrial hyperplasia with atypia four years ago. Not following regular indicated gynecological appointments, the symptoms presented were vaginal bleeding and anemia. The importance of the case consists both in the unique way in which the adenomyoma appears on the vaginal vault and in the subsequent evolution of this pathology. After complete resection, it recurs in five months with a malignant transformation into carcinosarcoma. This fact shows that adenomas can turn not only into carcinomas but also the mesenchymal component can progress to sarcoma, a fact of exceptional rarity. Follow-up and accurate diagnosis are essential for proper management, which is a challenge anyway due to the lack of case studies. Full article

(This article belongs to the Special Issue Reproductive Tract Infections: Advances in Diagnosis and Treatment)

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