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Diagnostics
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Clinical and Pathological Approach of Head and Neck Tumor
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Clinical and Pathological Approach of Head and Neck Tumor

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 10685

Special Issue Editors

Dr. Seiichiro Makihara

E-Mail Website
Guest Editor
Dept of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital, Marugame, Japan
Interests: endoscopic sinus surgery; paranasal sinus tumor; sinusitis; endoscopic skull base surgery
Prof. Dr. Yasuharu Sato

E-Mail Website
Guest Editor
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama 7008558, Japan
Interests: hematopathology; lymphoproliferative disorders; Castleman disease; igG4-related disease; immunodeficiency-associated lymphoproliferative disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, checkpoint inhibitors are being combined with existing chemotherapy to increase treatment options in addition to surgery and radiation for many cancer types of the head and neck. Biomarkers are becoming increasingly important to optimize the prioritization and combination of these treatment options. On the other hand, benign tumors are generally treated with surgery, but there are some tumors such as sinonasal inverted papilloma that can recur or become malignant, and the etiology and risk factors are not fully understood.

Additionally, although human papillomavirus is well known to be associated with head and neck tumors, research of this topic is still developing.

This Special Issue will highlight recent advances and knowledge acquired in head and neck tumors in terms of pathology and clinical characteristics. Research revealing negative results is also welcome. We seek expert research articles, review articles, and case reports on recent advances in head and neck tumors, including future perspectives/directions.


Dr. Seiichiro Makihara
Prof. Dr. Yasuharu Sato
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck tumor
  • pathology
  • checkpoint inhibitors
  • biomarker
  • clinical characteristics
  • sinonasal inverted papilloma
  • human papillomavirus

Published Papers (5 papers)

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11 pages, 1322 KiB  
Article
Mutation Analysis of Second Primary Tumors in Oral Cancer in Taiwanese Patients through Next-Generation Sequencing
by Ting-Yuan Liu, Chien-Chin Lee, Yu-Chia Chen, Ya-Sian Chang, Hsi-Yuan Huang, Ya-Ting Lee, Ju-Chen Yen, Dysan Chao and Jan-Gowth Chang
Diagnostics 2022, 12(4), 951; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12040951 - 11 Apr 2022
Cited by 2 | Viewed by 1524
Abstract
Head and neck cancer has poor overall survival. Patients with head and neck cancer more frequently develop second primary tumors than do patients with other cancers, leading to a poor prognosis. In this study, we used next-generation sequencing to analyze and compare mutations [...] Read more.
Head and neck cancer has poor overall survival. Patients with head and neck cancer more frequently develop second primary tumors than do patients with other cancers, leading to a poor prognosis. In this study, we used next-generation sequencing to analyze and compare mutations between first tumors and second tumors in oral cancer. We retrieved tumor tissues collected from 13 patients who were diagnosed twice as having cancer. We used driver gene and trunk mutations to distinguish between recurrent cancer and primary cancer in oral cancer. We observed unique driver gene mutations in three patients with an initial clinical diagnosis of recurrent cancer; hence, we believe that the corresponding patients had primary cancer. Four patients with an initial clinical diagnosis of primary cancer were found to actually have recurrent cancer according to our results. Genetic testing can be used to enhance the accuracy of clinical diagnosis. Full article
(This article belongs to the Special Issue Clinical and Pathological Approach of Head and Neck Tumor)
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10 pages, 859 KiB  
Article
Clinicopathologic Analysis of Sinonasal Inverted Papilloma, with Focus on Human Papillomavirus Infection Status
by Munechika Tsumura, Seiichiro Makihara, Asami Nishikori, Yuka Gion, Toshiaki Morito, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Tomoyasu Tachibana, Yorihisa Orita, Shin Kariya, Mitsuhiro Okano, Mizuo Ando and Yasuharu Sato
Diagnostics 2022, 12(2), 454; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12020454 - 10 Feb 2022
Cited by 1 | Viewed by 2053
Abstract
Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP [...] Read more.
Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery. Full article
(This article belongs to the Special Issue Clinical and Pathological Approach of Head and Neck Tumor)
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11 pages, 4741 KiB  
Article
Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
by Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai and Yasuharu Sato
Diagnostics 2021, 11(12), 2284; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11122284 - 07 Dec 2021
Cited by 4 | Viewed by 2685
Abstract
Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological [...] Read more.
Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma. Full article
(This article belongs to the Special Issue Clinical and Pathological Approach of Head and Neck Tumor)
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8 pages, 3961 KiB  
Case Report
Neuroendocrine Carcinoma at the Sphenoid Sinus Misdiagnosed as an Olfactory Neuroblastoma and Resected Using High-Flow Bypass
by Kosuke Takabayashi, Takafumi Shindo, Tomoki Kikuchi and Katsumi Takizawa
Diagnostics 2022, 12(7), 1674; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12071674 - 09 Jul 2022
Viewed by 1608
Abstract
In the diagnosis of olfactory neuroblastoma (ONB), the presence of S-100–positive sustentacular cells surrounding the tumor is important; however, these are also present in normal nasal sinus epithelium. Although ONB often has a different final diagnosis, complete resection of the tumor has a [...] Read more.
In the diagnosis of olfactory neuroblastoma (ONB), the presence of S-100–positive sustentacular cells surrounding the tumor is important; however, these are also present in normal nasal sinus epithelium. Although ONB often has a different final diagnosis, complete resection of the tumor has a good prognosis and minimally affects the patient’s treatment plan. When the tumor extends around the internal carotid artery (ICA), complete resection is difficult due to the high risk of vascular injury; revascularization using high-flow bypass can avoid this complication. In the present case, the tumor was located in the left sphenoid sinus and extended around the ICA. Preoperative biopsy tissue was positive for neuroendocrine markers and slightly positive for S-100 protein, leading to a diagnosis of ectopic ONB. High-flow bypass revascularization with trapping of the ICA allowed complete tumor resection. The postoperative histopathological diagnosis was neuroendocrine carcinoma, showing no S-100 protein-positive cells. There was no sign of recurrence at 30 months after surgery without additional treatment. This case demonstrates that the presence of S-100 protein-positive cells in ONB may be misleading. Although misdiagnosis of ectopic ONB should be anticipated, a complete resection of the tumor is an effective treatment strategy. Full article
(This article belongs to the Special Issue Clinical and Pathological Approach of Head and Neck Tumor)
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8 pages, 1116 KiB  
Case Report
Sclerosing Microcystic Adenocarcinoma Arising from the Tongue: A Case Report and Literature Review
by Yi-Ying Lee, Tzer-Zen Hwang, Ying-Tai Jin and Chien-Chin Chen
Diagnostics 2022, 12(5), 1288; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics12051288 - 21 May 2022
Cited by 2 | Viewed by 1942
Abstract
Sclerosing microcystic adenocarcinoma is a rare and recently characterized cancer that affects the mucosal surfaces of the head and neck without adnexal involvement. Histologically, microcystic adnexal carcinoma of the skin resembles it. It does, however, contain unique characteristics that merit our attention for [...] Read more.
Sclerosing microcystic adenocarcinoma is a rare and recently characterized cancer that affects the mucosal surfaces of the head and neck without adnexal involvement. Histologically, microcystic adnexal carcinoma of the skin resembles it. It does, however, contain unique characteristics that merit our attention for potential diagnostic errors. Therefore, we present a 48-year-old male with sclerosing microcystic adenocarcinoma of the tongue, along with a full discussion and a brief review of pertinent literature. Full article
(This article belongs to the Special Issue Clinical and Pathological Approach of Head and Neck Tumor)
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