Role of Imaging Modalities in the Evaluation of Nonischemic Cardiomyopathy 2.0

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6603

Special Issue Editor

Department of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece
Interests: genes in genetic and inflammatory cardiomyopathies; imaging in genetic and inflammatory cardiomyopathies; brain and heart in genetic and inflammatory cardiomyopathies
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Special Issue Information

Dear Colleagues,

Patients with nonischemic cardiomyopathies (NICMs) constitute 50% of the total number of patients with cardiovascular diseases. Until recently, the only way to evaluate them was the use of left ventricular ejection fraction, which gives us a rough idea about the disease pathophysiology.

Recently, the tremendous development of various noninvasive imaging modalities has allowed for the detailed evaluation not only of the patients with NICM but also the identification of carriers and those with phenotypically mild disease. Furthermore, they facilitated the classification of various types of NICM according to disease severity and have provided useful information about disease prediction.

In this Special Issue of Diagnostics, we will describe the strong and weak points of each modality in parallel with the cost–benefit ratio for both patients and the health care system. Finally, we will focus on the clinical role of various imaging modalities in the evaluation of NICM and give an overview of the present and future perspectives of these modalities in both diagnosis and prognosis of NICM.

Prof. Dr. Sophie Mavrogeni
Guest Editor

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Keywords

  • Nonischemic cardiomyopathy
  • Echocardiography
  • SPECT
  • PET
  • Cardiovascular Magnetic Resonance
  • CT
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy
  • restrictive cardiomyopathy
  • neuromuscular disorders
  • myocardial inflammation
  • Fabry disease
  • Danon disease
  • Autoimmune rheumatic diseases
  • metabolic diseases

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Published Papers (2 papers)

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11 pages, 1772 KiB  
Article
The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by 99mTc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison
by Hung-Pin Chan, Chin-Chuan Chang, Chin Hu, Wen-Hwa Wang, Nan-Jing Peng, Yu-Chang Tyan and Ming-Hui Yang
Diagnostics 2021, 11(6), 1101; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11061101 - 16 Jun 2021
Cited by 3 | Viewed by 1978
Abstract
Heart disease is the second most common cause of mortality in Taiwan, mainly coronary artery disease (CAD).Quantitative coronary blood flow has been collected by dynamic single-photon emission computed tomography (Dynamic SPECT/CT) for CAD diagnosis in previous studies. However, few studies defined the extent [...] Read more.
Heart disease is the second most common cause of mortality in Taiwan, mainly coronary artery disease (CAD).Quantitative coronary blood flow has been collected by dynamic single-photon emission computed tomography (Dynamic SPECT/CT) for CAD diagnosis in previous studies. However, few studies defined the extent of left ventricle (LV) ischemia on Dynamic SPECT/CT for predicting significant coronary artery stenosis. This study evaluates the extent of LV ischemic blockage in patients suspected of CAD who were referred by cardiologists. A total of 181 patients with suspected CAD were enrolled. They underwent 99mTc-Sestamibi (MIBI) Dynamic SPECT/CT survey before cardiac intervention. Dynamic SPECT/CT has better sensitivity (88%), specificity (96%), and accuracy (94%) compared with those of semi-quantitative MIBI MPI (more than 10%). Results indicated that5% of the LV ischemic extent can yield positive PCI results (>70% stenosis in coronary arteries) compared with the moderate abnormal extent of at least 15% of LV. When the percentage of combined moderate abnormal extent and ischemia extent of LV reaches 27.3%, positive PCI results may be indicated. This study revealed Dynamic SPECT/CT has greater sensitivity, specificity, and accuracy as compared with MPI. Thus, the severity of abnormal perfusion extent of LV on Dynamic SPECT/CT might be beneficial to predict positive PCI results in patients with significant suspicion CAD. Full article
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29 pages, 2607 KiB  
Review
Imaging Evaluation of Pulmonary and Non-Ischaemic Cardiovascular Manifestations of COVID-19
by Sebastiano Cicco, Antonio Vacca, Christel Cariddi, Rossella Carella, Gianluca Altamura, Antonio Giovanni Solimando, Gianfranco Lauletta, Fabrizio Pappagallo, Anna Cirulli, Assunta Stragapede, Nicola Susca, Salvatore Grasso and Roberto Ria
Diagnostics 2021, 11(7), 1271; https://0-doi-org.brum.beds.ac.uk/10.3390/diagnostics11071271 - 15 Jul 2021
Cited by 7 | Viewed by 3973
Abstract
Coronavirus Disease 2019 (COVID-19) has been a pandemic challenge for the last year. Cardiovascular disease is the most described comorbidity in COVID-19 patients, and it is related to the disease severity and progression. COVID-19 induces direct damage on cardiovascular system, leading to arrhythmias [...] Read more.
Coronavirus Disease 2019 (COVID-19) has been a pandemic challenge for the last year. Cardiovascular disease is the most described comorbidity in COVID-19 patients, and it is related to the disease severity and progression. COVID-19 induces direct damage on cardiovascular system, leading to arrhythmias and myocarditis, and indirect damage due to endothelial dysfunction and systemic inflammation with a high inflammatory burden. Indirect damage leads to myocarditis, coagulation abnormalities and venous thromboembolism, Takotsubo cardiomyopathy, Kawasaki-like disease and multisystem inflammatory syndrome in children. Imaging can support the management, assessment and prognostic evaluation of these patients. Ultrasound is the most reliable and easy to use in emergency setting and in the ICU as a first approach. The focused approach is useful in management of these patients due its ability to obtain quick and focused results. This tool is useful to evaluate cardiovascular disease and its interplay with lungs. However, a detailed echocardiography evaluation is necessary in a complete assessment of cardiovascular involvement. Computerized tomography is highly sensitive, but it might not always be available. Cardiovascular magnetic resonance and nuclear imaging may be helpful to evaluate COVID-19-related myocardial injury, but further studies are needed. This review deals with different modalities of imaging evaluation in the management of cardiovascular non-ischaemic manifestations of COVID-19, comparing their use in emergency and in intensive care. Full article
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