Special Issue "Adipose Tissue Dysfunction and Recovery in Obesity and Diabetes"
Deadline for manuscript submissions: closed (20 April 2021).
Interests: pathophysiology of insulin action and insulin signaling; molecular genetics of type 2 diabetes and severe insulin resistance syndromes; gestational diabetes mellitus; pharmacogenetics of type 2 diabetes; obesity, inflammation and cancer; transcriptional regulation of glucose metabolism; mechanisms of gene regulation and transcription networks; pituitary and thyroid tumors; animal models of insulin resistance and type 2 diabetes; diagnostic and prognostic biomarkers and therapeutic targets in diabetes
Special Issues and Collections in MDPI journals
Special Issue in Endocrines: Novel Biomarkers in Endocrine and Metabolic Diseases
Interests: insulin resistance; diabetes
Adipose tissue is the largest and most heterogeneous endocrine organ, consisting of different fat depots and cell fractions (e.g. adipocytes, endothelial cells, fibroblasts and immune cells) with unique secretory features, which are able to influence almost every functional aspect of the body. In mammals, the adipose tissue grows and develops in utero according to maternal diet and glycemic state, and, if challenged in the postnatal period, may continue to expand almost indefinitely, causing obesity and related metabolic changes. Insulin resistance, the predominant metabolic consequence of obesity, poses an impending threat to the global healthcare, due to the extremely high prevalence and morbidity rates. As a key component of type 2 diabetes and other endocrine and cardiovascular disorders, insulin resistance can significantly affect life quality and expectancy of obese individuals. However, if many contributing factors have been hypothesized and tested (e.g. lipotoxicity, oxidative stress, inflammation, mitochondrial dysfunction, hypoxia), there is still no consensus about the etiology of obesity-related insulin resistance. It is generally accepted that, as a consequence of the adipose tissue dysfunction, alterations in adipokine levels impair the complexity of metabolic responses and correlate with an insulin resistant state and increased fat mass. Reduction of body weight and fat mass with healthy eating and physical activity can improve the adipose tissue dysfunction and the adipokine secretion pattern, lessening the impact of obesity and diabetes mellitus on the healthcare system. Unfortunately, most adults are unable to maintain diet-induced weight loss, while several antidiabetic agents can promote weight gain and increased body fat content. Also, in certain conditions, bariatric surgery is neither practical nor beneficial on long-term health outcomes. Thus, there is an unmet need for novel nutritional and therapeutic solutions to effectively counteract obesity and its associated metabolic alterations, a goal that requires a better understanding of the molecular mechanisms underlying adipose tissue dysfunction and the development of metabolic and inflammatory diseases.
This Special Issue of Endocrines welcomes original clinical and preclinical studies, either in in vitro cell systems and/or in in vivo experimental animal models, as well as comprehensive reviews on molecular mechanisms, emerging management paradigms, diagnostic and therapeutic advances and pitfalls in obesity and diabetes, with a special focus on adipose tissue dysfunction, adipokines and insulin resistance.
Prof. Dr. Antonio Brunetti
Dr. Eusebio Chiefari
Dr. Maria Mirabelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Endocrines is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Adipose tissue
- Insulin resistance
- Weight loss