Special Issue "Molecular Mechanisms of Estrogen Signaling Pathways"
A special issue of Endocrines (ISSN 2673-396X).
Deadline for manuscript submissions: closed (20 May 2021).
Interests: breast cancer; estrogen receptor; progesterone receptor; cell signaling; arginine methylation; arginine demethylation; post translational modifications; transcriptional regulation
Special Issues and Collections in MDPI journals
The steroid hormone estrogen plays a critical role in numerous target tissues including the reproductive tract, the nervous, vascular and skeletal systems. Its pleiotropic effects are mediated mainly by two receptors, estrogen receptor alpha (ERα) and beta (ERβ), members of the nuclear receptors family, which function as ligand-dependent transcription factors. More recently, isoforms of ERα have been identified (ERα46, ERα36) displaying different mechanisms of action and adding a level of complexity in the integration of estrogen biological effects. Estrogen signaling is highly complex as besides its classical genomic action, a non genomic pathway involving protein kinases also takes place. Moreover, interference with growth factors signaling participates in the integration of various external signals.
In addition, estrogen receptors signaling involves the recruitment of a large number of coregulators, which participates in the diversity and the specificity of biological responses. These receptors are also highly modified by post translational modifications (PTMs), such as phosphorylation, methylation and acetylation involved in the fine tuning of their activities. The complexity of ER regulation is a rapidly growing issue as new coregulators and PTMs are continuously identified. Moreover, ER is also able to interact with other members of the steroid hormone receptors family as with the progesterone receptor (PR) or the glucocorticoid receptor (GR) modulating estrogen signaling.
Understanding deeply the molecular mechanisms of estrogen signaling is an important challenge as estrogen is involved in pathology such as breast and endometrial cancers, but also to better understand how endocrine disruptors interfere with these pathways.
This special issue of Endocrines welcomes in vitro and in vivo studies as well as comprehensive reviews on estrogen molecular mechanisms, diagnostic and therapeutic advances in treatment of pathologies involving estrogens.
Dr. Muriel Le Romancer
Dr. Coralie Poulard
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Endocrines is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Estrogen receptors
- Genomic signaling
- Non genomic signaling
- Post translational modifications
- ER isoforms