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Fluids
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Frontiers in Bio-Heat Transfer
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Frontiers in Bio-Heat Transfer

A special issue of Fluids (ISSN 2311-5521). This special issue belongs to the section "Heat and Mass Transfer".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 4078

Special Issue Editor

Prof. Dr. Bohdan Mochnacki

E-Mail Website
Guest Editor
Rector of University of Occupational Safety Management in Katowice, 40-007 Katowice, Poland
Interests: mumerical modeling of physical processes; heat and mass transfer; bio-heat transfer; microscale heat transfer; modeling of solidification of metals and alloys

Special Issue Information

Dear Colleagues,

This Special Issue of Fluids shall be devoted to the broadly understood problems of bio-heat transfer. We anticipate the publication of works on “whole domain models”, local models based on the well-known Pennes equation as well as the Cattaneo–Vernotte equation or dual phase lag equation, and finally, models which take into account the presence of large, thermally significant blood vessels. Papers may also concern numerical simulations of medical procedures, such as the local heating and cooling of tissue (hypo and hyperthermia), cryosurgical treatments, etc. Works on experimental research and review articles will also be accepted.

Prof. Dr. Bohdan Mochnacki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fluids is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-heat transfer
  • Pennes equation
  • Cattaneo–Vernotte equation
  • numerical simulations
  • medical procedures

Published Papers (2 papers)

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Research

15 pages, 4428 KiB  
Article
Fluid–Structure Interaction and Non-Fourier Effects in Coupled Electro-Thermo-Mechanical Models for Cardiac Ablation
by Sundeep Singh and Roderick Melnik
Fluids 2021, 6(8), 294; https://0-doi-org.brum.beds.ac.uk/10.3390/fluids6080294 - 20 Aug 2021
Cited by 6 | Viewed by 1850
Abstract
In this study, a fully coupled electro-thermo-mechanical model of radiofrequency (RF)-assisted cardiac ablation has been developed, incorporating fluid–structure interaction, thermal relaxation time effects and porous media approach. A non-Fourier based bio-heat transfer model has been used for predicting the temperature distribution and ablation [...] Read more.
In this study, a fully coupled electro-thermo-mechanical model of radiofrequency (RF)-assisted cardiac ablation has been developed, incorporating fluid–structure interaction, thermal relaxation time effects and porous media approach. A non-Fourier based bio-heat transfer model has been used for predicting the temperature distribution and ablation zone during the cardiac ablation. The blood has been modeled as a Newtonian fluid and the velocity fields are obtained utilizing the Navier–Stokes equations. The thermal stresses induced due to the heating of the cardiac tissue have also been accounted. Parametric studies have been conducted to investigate the effect of cardiac tissue porosity, thermal relaxation time effects, electrode insertion depths and orientations on the treatment outcomes of the cardiac ablation. The results are presented in terms of predicted temperature distributions and ablation volumes for different cases of interest utilizing a finite element based COMSOL Multiphysics software. It has been found that electrode insertion depth and orientation has a significant effect on the treatment outcomes of cardiac ablation. Further, porosity of cardiac tissue also plays an important role in the prediction of temperature distribution and ablation volume during RF-assisted cardiac ablation. Moreover, thermal relaxation times only affect the treatment outcomes for shorter treatment times of less than 30 s. Full article
(This article belongs to the Special Issue Frontiers in Bio-Heat Transfer)
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17 pages, 2592 KiB  
Article
Nanoparticle Delivery in Prostate Tumors Implanted in Mice Facilitated by Either Local or Whole-Body Heating
by Qimei Gu, Lance Dockery, Marie-Christine Daniel, Charles J. Bieberich, Ronghui Ma and Liang Zhu
Fluids 2021, 6(8), 272; https://0-doi-org.brum.beds.ac.uk/10.3390/fluids6080272 - 31 Jul 2021
Cited by 3 | Viewed by 1596
Abstract
This work discusses in vivo experiments that were performed to evaluate whether local or whole-body heating to 40 °C reduced interstitial fluid pressures (IFPs) and enhanced nanoparticle delivery to subcutaneous PC3 human prostate cancer xenograft tumors in mice. After heating, 0.2 mL of [...] Read more.
This work discusses in vivo experiments that were performed to evaluate whether local or whole-body heating to 40 °C reduced interstitial fluid pressures (IFPs) and enhanced nanoparticle delivery to subcutaneous PC3 human prostate cancer xenograft tumors in mice. After heating, 0.2 mL of a previously developed nanofluid containing gold nanoparticles (10 mg Au/mL) was injected via the tail vein. The induced whole-body hyperthermia led to increases in tumor and mouse body blood perfusion rates of more than 50% and 25%, respectively, while the increases were much smaller in the local heating group. In the whole-body hyperthermia groups, the IFP reduction from the baseline at the tumor center immediately after heating was found to be statistically significant when compared to the control group. The 1 h of local heating group showed IFP reductions at the tumor center, while the IFPs increased in the periphery of the tumor. The intratumoral gold nanoparticle accumulation was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Compared to the control group, 1 h or 4 h of experiencing whole-body hyperthermia resulted in an average increase of 51% or 67% in the gold deposition in tumors, respectively. In the 1 h of local heating group, the increase in the gold deposition was 34%. Our results suggest that 1 h of mild whole-body hyperthermia may be a cost-effective and readily implementable strategy for facilitating nanoparticle delivery to PC3 tumors in mice. Full article
(This article belongs to the Special Issue Frontiers in Bio-Heat Transfer)
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