Special Issue "The Non-equilibrium Thermodynamic Foundations of Fundamental Problems from Nature"

A special issue of Foundations (ISSN 2673-9321). This special issue belongs to the section "Physical Sciences".

Deadline for manuscript submissions: 30 June 2022.

Special Issue Editor

Dr. Karo Michaelian
E-Mail Website
Guest Editor
Instítuto de Física, Universidad Nacional Autónoma de México, Mexico City 01000, Mexico
Interests: origin of life; homochirality; ecosystems; non-equilibrium thermodynamics; dissipative structuring
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few decades, the application of the physical framework known as “non-equilibrium thermodynamics” has allowed a greater understanding of difficult unresolved problems from Nature. Non-equilibrium thermodynamics brings out dynamical and emergent phenomena of many-body systems involving an extremely large number of microscopic degrees of freedom under a generalized thermodynamic potential. These phenomena, which arise when complex material is driven far from equilibrium, are very different from the phenomena found close to equilibrium and include dissipative structuring, space-time symmetry breaking, multiple stationary states, evolution over stationary states, history, and entropy production.

Some of the most difficult problems which have benefitted from such a non-equilibrium thermodynamic perspective include the origin and evolution of the universe (Big Bang), the origin of the second law of thermodynamics, the origin and meaning of time, the origin of complexity, the origin and meaning of dark energy, the universal particle–antiparticle asymmetry, the origin and evolution of life, the homochirality of life, global warming, understanding and controlling cancer, and understanding brain dynamics.

This Special Issue reviews the progress that has been made in these difficult fields through applying non-equilibrium thermodynamic formalism to these unresolved problems. Each review will be written in simple language for the non-expert, thereby allowing the utility of the non-equilibrium framework to be appreciated by those with little background in non-equilibrium thermodynamics and bringing wider recognition to your novel perspective on the problem.

Since Foundations is a new journal of the open-access publisher MDPI, the journal is offering to publish invited papers in this Special Issue free of charge. However, it is important that your intentions to publish a paper for this Special Issue are conveyed to us at the earliest possible date so that adequate planning of the Issue and its timely publication can be achieved.

Dr. Karo Michaelian
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foundations is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • non-equilibrium thermodynamics
  • Big Bang
  • dark energy
  • cosmology
  • particle–antiparticle asymmetry
  • origin of life
  • homochirality
  • meaning of time
  • origin of complexity
  • cancer
  • the second law of thermodynamics

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Non-equilibrium Thermodynamic Foundations of the Origin of Life
Authors: Karo Michaelian
Affiliation: Institute of Physics, Universidad Nacional Autonoma de México (UNAM)

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