Special Issue "Recent Developments in Redox Biochemistry and Pharmacology"

A special issue of Foundations (ISSN 2673-9321). This special issue belongs to the section "Medical Sciences".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Marcelo Farina
E-Mail Website
Guest Editor
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brasil
Interests: neuropathology; neuropharmacology; redox biology
Dr. Nora Gray
E-Mail Website
Guest Editor
Neurology Department, Oregon Health and Science University, Portland, OR, USA
Interests: cognitive function; mitochondrial biology; therapeutic targeting of antioxidant response pathway; neurodegenerative disease

Special Issue Information

Dear Colleagues,

In the last few decades, our understanding about the importance of redox-mediated events for the proper functioning of cells and systems has increased substantially. A growing body of evidence has shown that, in addition to the deleterious effects on biomolecules, oxidants also play a key role in maintaining aerobic cell homeostasis, allowing for the existence of oxidative eustress. On the other hand, the rupture of this oxidative/reductive homeostasis has been associated with several acute and chronic pathological conditions, such as ischemia-reperfusion injury and chronic neurodegenerative disease.

In particular, redox regulation has become recognized as an important factor in chronic neurodegenerative conditions. The brain is especially sensitive to changes in cellular redox status, therefore the maintenance of redox homeostasis is critical to preventing damage. The abnormal accumulation of redox intermediaries and increased oxidative stress are features that are common to most neurological conditions, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, stroke, traumatic brain injury, amyotrophic lateral sclerosis, and others. Because the cellular consequences of oxidative damage contribute to the degeneration of a variety of cell types, interventions that target redox biochemistry could have tremendous therapeutic value across a wide range of neurological diseases.

In this scenario, studies on the search for endogenous and exogenous molecules that directly or indirectly modulate these redox-mediated events have been conducted in an attempt to find pharmacological strategies to mitigate the deleterious effects of oxidative distress.

Unfortunately, antioxidant therapies have not proven to be effective in most clinical studies for different possible reasons that are reviewed elsewhere. However, the modulation of oxidative stress and, in particular, the activation or inhibition of redox-related transcription factors (i.e., Nrf2, FOXO, etc.) are considered to be important strategies for the development of new drugs for some of the aforementioned pathologies, such as cardiovascular and neoplastic diseases that are resistant to other treatments.

The main aim of this Special Issue is to address different chemical, biological, physiological, pharmaceutical, and pharmacological aspects of research on the modulation of redox-mediated events related to oxidative or reductive stress in biological systems. Potential topics include but are not limited to the following:

  • The synthesis and derivatization of drugs with potential pharmacological applications to modulate redox-mediated events in biological systems;
  • Mechanism of action of redox compounds, with special attention to molecular signaling pathways, including Nrf2;
  • Pharmacokinetics, metabolic pathways, and the redox activity of metabolites;
  • In vitro and in vivo studies on the pharmacological activity of redox compounds;
  • Epidemiological and clinical studies on the efficacy of redox therapies;
  • Relevant biological markers to assess in vivo antioxidant/prooxidant action and its correlation with clinical efficacy.

Prof. Dr. Luciano Saso
Prof. Marcelo Farina
Dr. Nora Gray
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foundations is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Redox compounds;
  • Antioxidants;
  • Modulation of oxidative stress;
  • Molecular signaling pathways;
  • Nrf2

Published Papers

This special issue is now open for submission.
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