Molecular Alterations in Gastrointestinal Pre-invasive Lesions 2022

Dear Colleagues,

The relatively recent comprehensive molecular characterization of gastrointestinal tumors has demonstrated that similar oncogenetic pathways are shared among different types of cancers. This represents the biological rationale for the development and introduction into clinical practice of targeted therapies and for the optimization of the already available chemotherapeutic drugs. Moreover, significant intra-tumor genomic and epigenomic heterogeneity has been observed, resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling. Despite these important information, complete molecular data on pre-invasive lesions of the gastrointestinal tract are still limited, significantly affecting the diagnostic process and treatment of gastrointestinal “early” lesions. The research topic aims to study: (i) the clinico-pathological features and their matched molecular characteristics distinguishing pre-invasive (early) gastrointestinal lesions; (ii) the identification of novel molecular markers, which can be useful in the identification of the neoplastic precursors/preinvasive lesions; (iii) the identification of novel molecular biomarkers to be implemented in the secondary prevention strategies of invasive gastrointestinal tumors.

Prof. Dr. Matteo Fassan
Prof. Dr. Luca Saragoni
Guest Editors

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• gastrointestinal cancer
• early diagnosis
• molecular markers
• non-invasive treatments