Crohn's Disease: Symptoms, Causes, Management and Treatment

A special issue of Gastrointestinal Disorders (ISSN 2624-5647).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3454

Special Issue Editor

Division of Surgery, Department of Clinical And Experimental Medicine, University of Florence, AOU Careggi Hospital, 50139 Florence, Italy
Interests: inflammatory bowel diseases; endocrine surgery; general oncologic surgery; mini-invasive surgery

Special Issue Information

Dear Colleagues,

Chronic inflammation is a major risk factor for various human diseases. Inflammatory bowel diseases are the best abdominal example of this. Although many studies have focused on the steps of the inflammatory responses in the last several decades, further experiences are required for the effective understanding of the pathogenesis of this heterogeneous group of diseases. Moreover, there is a great need for studies able to clarify specific issues about clinical aspects of Crohn’s disease. This Special Issue aims to highlight the latest research about this topic. We invite researchers to contribute with original research, review articles, nonclinical studies and translational/clinical studies focusing not only on the roles of integrome but also on potential therapeutic targets for medical or surgical treatments.

Dr. Francesco Giudici
Guest Editor

Manuscript Submission Information

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Keywords

  • inflammatory bowel diseases
  • Crohn’s disease
  • surgery
  • gastroenterology
  • pathogenesis
  • therapy
  • integrome

Published Papers (1 paper)

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4 pages, 222 KiB  
Opinion
Crohn’s Disease: The infectious Disease Incorporated’s Perspective
by Gilles R.G. Monif
Gastrointest. Disord. 2021, 3(3), 138-141; https://0-doi-org.brum.beds.ac.uk/10.3390/gidisord3030015 - 25 Aug 2021
Cited by 1 | Viewed by 2699
Abstract
Infectious Diseases Incorporated (IDI) is an infectious disease think-tank, established in 1973. Crohn’s disease (CD) is a chronic, recurrent disease of the gastrointestinal tract that has reached epidemic proportions within industrialized nations. CD is said to be without cure. Since 2003, therapeutic interventions [...] Read more.
Infectious Diseases Incorporated (IDI) is an infectious disease think-tank, established in 1973. Crohn’s disease (CD) is a chronic, recurrent disease of the gastrointestinal tract that has reached epidemic proportions within industrialized nations. CD is said to be without cure. Since 2003, therapeutic interventions have focused on disruption of the pro-inflammatory Th1 response against an unknown antigen. In 2015, the Hruska Postulate was introduced and, in so doing, explained how, in the absence of acquired immunity, newborn infection by Mycobacterium avium subspecies paratuberculosis could cause fixation of the immune system’s Th1 response against the organism. The Hruska Postulate was utilized to answer all the documented epidemiological facts embedded in the natural history of Crohn’s disease and, in particular, why breastfeeding confers protection against the future development of Crohn’s disease. It is Infectious Diseases Incorporated’s (IDI) stated opinion that Crohn’s disease is both preventable and curable if treated appropriately in its early stages. Full article
(This article belongs to the Special Issue Crohn's Disease: Symptoms, Causes, Management and Treatment)
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