Special Issue "Nanoparticle-Hydrogel Composites for Biomedical Applications: Volume II"

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 July 2021).

Special Issue Editor

Dr. Andrea Atrei
E-Mail Website
Guest Editor
Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro 2, 53100 Siena, Italy
Interests: surface science; structure; properties and reactivity of solid surfaces; properties of nanostructured materials
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Special Issue Information

Dear Colleagues,

Embedding inorganic, organic, or biological nanoparticles in hydrogels allows one to prepare hybrid materials which are capable of responding to a variety of stimuli from the surrounding environment. Nanoparticles can be simply entrapped in hydrogels, prepared inside the hydrogels, or functionalized to work as a crosslinker of polymer chains. Incorporation of nanoparticles into hydrogels modifies the swelling degree and the physicochemical and mechanical properties of the polymer network. In the case of magnetic nanoparticles, the application of static/alternating magnetic fields offers the possibility of addressing and remotely modulating drug release from hydrogels.

Dr. Andrea Atrei
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogels
  • Nanoparticles
  • Polymers
  • Hybrid materials
  • Drug release
  • Chemical, mechanical, biological properties

Published Papers (1 paper)

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Research

Article
The Manufacture and Characterization of Silver Diammine Fluoride and Silver Salt Crosslinked Nanocrystalline Cellulose Films as Novel Antibacterial Materials
Gels 2021, 7(3), 104; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7030104 - 27 Jul 2021
Viewed by 498
Abstract
There is an unmet need for biocompatible, anti-infective, and mechanically strong hydrogels. This study investigated the use of poly vinyl alcohol (PVA), polysaccharides, and nanocrystalline cellulose (CNC) to deliver silver in a controlled manner for possible use against oral or wound bacteria. Silver [...] Read more.
There is an unmet need for biocompatible, anti-infective, and mechanically strong hydrogels. This study investigated the use of poly vinyl alcohol (PVA), polysaccharides, and nanocrystalline cellulose (CNC) to deliver silver in a controlled manner for possible use against oral or wound bacteria. Silver was included in solvent cast films as silver diammine fluoride (SDF) or as nitrate, sulphate, or acetate salts. Hydrogel formation was assessed by swelling determinations and silver release was measured using inductively coupled plasma methods. Antibacterial studies were performed using Gram-positive and negative bacteria turbidity assays. PVA formed homogenous, strong films with SDF and swelled gently (99% hydrolyzed) or vigorously with dissolution (88% hydrolyzed) and released silver slowly or quickly, respectively. CNC-SDF films swelled over a week and formed robust hydrogels whereas CNC alone (no silver) disintegrated after two days. SDF loaded CNC films released silver slowly over 9 days whereas films crosslinked with silver salts were less robust and swelled and released silver more quickly. All silver loaded films showed good antibacterial activity. CNC may be crosslinked with silver in the form of SDF (or any soluble silver salt) to form a robust hydrogel suitable for dental use such as for exposed periodontal debridement areas. Full article
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