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Gels
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Gels for Cardiac Tissue Regeneration
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Gels for Cardiac Tissue Regeneration

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (7 January 2022) | Viewed by 7737

Special Issue Editor

Prof. Dr. Nasim Annabi

grade E-Mail Website
Guest Editor
Department of Chemical Engineering, University of California, Los Angeles, CA 90095, USA
Interests: biomaterials; tissue engineering; tissue adhesives; sealants; surgical glues; nanomaterials; regenerative medicine; hydrogels; scaffolds; elastin-like polypeptides; elastic biomaterials; photo-crosslinking
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of tissue engineering has been steadily evolving towards the development of biomimetic constructs that recapitulate the structural and functional complexity of human tissues. In this regard, the incorporation of state-of-the-art microfabrication techniques, and hydrogel-based biomaterials has allowed the engineering of accurate in vitro models, which are being widely used for fundamental and translational biomedical research. 

The ability to engineer tissue constructs with an unprecedented level of physiological accuracy has greatly benefited the field of cardiovascular tissue engineering. These advanced in vitro systems are being used to enhance our understanding of the pathophysiological mechanisms that underlie cardiovascular diseases, as well as platforms with enhanced predictive power for high-throughput drug screening and discovery. In addition, these experimental platforms are bridging the gap between conventional in vitro cultures and more relevant in vivo models, by circumventing the high costs, resources, and ethical concerns associated with the use of animals for experimentation. Furthermore, the engineering of artificial blood vessels, heart valves, and myocardial tissues will have profound implications in the field of regenerative medicine and cardiovascular surgical procedures. 

This Special Issue focuses on the development of advanced hydrogels, as well as their incorporation with cutting-edge biofabrication techniques to engineer novel cardiovascular tissue constructs. In particular, emphasis is being added on the use of smart hydrogels to recapitulate the biochemical, mechanical, electrical, and architectural properties of cardiovascular tissues for different biomedical applications.

We look forward to receiving your contributions to this Special Issue.

Prof. Dr. Nasim Annabi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cardiovascular tissue engineering
  • Hydrogel
  • Biomaterials
  • Microfabrication
  • In vivo models
  • Regenerative medicine

Published Papers (2 papers)

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Research

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11 pages, 2712 KiB  
Article
Local Use of Hydrogel with Amiodarone in Cardiac Surgery: Experiment and Translation to the Clinic
by Vladimir Shvartz, Teymuraz Kanametov, Maria Sokolskaya, Andrey Petrosyan, Tatyana Le, Olga Bockeria and Leo Bockeria
Gels 2021, 7(1), 29; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7010029 - 10 Mar 2021
Cited by 5 | Viewed by 2234
Abstract
The objective of this study was to study the use of the hydrogel biopolymer based on sodium alginate (“Colegel”) with a drug substance—amiodarone—for the prevention of postoperative atrial fibrillation (POAF) in cardiac surgery. The experimental part of the study was performed on 46 [...] Read more.
The objective of this study was to study the use of the hydrogel biopolymer based on sodium alginate (“Colegel”) with a drug substance—amiodarone—for the prevention of postoperative atrial fibrillation (POAF) in cardiac surgery. The experimental part of the study was performed on 46 rabbits. Five groups were formed: in the first group, the dose of amiodarone in hydrogel was 1 mg; in the second group—3 mg; in the third group—6 mg; in the fourth group, hydrogel was used without amiodarone; in the fifth group, 60 mg amiodarone was administered intravenously. The animals from each group were removed from the experiment for the pathomorphological study of the heart after 3, 7 and 14 days. The studied endpoints were: the heart rate control; the development of the blockades of the conduction system of the heart; and the development of inflammation according to laboratory pathomorphological studies. The translational clinical part involved a randomized clinical trial which included 60 patients, with an average age of 62 ± 8.5 years. All patients were randomized into two groups: the study group (n = 30, with the application of amiodarone hydrogel) and the control group (n = 30, without the application of amiodarone hydrogel). The dose of amiodarone in the hydrogel material was 60 mg for all patients. The heart rhythm was monitored during 5 days. The primary endpoint was the development of POAF. Secondary endpoints were: the dynamics of heart rate; the duration of the QT and PQ intervals; the development of blockades of the cardiac conduction system; as well as the dynamics of AST and ALT. According to the results of the experimental part, it was found that the method of the local epicardial delivery of amiodarone by the hydrogel material was safe. Hydrogel with amiodarone is effective for reducing the heart rate in the animal experiment in comparison to the control group and the group with the intravenous administration of the drug. The optimal dose of amiodarone in hydrogel was 1 mg per 1 kg. According to the results of the clinical part, it was found that the method of the local epicardial delivery of amiodarone as a hydrogel material proved its safety. Hydrogel with amiodarone at a dose of 60 mg was effective in preventing POAF in patients after coronary artery bypass grafting (CABG) operations in comparison to the control group (p < 0.001). The age and procedure of application of the amiodarone gel were significantly associated with POAF (p = 0.009 and p = 0.011, respectively). The use of hydrogel with amiodarone reduced the probability of developing POAF 18.9-fold. The method of the local epicardial delivery of amiodarone in the form of a hydrogel material is safe. The use of hydrogel with amiodarone after CABG reduced the probability of developing POAF. Full article
(This article belongs to the Special Issue Gels for Cardiac Tissue Regeneration)
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Review

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21 pages, 1472 KiB  
Review
Injectable Hydrogels for Improving Cardiac Cell Therapy—In Vivo Evidence and Translational Challenges
by Cecilie Hoeeg, Alireza Dolatshahi-Pirouz and Bjarke Follin
Gels 2021, 7(1), 7; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7010007 - 22 Jan 2021
Cited by 24 | Viewed by 4690
Abstract
Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has [...] Read more.
Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the cell products in the heart. It has been shown that improving retention often leads to improved functional outcome. A feasible method of improving cell graft retention is administration of injectable hydrogels. Over the last decade, a variety of injectable hydrogels have been investigated preclinically for their potential to improve the effects of cardiac cell therapy. These hydrogels are created with different polymers, properties, and additional functional motifs and differ in their approaches for encapsulating different cell types. Only one combinational therapy has been tested in a clinical randomized controlled trial. In this review, the latest research on the potential of injectable hydrogels for delivery of cell therapy is discussed, together with potential roadblocks for clinical translation and recommendations for future explorations to facilitate future translation. Full article
(This article belongs to the Special Issue Gels for Cardiac Tissue Regeneration)
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