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Gels
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Hydrogels for Drug Delivery 2020
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Hydrogels for Drug Delivery 2020

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 20290

Special Issue Editor

Dr. Monica Serban

E-Mail Website
Guest Editor
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
Interests: biomaterials for drug delivery into the ear

Special Issue Information

Dear Colleagues,

Many critical clinical problems have been shown to benefit from topical presentation of therapeutic agents, primarily through the elimination of side effects associated with systemic drug treatments. Hydrogels have been particularly appealing for such applications. Their constituent high water content and the physically or chemically crosslinked polymeric network allow control over hydrogel physicochemical properties, biodegradability, and overall spatiotemporal control of drug release profiles.

This Special Issue is intended to highlight new approaches to hydrogel-based drug delivery systems design, drug incorporation, characterization, deployment, and applications.

Dr. Monica Serban
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogels
  • Drug loading
  • Drug release
  • Biodegradability
  • Spatiotemporal release

Published Papers (4 papers)

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Research

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17 pages, 7671 KiB  
Article
A Rapid Crosslinkable Maleimide-Modified Hyaluronic Acid and Gelatin Hydrogel Delivery System for Regenerative Applications
by Kyung Min Yoo, Sean V. Murphy and Aleksander Skardal
Gels 2021, 7(1), 13; https://0-doi-org.brum.beds.ac.uk/10.3390/gels7010013 - 01 Feb 2021
Cited by 12 | Viewed by 5247
Abstract
Hydrogels have played a significant role in many applications of regenerative medicine and tissue engineering due to their versatile properties in realizing design and functional requirements. However, as bioengineered solutions are translated towards clinical application, new hurdles and subsequent material requirements can arise. [...] Read more.
Hydrogels have played a significant role in many applications of regenerative medicine and tissue engineering due to their versatile properties in realizing design and functional requirements. However, as bioengineered solutions are translated towards clinical application, new hurdles and subsequent material requirements can arise. For example, in applications such as cell encapsulation, drug delivery, and biofabrication, in a clinical setting, hydrogels benefit from being comprised of natural extracellular matrix-based materials, but with defined, controllable, and modular properties. Advantages for these clinical applications include ultraviolet light-free and rapid polymerization crosslinking kinetics, and a cell-friendly crosslinking environment that supports cell encapsulation or in situ crosslinking in the presence of cells and tissue. Here we describe the synthesis and characterization of maleimide-modified hyaluronic acid (HA) and gelatin, which are crosslinked using a bifunctional thiolated polyethylene glycol (PEG) crosslinker. Synthesized products were evaluated by proton nuclear magnetic resonance (NMR), ultraviolet visibility spectrometry, size exclusion chromatography, and pH sensitivity, which confirmed successful HA and gelatin modification, molecular weights, and readiness for crosslinking. Gelation testing both by visual and NMR confirmed successful and rapid crosslinking, after which the hydrogels were characterized by rheology, swelling assays, protein release, and barrier function against dextran diffusion. Lastly, biocompatibility was assessed in the presence of human dermal fibroblasts and keratinocytes, showing continued proliferation with or without the hydrogel. These initial studies present a defined, and well-characterized extracellular matrix (ECM)-based hydrogel platform with versatile properties suitable for a variety of applications in regenerative medicine and tissue engineering. Full article
(This article belongs to the Special Issue Hydrogels for Drug Delivery 2020)
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10 pages, 2702 KiB  
Article
Tetraethyl Orthosilicate-Based Hydrogels for Drug Delivery—Effects of Their Nanoparticulate Structure on Release Properties
by Bogdan A. Serban, Emma Barrett-Catton and Monica A. Serban
Gels 2020, 6(4), 38; https://0-doi-org.brum.beds.ac.uk/10.3390/gels6040038 - 28 Oct 2020
Cited by 8 | Viewed by 3528
Abstract
Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, [...] Read more.
Tetraethyl orthosilicate (TEOS)-based hydrogels, with shear stress response and drug releasing properties, can be formulated simply by TEOS hydrolysis followed by volume corrections with aqueous solvents and pH adjustments. Such basic thixotropic hydrogels (thixogels) form via the colloidal aggregation of nanoparticulate silica. Herein, we investigated the effects of the nanoparticulate building blocks on the drug release properties of these materials. Our data indicate that the age of the hydrolyzed TEOS used for the formulation impacts the nanoparticulate structure and stiffness of thixogels. Moreover, the mechanism of formation or the disturbance of the nanoparticulate network significantly affects the release profiles of the incorporated drug. Collectively, our results underline the versatility of these basic, TEOS-only hydrogels for drug delivery applications. Full article
(This article belongs to the Special Issue Hydrogels for Drug Delivery 2020)
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11 pages, 1958 KiB  
Article
Elucidating the Structure-Function Relationship of Solvent and Cross-Linker on Affinity-Based Release from Cyclodextrin Hydrogels
by Sean T. Zuckerman, Edgardo Rivera-Delgado, Rebecca M. Haley, Julius N. Korley and Horst A. von Recum
Gels 2020, 6(1), 9; https://0-doi-org.brum.beds.ac.uk/10.3390/gels6010009 - 22 Mar 2020
Cited by 8 | Viewed by 2756
Abstract
Minocycline (MNC) is a tetracycline antibiotic capable of associating with cyclodextrin (CD), and it is a frontline drug for many instances of implant infection. Due to its broad-spectrum activity and long half-life, MNC represents an ideal drug for localized delivery; however, classic polymer [...] Read more.
Minocycline (MNC) is a tetracycline antibiotic capable of associating with cyclodextrin (CD), and it is a frontline drug for many instances of implant infection. Due to its broad-spectrum activity and long half-life, MNC represents an ideal drug for localized delivery; however, classic polymer formulations, particularly hydrogels, result in biphasic release less suitable for sustained anti-microbial action. A polymer delivery system capable of sustained, steady drug delivery rates poses an attractive target to maximize the antimicrobial activity of MNC. Here, we formed insoluble hydrogels of polymerized CD (pCD) with a range of crosslinking densities, and then assessed loading, release, and antimicrobial activity of MNC. MNC loads between 5–12 wt % and releases from pCD hydrogels for >14 days. pCD loaded with MNC shows extended antimicrobial activity against S. aureus for >40 days and E. coli for >70 days. We evaluated a range of water/ethanol blends to test our hypothesis that solvent polarity will impact drug-CD association as a function of hydrogel swelling and crosslinking. Increased polymer crosslinking and decreased solvent polarity both reduced MNC loading, but solvent polarity showed a dramatic reduction independent of hydrogel swelling. Due to its high solubility and excellent delivery profile, MNC represents a unique drug to probe the structure-function relationship between drug, affinity group, and polymer crosslinking ratio. Full article
(This article belongs to the Special Issue Hydrogels for Drug Delivery 2020)
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Review

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31 pages, 3776 KiB  
Review
Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
by Esfandyar Askari, Amir Seyfoori, Meitham Amereh, Sadaf Samimi Gharaie, Hanieh Sadat Ghazali, Zahra Sadat Ghazali, Bardia Khunjush and Mohsen Akbari
Gels 2020, 6(2), 14; https://0-doi-org.brum.beds.ac.uk/10.3390/gels6020014 - 08 May 2020
Cited by 56 | Viewed by 7741
Abstract
Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and [...] Read more.
Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted. Full article
(This article belongs to the Special Issue Hydrogels for Drug Delivery 2020)
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