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Recent Advances on Nanogel Engineering for Drug Delivery

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A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 11013

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Special Issue Editors

Dr. Francisco Fernández-Campos

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Guest Editor

Laboratory Reig Jofre, Avda. Del Flors s/n, 08970 Sant Joan Despi, Barcelona, Spain
Interests: nanotechnology; topical administration; skin permeation; drug release; colloidal systems; skin delivery; vaginal delivery; oral delivery; ocular delivery; drug delivery
Special Issues, Collections and Topics in MDPI journals

Dr. Mireia Mallandrich Miret

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Guest Editor

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Interests: nanocarriers; topical drug delivery systems; dermal absorption; skin models; in vitro studies; nanomedicine; transdermal delivery; transmucosal delivery; cronocosmetic; skin biodistribution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanogels are promising drug delivery systems for different administration routes (oral, parenteral, or topical), due to their biocompatibility, biodegradability, and nanometric range, which allow them to modify the biological properties and the pharmacokinetic profile. Advances in polymer sciences and polymer structural modifications give interesting nanogel properties, for example, responsiveness to different stimuli (pH, temperature, ionic strength, endogenous compounds, etc.), improved adhesion to biological surfaces, or improved antimicrobiological properties, among others. In addition, advances in nanogel manufacturing processes can improve the efficiency of the drug delivery system and offer a more realistic approach for real patient administration. Several therapeutic agents could be loaded into nanogels, from small chemical entities and natural products to biologics.

We propose this Special Issue on “Recent Advances on Nanogel Engineering for Drug Delivery” to offer up-to-date information regarding the potential use of nanogels to treat different diseases and novel approaches, including new manufacturing and composition properties focusing on biomedical applications. Research and review manuscripts are welcome.

Dr. Francisco Fernández-Campos
Dr. Mireia Mallandrich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Nanogel
Drug delivery
Biomedical applications
Topical administration
Oral administration
Ocular administration
Parenteral administration
Stimuli-responsive nanogels

Published Papers (3 papers)

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Research

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14 pages, 3684 KiB

Open AccessArticle

Gelatinase Responsive Nanogel for Antibacterial Phototherapy and Wound Healing

by Qianqian Han, Xuan Wang, Lin Qiu, Xinpei Zhou, Zexuan Hui, Xinye Ni, Yang Xuan, Xiaoling Lei and Jianhao Wang

Gels 2022, 8(7), 397; https://0-doi-org.brum.beds.ac.uk/10.3390/gels8070397 - 23 Jun 2022

Cited by 4 | Viewed by 1847

Abstract

The unique bactericidal mechanism of metal nanoparticles (MNPs) is considered to be an effective strategy to deal with antibiotic resistance, but the oxidative stress damage caused by excessive accumulation of MNPs to normal cells cannot be ignored. Achieving on-demand release of nano-drugs in specific infection environments is highly attractive. Herein, we constructed a “core-shell” nanogel (G@CuS) based on a copper sulfide (CuS) antimicrobial agent and gelatin for targeted drug release and bacterial clearance in a gelatinase infected microenvironment. G@CuS produced heat and reactive oxygen species (ROS) under the irradiation of a laser, which together with the released Cu²⁺ cause irreversible and efficient physical damage to the bacteria. Moreover, the encapsulation of gelatin not only limits the biotoxicity of CuS nanodots (NDs), but also effectively promotes the proliferation of mammalian cells. Under the synergy of multiple mechanisms, G@CuS eradicated the colonized bacteria in the wound of mice infected with Staphylococcus aureus (S. aureus) and accelerated wound healing. The proposed application strategy of nanogel is expected to provide a new idea for clinical transformation. Full article

(This article belongs to the Special Issue Recent Advances on Nanogel Engineering for Drug Delivery)

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18 pages, 3497 KiB

Open AccessArticle

Synthesis and Characterization of Acrylamide/Acrylic Acid Co-Polymers and Glutaraldehyde Crosslinked pH-Sensitive Hydrogels

by Munir Ahmad Khan, Abul Kalam Azad, Muhammad Safdar, Asif Nawaz, Muhammad Akhlaq, Pijush Paul, Md. Kamal Hossain, Md. Habibur Rahman, Roua S. Baty, Attalla F. El-kott, Mohamed Kamel, Simona G. Bungau and Mohamed M. Abdel-Daim

Gels 2022, 8(1), 47; https://0-doi-org.brum.beds.ac.uk/10.3390/gels8010047 - 09 Jan 2022

Cited by 17 | Viewed by 3968

Abstract

This project aims to synthesize and characterize the pH-sensitive controlled release of 5-fluorouracil (5-FU) loaded hydrogels (5-FULH) by polymerization of acrylamide (AM) and acrylic acid (AA) in the presence of glutaraldehyde (GA) as a crosslinker with ammonium persulphate as an initiator. The formulation’s code is named according to acrylamide (A1, A2, A3), acrylic acid (B1, B2, B3) and glutaraldehyde (C1, C2, C3). The optimized formulations were exposed to various physicochemical tests, namely swelling, diffusion, porosity, sol gel analysis, and attenuated total reflection-Fourier transform infrared (ATR-FTIR). These 5-FULH were subjected to kinetic models for drug release data. The 5-FU were shown to be soluble in distilled water and phosphate buffer media at pH 7.4, and sparingly soluble in an acidic media at pH 1.2. The ATR-FTIR data confirmed that the 5-FU have no interaction with other ingredients. The lowest dynamic (0.98 ± 0.04% to 1.90 ± 0.03%; 1.65 ± 0.01% to 6.88 ± 0.03%) and equilibrium swelling (1.85 ± 0.01% to 6.68 ± 0.03%; 10.12 ± 0.02% to 27.89 ± 0.03%) of formulations was observed at pH 1.2, whereas the higher dynamic (4.33 ± 0.04% to 10.21 ± 0.01%) and equilibrium swelling (22.25 ± 0.03% to 55.48 ± 0.04%) was recorded at pH 7.4. These findings clearly indicated that the synthesized 5-FULH have potential swelling characteristics in pH 6.8 that will enhance the drug’s release in the same pH medium. The porosity values of formulated 5-FULH range from 34% to 62% with different weight ratios of AM, AA, and GA. The gel fractions data showed variations ranging from 74 ± 0.4% (A1) to 94 ± 0.2% (B3). However, formulation A1 reported the highest 24 ± 0.1% and B3 the lowest 09 ± 0.3% sol fractions rate among the formulations. Around 20% drug release from the 5-FULH was found at 1 h in an acidic media (pH1.2), whereas >65% of drug release (pH7.4) was observed at around 25 h. These findings concluded that GA crosslinked 5-FU loaded AM and AA based hydrogels would be a potential pH-sensitive oral controlled colon drug delivery carrier. Full article

(This article belongs to the Special Issue Recent Advances on Nanogel Engineering for Drug Delivery)

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Review

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23 pages, 1097 KiB

Open AccessReview

Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications

by Rakesh K. Sindhu, Rubal Gupta, Gaurish Wadhera and Pradeep Kumar

Gels 2022, 8(2), 97; https://0-doi-org.brum.beds.ac.uk/10.3390/gels8020097 - 07 Feb 2022

Cited by 25 | Viewed by 4628

Abstract

This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation. Full article

(This article belongs to the Special Issue Recent Advances on Nanogel Engineering for Drug Delivery)

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