Special Issue "Genetics and Epigenetics of Allergy Diseases"
Deadline for manuscript submissions: 1 March 2022.
Interests: genetics; epigenetics; allergy; gene regulation; pharmacogenomics
Interests: molecular mechanisms of allergic diseases; molecular; human biology; medical genetics; regulation of gene expression; epigenetics
Allergic diseases are a clear example of complex multifactorial diseases mediated by the interaction of different genetic and epigenetic factors. Whole genome sequencing studies and polygenic risk score analyses in well-characterized homogeneous populations have provided a wealth of information on many susceptibility genes. However, many gene associations have not been able to be replicated, and functional studies on the mechanisms that mediate these diseases are still scarce. In this sense, epigenetic factors provide additional information that could explain not only the discrepancies observed between monozygotic twins but also phenomena such as incomplete penetrance, variable expression, gender and progenitor effects, and the progressive increase in the prevalence of allergic diseases observed during the last few decades. Different studies have shown a connection between disease susceptibility and environmental exposure during intrauterine life or early childhood, potentially mediated by epigenetic modifications. In response to an environmental challenge, epigenetic modifications allow an adaptive change that modifies gene expression and leads to the triggering of allergic diseases. In this Special Issue, different genetic and epigenetic factors involved in the development of allergic diseases will be considered.
Prof. Dr. Catalina Sanz
Dr. Asunción García-Sánchez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genetics of allergy
- gene functional studies in allergy
- epigenetic modifications in allergy
- pharmacogenetics in allergy
- gene therapies in allergy
- interactions between genes and environment in allergies