Epigenetic Control of B-Cell Lymphomagenesis and Response to Therapy

Dear Colleagues,

The term B-cell lymphoma encompasses different neoplasms characterized by an abnormal proliferation of lymphoid cells at various stages of differentiation. B-cell lymphoma develops more frequently in older adults and immunocompromised individuals and includes both Hodgkin’s lymphomas (HLs) and most B-cell non-Hodgkin lymphomas (B-NHLs). Thanks to the recent advances in deep sequencing, it has become apparent that mutations affecting histone methyltransferases, histone demethylases, histone acetyltransferases, and consequent disturbance of epigenomic patterning are frequent events in most B-cell lymphomas.

In this Special Issue, we welcome both review articles and original research aimed at highlighting these new findings and providing a conceptual framework for understanding how epigenetic lesions contribute to lymphomagenesis and to response to therapy. We look forward to your contribution.

Dr. Gael Roue
Guest Editor

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• Non-Hodgkin lymphoma
• Epigenetics
• DNA methylation
• HAT
• HDAC
• EZH2
• Bromodomain inhibitors
• Drug combination
• Clinical testing