Special Issue "Cardiovascular Disease Risk Factors, Genetics, and Prevention"
Deadline for manuscript submissions: closed (1 October 2021).
Interests: cardiovascular diseases; molecular mechanisms; genetics; mitochondria; natriuretic peptides
Cardiovascular diseases (CVDs) still represent a major health issue causing a heavy burden on national health systems. New preventive and therapeutic strategies are needed to reduce the socioeconomic impact of CVDs. Knowledge gained over the last decades, through experimental, clinical, and epidemiological approaches, has revealed the existence of multiple risk factors, including both genetic and environmental factors, concurring to the predisposition to develop CVDs. The study of many genetically modified animal models has allowed the discovery of distinct genes underlying CVDs development along with their molecular mechanisms of action, with frequent translation to the human condition. Thus, we know that specific genes may modulate—when either differentially expressed or mutated—the individual predisposition to develop either monogenic or polygenic forms of CVDs. Their interaction with environmental factors is critical to explaining the resulting pathological phenotypes. Importantly, based on the current knowledge, new preventive and therapeutic strategies can be designed to reduce the impact of CVDs.
This Special Issue will comprise reviews and original research articles focused on the recent advances of genetics/genomics and epigenetic mechanisms involved in CVD pathogenesis. Current and future directions, with particular focus on improved prevention of CVDs, particularly based on genetic acquisition, will be considered.
Prof. Speranza Rubattu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Cardiovascular disease risk factors
- Gene variants
- Dietary factors
- Animal models