Integrative Multi-Omics and Single-Cell Approaches to Study Complex Diseases

Dear Colleagues,

We are reaching out to request your participation in our Special Issue: “Integrative multiMulti-Omics and Single-Cell Approaches to Study Complex Diseases” in Genes.

Recent advances in genomic sequencing technologies have led to an explosion in multi-omics datasets (e.g., genomics, transcriptomics, epigenomics, metabolomics, proteomics, microbiomics, etc.), which has been accompanied by the development of novel computational genomics tools to analyse these data and perform integrative analysis. Together, these approaches have rapidly expanded the number of discoveries for complex diseases, such as  cancer, cardiometabolic disease, neurological diseases, and immune diseases. Many of these new methods have been adapted to the single-cell level, which has revealed new challenges to overcome related to data heterogeneity, signal-to-noise, sparsity, scalability, and validation.

In this Special Issue, we hope to bring together experts in genomics from multi-disciplinary backgrounds to share their collective expertise in a broad range of topics related to multi-omics data integration for various complex human diseases. We expect the themes to cover various topics, such as bulk and single-cell multi-omics and multi-modal data acquisition and analyses (e.g., scRNA-seq and scATAC-seq), other epigenomic profiling and proteomics methods, spatial transcriptomics, data harmonization and normalization methods, quantitative trait locus mapping methods, development of user-friendly pipelines for end-to-end analysis, web platforms for sharing and visualizing datasets, as well as challenges with computational scalability, cost, benchmarking and validation. We welcome applications to a broad range of cell/tissue and disease areas, involving either publicly available or custom datasets. We also welcome multiple manuscript formats, including original research articles, reviews or mini-reviews, opinions, hypotheses, or theories.

Dr. Clint L. Miller
Prof. Dr. Xia Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• complex diseases
• cardiovascular diseases
• genome-wide association studies
• multi-omics analysis
• computational systems biology
• single-cell analysis