Special Issue "Regulating Gene Activity By Sequestering Transcriptional Regulators"
Deadline for manuscript submissions: closed (1 March 2021).
Interests: development; evolution; drosophila; notch signaling pathway; cell–cell communication
In eukaryotes, gene transcription occurs within the nucleus. Accordingly, transcriptional regulators must enter the nuclear compartment. Numerous regulatory mechanisms guard the nuclear import or export of transcriptional regulators or their co-factors. Sequestering transcriptional regulators in a specific subcellular compartment is one mechanism to control their availability. Prime examples are the regulation of NF-κB nuclear entry by IκB, the cytoplasmic anchoring of cleaved Ci/Gli during Hedgehog signalling or of ß-Cat during Wnt signaling, as well as the co-import of RBPJ (or CBF1) by co-repressors and co-activators during Notch signaling. These examples represent a small sample of transcription factors, where nuclear entry is tightly controlled. Not surprisingly, the factors guarding nuclear import or export are themselves subjected to a dose-sensitive regulation.
This Special Issue will focus on the sequestering of transcriptional regulators for experimental or therapeutic intervention, including specific techniques to abrogate the function of nuclear proteins in a reversible manner. We invite submissions of reviews, research articles, and short communications on related topics by 1 March 2021.
Dr. Dieter Maier
Dr. Anja Nagel
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Gene regulation
- Transcriptional regulation
- Transcription complexes