Genetics of Hearing Impairment
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (1 November 2020) | Viewed by 64336
Special Issue Editors
2. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain
Interests: inherited hearing impairment; gene identification; spectra of mutations; mechanisms of pathogenesis; auditory phenotypes; physiology of the inner ear; mouse models; gene therapy
Interests: inherited hearing impairment; gene identification; spectra of mutations; mechanisms of pathogenesis; auditory phenotypes; physiology of the inner ear; mouse models; gene therapy
Special Issue Information
Dear Colleagues,
The inner ear is a complex machinery at the cellular and molecular levels. Many different genes and proteins play roles in the development and maintenance of its structure and function through participating in diverse molecular networks. A defect in any of these components can result in hearing impairment. Consequently, hearing impairment encompasses a wide variety of disorders that are clinically and genetically heterogeneous. Understanding their genetic causes and their pathophysiological mechanisms, and characterizing the resulting phenotypes, are essential for developing novel therapies that target the specific defects. Application of the most recent omics technologies and genome editing methods is boosting the research in this field. This Special Issue in Genes entitled “Genetics of Hearing Impairment” will address the genes and mutations involved in hearing impairment, the mechanisms through which mutations result in the different syndromic or non-syndromic disorders, the description of the associated phenotypes in humans and in animal models, and the development of specific gene therapies.
Dr. Ignacio del Castillo
Prof. Hannie Kremer
Guest Editors
Manuscript Submission Information
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Keywords
- Inner ear
- Hearing impairment
- Gene identification
- Disease-causing mutations
- Genetic epidemiology
- Genotype-phenotype correlations
- Pathophysiological mechanisms
- Omics
- Genome editing
- Gene therapy