Dear Colleagues,

Immunity is an integral part of mammalian defense against infection. The innate and acquired immunity work hand in hand to achieve optimal defense. The development and differentiation of each cells playing role in this process are genetically tightly regulated. Recent studies have demonstrated that epigenetics play a significant role in the regulation of these genes, including development of specific B and T cells. The inherent aberration of this regulation, naturally or after infection results in many types of pathological conditions including inflammation and autoimmune diseases. Tumor development is a multi-step process which involves many different mechanisms. The current dogma states that cancer progression involves accumulation of mutations. When this process possibly play important role in cancer progression, recently it is hypothesized that initiation and formation of cancer progenitor cells is possibly an epigenetic event. Another important aspect of tumor development which is of much attention is the inflammation. Check point molecules help tumors escape immune surveillance but the regulation is still unknown. Recent studies warrant more comprehensive investigation on these topics and this special issue is open to articles on these emerging areas of research.

Dr. Sibaji Sarkar
Guest Editor

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• cancer
• epigenetics
• histone modification
• methylation
• genomics
• immunology
• autoimmune disease
• infection
• inflammation
• check point inhibitors
• cancer drug resistance
• combination therapy