Genomics and Models of Nerve Sheath Tumors
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 41654
Special Issue Editors
Interests: genomics and mouse models of MPNST
Interests: NF1; RAS signaling; MPNST; rhabdomyosarcoma
Special Issues, Collections and Topics in MDPI journals
Interests: tumor microenvironment and mouse models of sarcoma
Special Issue Information
Dear Colleagues,
Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma, malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically, as well as in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors, will ultimately lead to therapies that result in better outcomes.
In this Special Issue, we welcome both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors. This Special Issue will also focus on genomic methods being developed and applied to advance our understanding of these tumors. We aim for the edition to emphasize the ability of genomic knowledge to translate to advances in management of patients affected by these tumors. We look forward to your contribution.
Prof. Angela C. HirbeProf. Christine A. Pratilas
Prof. Rebecca D. Dodd
Guest Editors
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Keywords
- Plexiform neurofibroma
- Atypical neurofibroma
- MPNST
- Schwannoma
- Mouse models
- Genomics