Method Development for Pan-Genome Research on Microbes

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 4816

Special Issue Editor

School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: pan-genome; metagenome; evolution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

With the advance of microbiome research, more and more previously unknown species have been realized by researchers worldwide, together with their genome sequences. These species and genomes have constituted a grand pool of new resources for a better understanding of the evolution and ecology patterns of microbes, including virus, bacteria, archaea, fungi, and protists. Faced with the paramount number of species and their accompanying omics data, new tools are also needed. In this Special Issue on “Method Development for Pan-Genome Research on Microbes”, we welcome works that focus on novel methods for mining evolution and ecology patterns of microbes from both pan-genome and metagenome.

Prof. Dr. Kang Ning
Guest Editor

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Keywords

  • pan-genome
  • metagenome
  • evolution
  • ecology
  • method development

Published Papers (1 paper)

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Review

19 pages, 2355 KiB  
Review
Pangenomics in Microbial and Crop Research: Progress, Applications, and Perspectives
by Sumit Kumar Aggarwal, Alla Singh, Mukesh Choudhary, Aundy Kumar, Sujay Rakshit, Pardeep Kumar, Abhishek Bohra and Rajeev K. Varshney
Genes 2022, 13(4), 598; https://0-doi-org.brum.beds.ac.uk/10.3390/genes13040598 - 27 Mar 2022
Cited by 6 | Viewed by 4410
Abstract
Advances in sequencing technologies and bioinformatics tools have fueled a renewed interest in whole genome sequencing efforts in many organisms. The growing availability of multiple genome sequences has advanced our understanding of the within-species diversity, in the form of a pangenome. Pangenomics has [...] Read more.
Advances in sequencing technologies and bioinformatics tools have fueled a renewed interest in whole genome sequencing efforts in many organisms. The growing availability of multiple genome sequences has advanced our understanding of the within-species diversity, in the form of a pangenome. Pangenomics has opened new avenues for future research such as allowing dissection of complex molecular mechanisms and increased confidence in genome mapping. To comprehensively capture the genetic diversity for improving plant performance, the pangenome concept is further extended from species to genus level by the inclusion of wild species, constituting a super-pangenome. Characterization of pangenome has implications for both basic and applied research. The concept of pangenome has transformed the way biological questions are addressed. From understanding evolution and adaptation to elucidating host–pathogen interactions, finding novel genes or breeding targets to aid crop improvement to design effective vaccines for human prophylaxis, the increasing availability of the pangenome has revolutionized several aspects of biological research. The future availability of high-resolution pangenomes based on reference-level near-complete genome assemblies would greatly improve our ability to address complex biological problems. Full article
(This article belongs to the Special Issue Method Development for Pan-Genome Research on Microbes)
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