Special Issue "Proteins: Proteomics and Beyond"
Deadline for manuscript submissions: 20 October 2021.
Interests: protein evolution; protein engineering; structure-function; evolutionary biochemistry; hemoglobin
Interests: high throughput proteomics; fusion genes; bioinformatics; cancer genetics; diagnostic protein markers; personalized medicine
Recent technological advancements in mass spectrometry-based high-throughput proteomics have redefined the biomedical sciences and have played a key role in understanding human diseases. Proteins are the molecules that dictate the structure, function, metabolism, and signaling events in the cells. They also play a crucial role in prognosis, diagnosis, and drug responsiveness to a disease. Though cost-effective genome sequencing technologies have revolutionized and contributed efficiently towards discovering the novel biological processes, they alone do not capture these processes in their entirety. For example, despite the rapid detection of mutations in protein-coding genes, the impact of these mutations on the protein structure, function, and interacting protein partners or ligands has not been studied at a comparable pace.
The exponential advancements in high-throughput technologies complemented by advanced bioinformatics tools have resulted in a shift of paradigm from studying individual genes or proteins to the global “omics” discipline. While errors in proteins are a major cause of diseases, proteins can also cure diseases, since they serve as the most promising target for drugs to date. The roles they play in the disease-specific cellular circuitry cannot be exclusively attributed to the primary structure but are also impacted by spatio-temporal expression changes, folding, post-translational modifications, protein-protein, protein-DNA, and protein-ligand interactions, which can be deciphered with the help of proteomic tools. In turn, this has helped us unravel the dynamic processes of origin of diseases, thereby supporting early detection, classification, prognosis, diagnosis, and the development of personalized therapeutic combinations based on resistance and toxicity.
In this special issue of Genes on “Proteins: Proteomics and Beyond” we aim to compile a series of original and review articles focusing on experimental and theoretical approaches addressing the structure-function relationship, proteins or proteomic profiles in various biological systems, protein evolution, protein engineering and designs, molecular interactions (protein-protein or protein-ligand), protein folding, post-translational modification (PTM), and protein biomarkers.
Dr. Chandrasekhar Natarajan
Dr. Neetha Nanoth Vellichirammal
Dr. Nishana Mayilaadumveettil
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- protein evolution
- protein complexes
- protein engineering
- diagnostic protein markers
- protein variations
- post-translational modification