Regulation of Gene Expression: RNA Modification of Genes
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 April 2022) | Viewed by 6085
Special Issue Editors
Interests: RNA modification; RNA processing; RNA binding proteins; transcriptional regulation; functional genomics
Special Issue Information
Dear Colleagues,
More than 100 types of RNA modifications have been identified in both mRNA and non-coding RNAs, including adenosine-to-inosine RNA editing, N6-methyladenosine (m6A), and 5-methycytosine (m5C), to name just a few. With the development of various genome-wide sequencing technologies for detecting RNA modifications and the discovery of writers, erasers and readers in the last decade, RNA modifications have been increasingly appreciated as key players in regulating gene expression programs. In response to both internal and external stimuli, RNA modifications confer cell a tunable mechanism to regulate transcription, RNA metabolism and translation. However, our understanding of the regulatory mechanisms remains incomplete. Extensive efforts are needed to develop novel tools for detecting RNA modifications at a single-base resolution and in a quantitative manner, to characterize key binding proteins of RNA modifications for elucidating the regulatory network, and to understand how the dysregulation of RNA modifications might contribute to disorders and diseases.
The present Special Issue is expected to present technical advances and mechanistic studies towards a better understanding of gene expression regulation by RNA modifications. We welcome both reviews and original research articles. For further information about the scope of this Special Issue and preferred manuscript topics, please feel free to contact the Guest Editors.
Dr. Jia-Yu Chen
Dr. Xiaoyu Li
Guest Editors
Manuscript Submission Information
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