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Satellite DNAs: From Cellular Functions to Diseases
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Satellite DNAs: From Cellular Functions to Diseases

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (15 April 2021) | Viewed by 3781

Special Issue Editor

Dr. Isidoro Feliciello

E-Mail Website
Guest Editor
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80100 Napoli, Italy
Interests: mobilome; satellite DNA; heterochromatin; evolution; gene regulation; satellite RNA; epigenetics; DNA repair
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Satellite DNAs contribute significantly to form the genome architecture of every eukaryote. The mechanism about the origin, evolution and maintenance of satellite DNA is still poorly understood but certainly this highly repetitive non-coding DNA has a role in vital cellular functions and evolutionary processes.
The main aim of the proposed Special Issue in Genes on “Satellite DNAs: from cellular functions to diseases” is to underline the role that genetic or epigenetic alteration of satellite DNAs could play in diseases. We hope this Special Issue will contribute to stimulate extensive research on the involvement of satellite DNAs in causal association with diseases.
I would like to invite you to contribute principally a research paper in your area of expertise. Exceptionally, review paper is welcome in the case of a forward-thinking view on upcoming challenges.

Thanks.
Best regards,

Dr. Isidoro Feliciello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Satellite DNA;
  • Chromosomal Instability;
  • Cancer;
  • Circulating Cell-Free DNA;
  • Non-coding RNA;
  • Stress.

Published Papers (1 paper)

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Research

17 pages, 2779 KiB  
Article
Satellite DNA in Neotropical Deer Species
by Miluse Vozdova, Svatava Kubickova, Natália Martínková, David Javier Galindo, Agda Maria Bernegossi, Halina Cernohorska, Dita Kadlcikova, Petra Musilová, Jose Mauricio Duarte and Jiri Rubes
Genes 2021, 12(1), 123; https://0-doi-org.brum.beds.ac.uk/10.3390/genes12010123 - 19 Jan 2021
Cited by 8 | Viewed by 3279
Abstract
The taxonomy and phylogenetics of Neotropical deer have been mostly based on morphological criteria and needs a critical revision on the basis of new molecular and cytogenetic markers. In this study, we used the variation in the sequence, copy number, and chromosome localization [...] Read more.
The taxonomy and phylogenetics of Neotropical deer have been mostly based on morphological criteria and needs a critical revision on the basis of new molecular and cytogenetic markers. In this study, we used the variation in the sequence, copy number, and chromosome localization of satellite I-IV DNA to evaluate evolutionary relationships among eight Neotropical deer species. Using FISH with satI-IV probes derived from Mazama gouazoubira, we proved the presence of satellite DNA blocks in peri/centromeric regions of all analyzed deer. Satellite DNA was also detected in the interstitial chromosome regions of species of the genus Mazama with highly reduced chromosome numbers. In contrast to Blastocerus dichotomus, Ozotoceros bezoarticus, and Odocoileus virginianus, Mazama species showed high abundance of satIV DNA by FISH. The phylogenetic analysis of the satellite DNA showed close relationships between O. bezoarticus and B. dichotomus. Furthermore, the Neotropical and Nearctic populations of O. virginianus formed a single clade. However, the satellite DNA phylogeny did not allow resolving the relationships within the genus Mazama. The high abundance of the satellite DNA in centromeres probably contributes to the formation of chromosomal rearrangements, thus leading to a fast and ongoing speciation in this genus, which has not yet been reflected in the satellite DNA sequence diversification. Full article
(This article belongs to the Special Issue Satellite DNAs: From Cellular Functions to Diseases)
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