Special Issue "The Stress Response in Microorganisms"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: 10 February 2022.

Special Issue Editor

Dr. Jose M. Requena
E-Mail Website1 Website2
Guest Editor
Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, 28049 Madrid, Spain
Interests: Leishmania; Trypanosoma; heat shock proteins; RNA binding proteins; regulation of gene expression; genomics; transcriptomics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues, 

Organisms cope with environmental changes that often represent stress situations, including elevated temperatures, chemical stress or oxidative injury. Cells need to counteract those stressful stimuli through coordinated changes in gene expression leading to the synthesis of specialized molecules. This response, known as the stress response, is universal, being found in every living form, from bacteria to mammalian cells. Given their relative cellular simplicity, bacteria and eukaryotic microorganisms are very useful for studying the stress response and its regulation. Moreover, among them, pathogenic microorganisms are subjected to sudden environmental challenges throughout their life cycle, including large changes in temperature, availability of nutrients and exposure to host immune defenses. Thus, pathogenic microorganisms have integrated the stress response into their life cycles, in which stress signaling pathways and the stress proteins also play specific functions in their differentiation program.

The aim of this Special Issue is to provide the state of the art on the proteins and molecular mechanisms involved in the stress response in unicellular organisms: bacteria, yeast and protists. More precisely, articles focusing on stress proteins, changes in gene expression associated with stressful conditions (including antibiotic and drug resistance), damage–repair proteins, and metabolic changes in response to stress, among others, are welcome.

Dr. Jose M. Requena
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • heat shock proteins and genes
  • stress response molecular mechanisms
  • bacteria
  • yeast
  • protists
  • unicellular pathogens

Published Papers

This special issue is now open for submission.
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