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Advances in Tumor Epigenetics Research
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Advances in Tumor Epigenetics Research

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (26 April 2021) | Viewed by 6745

Special Issue Editor

Dr. Andrea Piunti

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611, USA
Interests: molecular biology; cancer biology; gene regulation; gene expression; chromatin; genomics; RNA; DNA

Special Issue Information

Dear Colleagues,

The notion that genetic alterations are not the only underlying cause of cancer formation and progression has been increasingly supported in the recently published literature. Among epigenetics alterations, chromatin deregulation is arguably one of the main contributing factors that promote cancer. It is therefore not surprising that an increasing number of cancers present with recurrent chromatin aberrations that are sometimes even demonstrated by recurrent genetic mutations at multiple chromatin machinery genes. Efforts aimed to develop potential therapies to target or take advantage of chromatin alterations are currently under development. This Special Issue will highlight the molecular basis of cancers with highly deregulated chromatin dynamics as well as the efforts to develop chromatin-related therapeutics.

Dr. Andrea Piunti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chromatin
  • Cancer epigenetics
  • Chromatin therapeutics
  • Gene regulation
  • Gene mutations.

Published Papers (2 papers)

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Research

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17 pages, 8376 KiB  
Article
Identification of Differentially Methylated Regions Associated with a Knockout of SUV39H1 in Prostate Cancer Cells
by Wenbo Yan, Yuqi Guo, Fangxi Xu, Deepak Saxena and Xin Li
Genes 2020, 11(10), 1188; https://0-doi-org.brum.beds.ac.uk/10.3390/genes11101188 - 13 Oct 2020
Cited by 2 | Viewed by 2018
Abstract
Epigenetic alterations, such as histone methylations, affect the pathogenesis of tumors including prostate cancer (PCa). Previously, we reported that metformin reduced SUV39H1, a histone methyltransferase of H3 Lys9, to inhibit the migration of PCa cells. Since histone methylation is functionally linked to DNA [...] Read more.
Epigenetic alterations, such as histone methylations, affect the pathogenesis of tumors including prostate cancer (PCa). Previously, we reported that metformin reduced SUV39H1, a histone methyltransferase of H3 Lys9, to inhibit the migration of PCa cells. Since histone methylation is functionally linked to DNA methylation, we speculate that the knockout of the SUV39H1 gene will affect the genomic DNA methylation profile to regulate PCa cell migration and invasion. The genome-wide DNA methylation level is lower in SUV39H1 knockout (KO) cells than wild-type (WT) ones. However, the methylation levels in functional regions of CpG Islands (CGI), 5′ untranslated region (UTR5), and exon regions are higher in KO cells than WT cells. Analysis of differentially methylated regions (DMRs) identified 1241 DMR genes that have differential methylation on CG sites when comparing the KO and WT samples. Gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes Pathways analysis showed that knockout of SUV39H1 affects gene sets and pathways that are heavily involved in cell shapes, cell recognition, adhesion, motility, and migration. Our study suggests that SUV39H1 plays an important role in PCa migration via the epigenetic regulation of methylation on CG sites, and is a novel and legitimate target to inhibit PCa cell migration. Full article
(This article belongs to the Special Issue Advances in Tumor Epigenetics Research)
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Review

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16 pages, 1546 KiB  
Review
The PARP Way to Epigenetic Changes
by Simone Ummarino, Clinton Hausman and Annalisa Di Ruscio
Genes 2021, 12(3), 446; https://0-doi-org.brum.beds.ac.uk/10.3390/genes12030446 - 20 Mar 2021
Cited by 23 | Viewed by 4337
Abstract
ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. This reaction known as PARylation modulates essential cellular [...] Read more.
ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from “nicotinamide adenine dinucleotide-donor molecules” to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond. Full article
(This article belongs to the Special Issue Advances in Tumor Epigenetics Research)
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