Special Issue "Deciphering Epigenetic Signature in Human Health and Disease"
Deadline for manuscript submissions: 5 November 2021.
Interests: DNA methylation; chromatin dynamics; epigenetics; stem cell regulation; cancer
Epigenetic modifications, including DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs, represent the regulatory network at the basis of development and differentiation. The fundamental role in gene expression puts epigenetics at the head of many diseases related to both development and cancer progression.
DNA methylation is the first mechanism that decides the fate of cells and the entire development of organisms; for this reason, aberrant methylation is a cause of altered development and is liable for tumors and several diseases. In recent years, the methylation signature has been the focus of numerous studies for the early diagnosis of diseases, given the advantage of being able to detect DNA methylation through free circulating DNA analysis. On the other hand, chromatin dynamics and the microRNA expression are directly responsible for many functions, including gene regulation, genome replication, and maintenance. The genome and epigenome in single-cell sequencing have enabled deciphering some of the epigenetic codes underlying both development and severe diseases. Today, epigenetics is still at the center of numerous studies, including those based on epigenetic drugs used for malignant phenotype reversion.
The aim of this Special Issue is to provide a broad overview of the topic of epigenetic signatures that mark development and cells differentiation. It will also discuss the correlation between epigenetics and inflammation, genetic disease, and cancer. Finally, it will give attention to the genomic distribution of DNA methylation at high resolution in various organisms, cell types, and diseases.
Dr. Tiziana Angrisano
Dr. Michele Longo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA methylation
- Chromatin dynamics
- Stem cell regulation
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Tentative title: Association study of SLC6A4 (5-HTTLPR) polymorphism and its promoter methylation with rehabilitation outcome in patients with Subacute Stroke
Tentative title: Analysis of syntenic X-chromosome genes implicated in neurodevelopmental diseases revealed a convergent expression profiles in human and mouse brain