Special Issue "Frontiers in Genetics and Genomics of Ovarian Cancer"
Deadline for manuscript submissions: 15 December 2021.
2. Department of Biomedical Science, Colledge of Life Science, CHA University, Sungnam-si, Gyeonggi-do, Korea
Interests: high-grade serous ovarian carcinoma; genome instability; DNA damage repair; cellular senescence; homologous recombination deficiency; 3D chromosomal organization
Ovarian cancer is a leading cause of death among patients with gynecological malignancies and the majority of ovarian cancer cases are high-grade serous carcinomas (HGSCs). Current estimates indicated that women with germline mutations in BRCA1 or BRCA2 have a 30% to 70% chance of developing ovarian cancer and TP53 mutation is clearly an early event in developing HGSCs. The Cancer Genome Atlas (TCGA) also reported that mutations in TP53 are present in more than 96% of HGSCs and homologous recombination (HR) deficiency (e.g. BRCA1 or BRCA2) is present in approximately 50% of the patients. This means that the other half of HGSCs have no apparent defect in HR. Moreover, HGSC is one of the most chromosamally variant malignancies (i.e., genome instability). CCNE1 amplification, RB1 loss and NF1 loss are frequently observed in HGSC.
In this era of targeted therapy, to reduce incidence and improve outcomes in HGSC, precise molecular characterization of HGSC from individual patients is very important. We need to understand the genetics and genomics of HGSC in a holistic way by considering several molecular pathways such as HR deficiency, P53 aberration, DNA damage repair, cellular senescence, immune evasion, DNA replication stress, genome instability and its epigenetic regulation. We also hope that 3D chromosome organization will provide new insights into the molecular mechanism of its chromosomal aberration and help in the identification of its new therapeutic targets.
In this Special Issue of Genes on “Genetics and Genomics of Ovarian Cancer”, we welcome reviews, mini-reviews, new methods, and original research articles that advance our understanding of ovarian cancers. While the new insights driven by 3D chromosome organization on molecular mechanisms or pathways related to HGSC—such as P53 aberration, cellular senescence, immune evasion, and genome instability—will be of special interest, we will also be open to any topic that advances the understanding of ovarian cancers to develop a better therapeutic method.
Dr. Sohyun Hwang
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- high-grade serous ovarian carcinoma
- genome instability
- homologous recombination deficiency
- P53 aberration
- DNA damage repair
- cellular senescence
- PARP inhibitor
- DNA replication stress
- epigenetic regulation
- 3D genome