Dear Colleagues,

Calcium and phosphorus are among the most abundant mineral elements of the human body and are tightly regulated by a homeostasis which is as subtle as it is complex. Nevertheless, Ca and P inherited disorders still represent an underestimated niche of human diseases due to the difficulties associated with a prompt and effective diagnosis, as reflected in the challenges faced in patient management.

Although the recent achievements in the NGS era allowed the identification of some genetic triggers of the Ca/P metabolism, their exact role in the actual pathophysiology remains elusive.

This Special Issue of Genes aims to better focus on genetic and genomics determinants that could influence the subtle balance at the base of Ca and P homeostasis. Thus, unpublished manuscripts (research articles, reviews, and communications) on the NGS approach, as well as functional studies on old and novel genetic players, describing basic, translational, and clinical insights, are encouraged, with particular interest in primary hyperparathyroidism (and endophenotypes, such as FIHP, FHH, HPT-JT, MEN1), hypophosphatemia, hypophosphatasia, and other related disorders.

Dr. Vito Guarnieri
Dr. Maurizio Delvecchio
Dr. Chiara Verdelli
Dr. Orazio Palumbo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• next-generation sequencing
• genetics
• metabolism
• metabolic disorders
• primary hyperparathyroidism
• hypophosphatemia
• hypophosphatasia