Shared Mechanisms and Multimorbidity for Immune-Mediated Diseases

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (16 October 2020) | Viewed by 6024

Special Issue Editor

Wellcome Centre for Human Genetics, University of Oxford
Interests: genetic variability; autoimmune diseases

Special Issue Information

Dear colleagues,

Immune-mediated diseases (IMDs) currently affect approximately 10% of the global population and are increasing in incidence. These diseases are typically chronic, multifactorial conditions with no cure, and they therefore pose a substantial burden for affected individuals, their families, and the healthcare system. However, understanding the biological pathways that are common to different IMDs and their co-morbid clinical phenotypes can aid the development of strategies for the improvement treatment and management of multiple conditions.

This Special Issue will highlight recent advances in genetics and functional genomics that are facilitating the determination of pathophysiological mechanisms that are shared across multiple IMDs and that drive co-morbidity between IMDs and with other disorders. These advances include the development of new approaches for investigating cross-trait associations; the utilization of big data sets; and the implementation of high-throughput, high-resolution methods for patient immunoprofiling, including single-cell genomics. We welcome the submission of reviews, perspectives, short communications, and research articles.

Dr. Calliope Dendrou
Guest Editor

Manuscript Submission Information

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Keywords

  • Immune-mediated disease
  • Autoimmunity
  • Shared mechanisms
  • Multimorbidity
  • Immunoprofiling
  • Cross-trait associations
  • Big data
  • Population-based cohorts
  • Electronic health records
  • Single-cell genomics

Published Papers (2 papers)

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Review

13 pages, 521 KiB  
Review
Approaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomics
by David González-Serna, Gonzalo Villanueva-Martin, Marialbert Acosta-Herrera, Ana Márquez and Javier Martín
Genes 2020, 11(12), 1482; https://0-doi-org.brum.beds.ac.uk/10.3390/genes11121482 - 09 Dec 2020
Cited by 6 | Viewed by 2255
Abstract
Immune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by environmental and genetic factors. Associations between genetic loci and susceptibility to these diseases have been widely studied, and hundreds of risk variants have emerged during the last two decades, with researchers observing [...] Read more.
Immune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by environmental and genetic factors. Associations between genetic loci and susceptibility to these diseases have been widely studied, and hundreds of risk variants have emerged during the last two decades, with researchers observing a shared genetic pattern among them. Nevertheless, the pathological mechanism behind these associations remains a challenge that has just started to be understood thanks to functional genomic approaches. Transcriptomics, regulatory elements, chromatin interactome, as well as the experimental characterization of genomic findings, constitute key elements in the emerging understandings of how genetics affects the etiopathogenesis of IMDs. In this review, we will focus on the latest advances in the field of functional genomics, centering our attention on systemic rheumatic IMDs. Full article
(This article belongs to the Special Issue Shared Mechanisms and Multimorbidity for Immune-Mediated Diseases)
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15 pages, 683 KiB  
Review
Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis
by Guoying Wang, Xianghui Li, Lei Zhang, Abualgasim Elgaili Abdalla, Tieshan Teng and Yanzhang Li
Genes 2020, 11(3), 323; https://0-doi-org.brum.beds.ac.uk/10.3390/genes11030323 - 18 Mar 2020
Cited by 6 | Viewed by 3431
Abstract
Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the [...] Read more.
Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the role of DCs in the progression of sepsis and we also discuss the reverse sepsis-induced immunosuppression through manipulating the DC function. In addition, we highlight some potent immunotherapies that could be used as a novel strategy in the early treatment of sepsis. Full article
(This article belongs to the Special Issue Shared Mechanisms and Multimorbidity for Immune-Mediated Diseases)
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