Special Issue "Mendelian Randomization Studies in Cardiometabolic Diseases"
Deadline for manuscript submissions: 15 January 2022.
Interests: genetic polymorphism; association analysis; molecular cardiology; molecular nephrology; pharmacogenetics; monogenic diseases
Interests: high-throughput genomics; metabolomics; cardiovascular traits; drug response
Interests: molecular mechanism of cancer formation
The burgeoning list of genome-wide association studies, biobanks and deeply phenotyped and genotyped population cohorts has led to advances in methods to infer causality from genomic data. The random allocation of genetic variants at conception means that their associations with clinical traits are relatively devoid of the confounding factors that can hinder causal inference in traditional epidemiological studies. Provided those genetic variants related to an exposure affect an outcome through that exposure and not a pleiotropic pathway, these genetic variants can be leveraged as instruments for exploring causal effects of the exposure on the outcome in an approach termed ‘Mendelian randomization’. This represents an innovative field aimed at obtaining robust evidence from observation data using genetics towards distinguishing causation from correlation. Cardiometabolic disease is a major driver of the global disease burden. The focus of the themed issue is the application of MR in cardiometabolic disease and articles may span MR studies of cardiometabolic phenotypes, methodological papers and reviews.
In this issue, we invite articles that highlight how developments in the field have allowed for genetic association data to be leveraged for identifying causal mechanisms in cardiometabolic disease subtypes, including mediating pathways. We welcome articles that showcase insights on drug target development, including the investigation of efficacy in population subgroups, repurposing potential and adverse effects.
Prof. Dr. Andrzej Ciechanowicz
Prof. Dr. Sandosh Padmanabhan
Prof. Dr. Marek Sanak
Dr. Dipender Gill
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Mendelian randomization
- cardiovascular disease
- cardiometabolic disease
- liver disease