Special Issue "The Relationship between Psychiatric Disorders and Genetics"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Sarah Tosato
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Guest Editor
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
Interests: genetics; endophenotype; gene-environment interaction; poligenic risk score; genetic variants

Special Issue Information

Dear Colleagues,

It has been well-established that most psychiatric disorders are multifactorial and highly heritable disorders, following complex inheritance, due to the existence of genetic variants in multiple genes that can predispose to the disorders, albeit with a reduced penetrance. Thanks to the technological advancement of the last few decades as genome-wide association studies (GWASs), it has been found that most of the variation in risk among individuals is genetic, involving alleles that cover the full range of frequencies, including common alleles, rare copy number (CNV) variants and rare coding (RCV) variants. Despite this, the biological consequences of these genetic variants are largely unknown, as well as the biological basis of the clinical heterogeneity that characterizes most psychiatric disorders. Finally, with the advent of the GWAS approach, it was possible to calculate an individual score, known as the polygenic risk score, summarizing the level of genetic risk for several psychiatric disorders and to relate it to the clinical characteristics of the disease.

This Special Issue in Genes on “The Relationship between Psychiatric Disorders and Genetics” will address how genetic variants interact with environmental risk factors in determining disease susceptibility or are able to modulate the phenotypic expression of the disease. Moreover, this Special Issue will provide an overview of recent developments in specialized research topics and critical perspectives on upcoming challenges.

I’m looking forward to receiving your contribution.

Prof. Dr. Sarah Tosato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DNA variants
  • GxE interaction
  • PRS
  • Phenotypic expression

Published Papers (1 paper)

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Research

Article
Brain Anatomical Mediators of GRIN2B Gene Association with Attention/Hyperactivity Problems: An Integrated Genetic-Neuroimaging Study
Genes 2021, 12(8), 1193; https://0-doi-org.brum.beds.ac.uk/10.3390/genes12081193 - 30 Jul 2021
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Abstract
This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic GRIN2B gene variants and inattention/hyperactivity with neuroanatomical measures as intermediates. Fifty-eight children and adolescents [...] Read more.
This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic GRIN2B gene variants and inattention/hyperactivity with neuroanatomical measures as intermediates. Fifty-eight children and adolescents were evaluated for behavioral problems at three time points over approximately 7 years. The final assessment included blood drawing for genetic analyses and 3T magnetic resonance imaging. Attention/hyperactivity problems based on the Child Behavior Checklist/6-18, six GRIN2B polymorphisms and regional cortical thickness, and surface area and volume were estimated. Using general linear model (GLM) and mediation analyses, we tested whether GRIN2B exerted an influence on stable inattention/hyperactivity over development, and to what extent this effect was mediated by brain morphology. GLM results enlightened the relation between GRIN2B rs5796555-/A, volume in the left cingulate isthmus and inferior parietal cortices and inattention/hyperactivity. The mediation results showed that rs5796555-/A effect on inattention/hyperactivity was partially mediated by volume in the left isthmus of the cingulate cortex, suggesting a key role of this region in translating glutamatergic GRIN2B variations to attention/hyperactivity problems. This evidence can have important implications in the management of neurodevelopmental and psychiatric disorders. Full article
(This article belongs to the Special Issue The Relationship between Psychiatric Disorders and Genetics)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Planned Paper 1:

Brain anatomical mediators of GRIN2B gene association with attention/hyperactivity problems: an integrated genetic-neuroimaging study

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